Gene Details:

• Gene ID: Lsa006519
• Gene Family: BES1 Family
• Description: BES1 Family protein
• Species: Lactuca sativa
• Source: BES1 family gene from PlantTFDB

Protein Features:

• Pfam:  PF05687
• InterPro:  IPR008540

Annotation Proteins:

• Refseq:  XP_023760016.1  — protein BRASSINAZOLE-RESISTANT 1-like
• Swissprot:  Q8S307  — BZR1_ARATH; Protein BRASSINAZOLE-RESISTANT 1
• TrEMBL:  A0A2J6LM46  — A0A2J6LM46_LACSA; Uncharacterized protein
• STRING:  XP_009587721.1  — (Nicotiana tomentosiformis)

Family Introduction:

• Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1(BRI1-EMS-SUPPRESSOR 1), accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulates gene expression is unknown. In this study, we dissect BES1 subdomains and establish that BES1 is a transcription factor that binds to and activates BR target gene promoters both in vitro and in vivo.
• BES1 interacts with a basic helix-loop-helix protein, BIM1, to synergistically bind to E box (CANNTG) sequences present in many BR-induced promoters. Loss-of-function and gain-of-function mutants of BIM1 and its close family members display BR response phenotypes. Thus, BES1 defines a new class of plant-specific transcription factors that cooperate with transcription factors such as BIM1 to regulate BR-induced genes.

Literature:

• A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis.   DOI:  10.1016/j.cell.2004.11.044 ;  PMID:  15680330

Sequences: