Gene Details:

• Gene ID: AT1G19350.4
• Gene Name: BES1, BZR2
• Gene Family: BES1 Family
• Description: BES1 Family protein
• Species: Arabidopsis thaliana
• Source: BES1 family gene from PlantTFDB

Protein Features:

• Pfam:  PF05687
• InterPro:  IPR008540

Annotation Proteins:

• Refseq:  NP_973863.1  — Brassinosteroid signaling positive regulator (BZR1) family protein
• Swissprot:  Q9LN63  — BZR2_ARATH; Protein BRASSINAZOLE-RESISTANT 2
• TrEMBL:  F4HP45  — F4HP45_ARATH; Brassinosteroid signaling positive regulator (BZR1) family protein
• STRING:  AT1G19350.3  — (Arabidopsis thaliana)

Gene Ontology:

• GO:0009742  — Biological Process — brassinosteroid mediated signaling pathway
• GO:0042742  — Biological Process — defense response to bacterium
• GO:0045892  — Biological Process — negative regulation of transcription, DNA-templated
• GO:0005634  — Cellular Component — nucleus
• GO:0005829  — Cellular Component — cytosol
• GO:0001046  — Molecular Function — core promoter sequence-specific DNA binding
• GO:0003700  — Molecular Function — transcription factor activity, sequence-specific DNA binding
• GO:0005515  — Molecular Function — protein binding

Family Introduction:

• Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1(BRI1-EMS-SUPPRESSOR 1), accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulates gene expression is unknown. In this study, we dissect BES1 subdomains and establish that BES1 is a transcription factor that binds to and activates BR target gene promoters both in vitro and in vivo.
• BES1 interacts with a basic helix-loop-helix protein, BIM1, to synergistically bind to E box (CANNTG) sequences present in many BR-induced promoters. Loss-of-function and gain-of-function mutants of BIM1 and its close family members display BR response phenotypes. Thus, BES1 defines a new class of plant-specific transcription factors that cooperate with transcription factors such as BIM1 to regulate BR-induced genes.

Literature:

• A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis.   DOI:  10.1016/j.cell.2004.11.044 ;  PMID:  15680330

Sequences: