Gene Details:

Functional Descriptions:

  • SlAP2c, an APETALA2 (AP2) family member, acts as a transcriptional repressor to regulate carotenoid biosynthesis in tomato (Solanum lycopersicum).
  • Knockout of SlAP2c in both the “MicroTom” and “Ailsa Craig” backgrounds resulted in greater lycopene accumulation, whereas overexpression of this gene led to orange-ripe fruit with significantly lower lycopene contents than the wild type.
  • We established that SlAP2c represses the expression of genes involved in lycopene biosynthesis by directly binding to the cis-elements in their promoters.
  • Overexpression of SlAP2c alters the carotenoid composition of tomato fruits.
  • SlAP2a, a homolog of SlAP2c, acts upstream of SlAP2c and alleviates the SlAP2c-induced repression of lycopene biosynthesis genes by inhibiting SlAP2c transcription during fruit ripening.
  • SlAP2c relies on its EAR motif to recruit the co-repressors TOPLESS (TPL)2/4 and forms a complex with histone deacetylase (had)1/3, thereby reducing the histone acetylation levels of lycopene biosynthesis genes.

Literature:

Gene Resources:

Orthologs:

Sequences:

cDNA Sequence
  • >Solyc02g093150.3.1
    ATATTTAAAAGTCTAGGAAACTCAAAACAAGTCCTTTTGTAGCAATAGCCAAAAAATTAAATTGTTTTCTGTTTTTATAATTTGGATTGGGTATTTTTTGTAGAGAGAAAAATGTGGGATCTAAATGAATCAGAAGAAGGTTGTTCTTCACCGATAGAGTTTGAAGGCGATGATGAGAAAGGTAAACGGGTCGGATCCGTTTCGAATTCAAGTTCATCAGCTGTAGCTGTTGATGATATATCTGAAGAGGAATTAGATGGAGAAAGAGGGAAGAAAAAGAGAGGTAAAATTTTCGGCTTCTCTATGGTGGGTCTGGGTAACGGCGATGAAGAACAGCCGGTGACCCGACAGTTTTTTCCGGTTGATGAGTCGGAAATGGGTGGTGTTGCTGCTGAAAATGGATGCCCGAATTTTCCCAGAGCTCACTGGGTTGGAGTTAAATTTTACCAAACGGAGACACTTGGCAACACGGGATTGGCCAGGCCTGTAGATATGGTTCAGCAGCAACAGCAGCCTATTAAGAAGAGCCGCCGTGGACCAAGGTCTAGAAGCTCACAGTACCGTGGGGTTACCTTCTACCGGAGAACTGGCCGGTGGGAATCTCATATATGGGATTGTGGAAAACAAGTTTATCTAGGTGGATTTGATACTGCTCATGCAGCAGCTCGGGCATACGATAGGGCAGCCATAAAATTCCGGGGAGTAGAAGCCGACATAAACTTTAGCTTAGAAGATTATGAGTCCGATTTAAAACAGATGACAAGTTTAACAAAGGAAGAATTTGTGCATGTGCTTCGAAGACAAAGTACTGGTTTTCCGAGGGGAAGCTCCAAGTATAGAGGGGTGACTTTGCACAAATGTGGTAGATGGGAAGCTAGAATGGGACAGTTCTTAGGCAAAAAGTACGTTTATTTGGGACTCTTTGATACTGAGATTGAAGCTGCCAGAGCGTATGATAAAGCTGCCATCAAGTGTAACGGGAAGGATGCAGTTACAAATTTTGATCCAAGCATTTATGAGAATGAACTAAACTCAATTGAATCTACCGATAACGTGGCTGATCATAATCTGGATTTAAGTTTGGGTGGTTCAAGCTCAAAGCAAGGAAGTCAAGAATTGGGGGATAATAGAGGTCAAAATTCTTCATCAATAATGCAATTGGATATTGATTGGCAGCGCCATGGTTTAAGGCCTGAGAAGCAATCTGCCTTAATTGATGCTCGAAGAAGAGAAAACAGGTACAATGAAACAGAAACGTTGCAACTTTTAAGCCAGACGCACTTGCATTCTCCAGCCTCCTTGAAGCATAACAATAATAATAATAGTCAAGTGCAACGGTTTGGCCAATTTATGAGACCTGGTGATCAATCCCATATGATTCAAATGTTTCCACAGCAATTTGGCTCATCAAATTATCAAATTCAATTTCCAAGTGGCAGCAATGGTGGAAGAATTGGAGCTACAAATGTAAGAGATCTATCGCTTGCGGCGACGAGTAATGGTTCTTCACAATGGCAATCCAATTTTCCTCCTCAGATATTTGTAGCTGCTGCAGCATCATCAGGATTCCCTCAGCAGATAGTAAGACCTCAGAATTGGTCCTCAGAAAATGGTTTCCATCATTCACTCATGAGACCTTCTTGACTCATTTAATAACTTGCCATATTTCTATTTGTGTTTTTTTTAAGATAATGTGTAGATTAAAGGGTTGATATTCTTAATACTCCATATATATTACCTAAGGCTCTTGGTTTGAAATTAGAAAAGAAAAAAAAAAGGTAGACAAAATGTTTTGGAAAATATGTCTCCTCGTTAATTTGTCCAATACTAACTGATCGGCAAGCTTTTCAACTAGACTTGTATTAGTTTATTCTGACTATGAACTGCCAATTTGGCCCATTCTCTCTCATTGTAACTTGTATACATTTGGGCTCTAGCTTCTCATGTAGTATTTGAAATACTATAATTTATTATTCCTTTGTTTTTGTTTTTCTTGTAACAAAAGTCCAACTACTATGTCTACTAATATATGAAAAATTTTAACTTTT
CDS Sequence
  • >Solyc02g093150.3.1
    ATGTGGGATCTAAATGAATCAGAAGAAGGTTGTTCTTCACCGATAGAGTTTGAAGGCGATGATGAGAAAGGTAAACGGGTCGGATCCGTTTCGAATTCAAGTTCATCAGCTGTAGCTGTTGATGATATATCTGAAGAGGAATTAGATGGAGAAAGAGGGAAGAAAAAGAGAGGTAAAATTTTCGGCTTCTCTATGGTGGGTCTGGGTAACGGCGATGAAGAACAGCCGGTGACCCGACAGTTTTTTCCGGTTGATGAGTCGGAAATGGGTGGTGTTGCTGCTGAAAATGGATGCCCGAATTTTCCCAGAGCTCACTGGGTTGGAGTTAAATTTTACCAAACGGAGACACTTGGCAACACGGGATTGGCCAGGCCTGTAGATATGGTTCAGCAGCAACAGCAGCCTATTAAGAAGAGCCGCCGTGGACCAAGGTCTAGAAGCTCACAGTACCGTGGGGTTACCTTCTACCGGAGAACTGGCCGGTGGGAATCTCATATATGGGATTGTGGAAAACAAGTTTATCTAGGTGGATTTGATACTGCTCATGCAGCAGCTCGGGCATACGATAGGGCAGCCATAAAATTCCGGGGAGTAGAAGCCGACATAAACTTTAGCTTAGAAGATTATGAGTCCGATTTAAAACAGATGACAAGTTTAACAAAGGAAGAATTTGTGCATGTGCTTCGAAGACAAAGTACTGGTTTTCCGAGGGGAAGCTCCAAGTATAGAGGGGTGACTTTGCACAAATGTGGTAGATGGGAAGCTAGAATGGGACAGTTCTTAGGCAAAAAGTACGTTTATTTGGGACTCTTTGATACTGAGATTGAAGCTGCCAGAGCGTATGATAAAGCTGCCATCAAGTGTAACGGGAAGGATGCAGTTACAAATTTTGATCCAAGCATTTATGAGAATGAACTAAACTCAATTGAATCTACCGATAACGTGGCTGATCATAATCTGGATTTAAGTTTGGGTGGTTCAAGCTCAAAGCAAGGAAGTCAAGAATTGGGGGATAATAGAGGTCAAAATTCTTCATCAATAATGCAATTGGATATTGATTGGCAGCGCCATGGTTTAAGGCCTGAGAAGCAATCTGCCTTAATTGATGCTCGAAGAAGAGAAAACAGGTACAATGAAACAGAAACGTTGCAACTTTTAAGCCAGACGCACTTGCATTCTCCAGCCTCCTTGAAGCATAACAATAATAATAATAGTCAAGTGCAACGGTTTGGCCAATTTATGAGACCTGGTGATCAATCCCATATGATTCAAATGTTTCCACAGCAATTTGGCTCATCAAATTATCAAATTCAATTTCCAAGTGGCAGCAATGGTGGAAGAATTGGAGCTACAAATGTAAGAGATCTATCGCTTGCGGCGACGAGTAATGGTTCTTCACAATGGCAATCCAATTTTCCTCCTCAGATATTTGTAGCTGCTGCAGCATCATCAGGATTCCCTCAGCAGATAGTAAGACCTCAGAATTGGTCCTCAGAAAATGGTTTCCATCATTCACTCATGAGACCTTCTTGA
Protein Sequence
  • >Solyc02g093150.3.1
    MWDLNESEEGCSSPIEFEGDDEKGKRVGSVSNSSSSAVAVDDISEEELDGERGKKKRGKIFGFSMVGLGNGDEEQPVTRQFFPVDESEMGGVAAENGCPNFPRAHWVGVKFYQTETLGNTGLARPVDMVQQQQQPIKKSRRGPRSRSSQYRGVTFYRRTGRWESHIWDCGKQVYLGGFDTAHAAARAYDRAAIKFRGVEADINFSLEDYESDLKQMTSLTKEEFVHVLRRQSTGFPRGSSKYRGVTLHKCGRWEARMGQFLGKKYVYLGLFDTEIEAARAYDKAAIKCNGKDAVTNFDPSIYENELNSIESTDNVADHNLDLSLGGSSSKQGSQELGDNRGQNSSSIMQLDIDWQRHGLRPEKQSALIDARRRENRYNETETLQLLSQTHLHSPASLKHNNNNNSQVQRFGQFMRPGDQSHMIQMFPQQFGSSNYQIQFPSGSNGGRIGATNVRDLSLAATSNGSSQWQSNFPPQIFVAAAASSGFPQQIVRPQNWSSENGFHHSLMRPS*