Gene Details:

• Gene ID: Aan007379
• Gene Family: BES1 Family
• Description: BES1 Family protein
• Species: Artemisia annua
• Source: BES1 family gene from PlantTFDB

Protein Features:

• Pfam:  PF05687
• InterPro:  IPR008540

Annotation Proteins:

• Refseq:  XP_022012104.1  — BES1/BZR1 homolog protein 4-like isoform X1
• Refseq:  XP_022012105.1  — BES1/BZR1 homolog protein 4-like isoform X2
• Swissprot:  Q9ZV88  — BEH4_ARATH; BES1/BZR1 homolog protein 4
• TrEMBL:  A0A2U1QJV0  — A0A2U1QJV0_ARTAN; BZR1-like protein
• STRING:  XP_009590977.1  — (Nicotiana tomentosiformis)

Family Introduction:

• Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1(BRI1-EMS-SUPPRESSOR 1), accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulates gene expression is unknown. In this study, we dissect BES1 subdomains and establish that BES1 is a transcription factor that binds to and activates BR target gene promoters both in vitro and in vivo.
• BES1 interacts with a basic helix-loop-helix protein, BIM1, to synergistically bind to E box (CANNTG) sequences present in many BR-induced promoters. Loss-of-function and gain-of-function mutants of BIM1 and its close family members display BR response phenotypes. Thus, BES1 defines a new class of plant-specific transcription factors that cooperate with transcription factors such as BIM1 to regulate BR-induced genes.

Literature:

• A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis.   DOI:  10.1016/j.cell.2004.11.044 ;  PMID:  15680330

Sequences: