Information report for SlMKK4
Gene Details
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Functional Descriptions
- Tomato SlMKK2 and SlMKK4 contribute to disease resistance against Botrytis cinerea.
- qRT-PCR analyses revealed that expression of SlMKK2 and SlMKK4 was strongly induced by B. cinerea and by jasmonic acid and ethylene precursor 1-amino cyclopropane-1-carboxylic acid.
- Silencing of SlMKK2 or SlMKK4 resulted in reduced resistance to B. cinerea, increased accumulation of reactive oxygen species and attenuated expression of defense genes after infection of B. cinerea in tomato plants.
- VIGS-based knockdown of SlMKK2 and SlMKK4 expression in tomato and gain-of-function transient expression of constitutively active phosphomimicking forms SlMKK2DD and SlMKK2DD in N. benthamiana demonstrate that both SlMKK2 and SlMKK4 function as positive regulators of defense response against B. cinerea.
Functional Keywords
Literature and News
Gene Resources
- NCBI ID: 543948
- UniProt accessions: Q66MH6
- EMBL: AY691333
- EnsemblPlants: Solyc03g097920.1.1
- Gramene: Solyc03g097920.1.1
- KEGG: sly:543948
- GO: GO:0004674 , GO:0004708 , GO:0005524 , GO:0005737 , GO:0051707
- OMA: HILLEFC
- InterPro: IPR000719 , IPR001245 , IPR008271 , IPR011009 , IPR017441
- PANTHER: PTHR48013 , PTHR48013:SF9
- SUPFAM: SSF56112
- PROSITE: PS00107 , PS00108 , PS50011
- Gene3D: 1.10.510.10 , 3.30.200.20
- OrthoDB: Q66MH6
- Pfam: PF00069
- SMR: Q66MH6
- CDD: cd06623
- STRING: 4081.Q66MH6
- HOGENOM: CLU_000288_63_23_1
Sequences
cDNA Sequence
- >Solyc03g097920.1.1
ATGGCCTTAGTTCGTGATCGCCGACACCTAAATCTCCGTCTTCCCTTACCGGAACCCTCCGAACGACGTCCTCGTTTCCCCTTACCTCTCCCTCCATCTTCCGTACCCACCGTCAACTCTACCGCCAGCACCACCACTGCTACAAATACTACGACGACCACCACTGCTTCTACTACCACTATCTCCATTTCGGAACTTGAAAAGCTTAAGGTTCTCGGTCATGGAAACGGTGGAACTGTGTATAAAGTCCGTCATAAGCGGACCTCCGCGATCTACGCTCTGAAAGTTGTTCACGGTGATAGTGACCCAGAGATTCGCCGTCAGATCCTCCGGGAAATCTCAATTCTTCGCCGGACGGAATCTCCTTACGTTATCAAGTGTCATGGAGTTATTGATATGCCCGGCGGGGATATCGGTATTCTTATGGAGTATATGAACGCCGGTACATTAGAAAATCTACTTAAATCACAATTAACTTTCTCCGAACTCTGTTTAGCGAGAATCGCTAAGCAAGTGCTTGGTGGATTAGACTATTTGCATAGTCACAAAATCATTCACAGAGATCTAAAACCTTCGAACCTTTTAGTGAATCGTGAGATGGAGGTGAAAATCGCTGATTTCGGAGTGAGCAAAATCATGGGAAGGACTTTGGATCCTTGCAATTCATACGTTGGAACTTGTGCGTATATGAGCCCAGAAAGATTTGATCCAGACACTTATGGAGGTAACTACAATGGTTACGCAGCTGATATATGGAGCTTAGGTCTCACTTTAATGGAACTGTATATGGGCCACTTTCCGTTCCTGCCGCCGGGTCAGCGACCGGATTGGGCTACTCTGATGTGCGCTATATGCTTCGGTGAACCACCAAGTTTGCCGGAAAATACGTCGGAAAAATTCAATGATTTCATGAAGTGTTGCTTACAGAAAGAGTCCAGTAAGAGATGGAGCGCTCATCAACTTTTGCAACATCCGTTTATACAGAGTATCGATTTGAAATCCACCTAA
CDS Sequence
- >Solyc03g097920.1.1
ATGGCCTTAGTTCGTGATCGCCGACACCTAAATCTCCGTCTTCCCTTACCGGAACCCTCCGAACGACGTCCTCGTTTCCCCTTACCTCTCCCTCCATCTTCCGTACCCACCGTCAACTCTACCGCCAGCACCACCACTGCTACAAATACTACGACGACCACCACTGCTTCTACTACCACTATCTCCATTTCGGAACTTGAAAAGCTTAAGGTTCTCGGTCATGGAAACGGTGGAACTGTGTATAAAGTCCGTCATAAGCGGACCTCCGCGATCTACGCTCTGAAAGTTGTTCACGGTGATAGTGACCCAGAGATTCGCCGTCAGATCCTCCGGGAAATCTCAATTCTTCGCCGGACGGAATCTCCTTACGTTATCAAGTGTCATGGAGTTATTGATATGCCCGGCGGGGATATCGGTATTCTTATGGAGTATATGAACGCCGGTACATTAGAAAATCTACTTAAATCACAATTAACTTTCTCCGAACTCTGTTTAGCGAGAATCGCTAAGCAAGTGCTTGGTGGATTAGACTATTTGCATAGTCACAAAATCATTCACAGAGATCTAAAACCTTCGAACCTTTTAGTGAATCGTGAGATGGAGGTGAAAATCGCTGATTTCGGAGTGAGCAAAATCATGGGAAGGACTTTGGATCCTTGCAATTCATACGTTGGAACTTGTGCGTATATGAGCCCAGAAAGATTTGATCCAGACACTTATGGAGGTAACTACAATGGTTACGCAGCTGATATATGGAGCTTAGGTCTCACTTTAATGGAACTGTATATGGGCCACTTTCCGTTCCTGCCGCCGGGTCAGCGACCGGATTGGGCTACTCTGATGTGCGCTATATGCTTCGGTGAACCACCAAGTTTGCCGGAAAATACGTCGGAAAAATTCAATGATTTCATGAAGTGTTGCTTACAGAAAGAGTCCAGTAAGAGATGGAGCGCTCATCAACTTTTGCAACATCCGTTTATACAGAGTATCGATTTGAAATCCACCTAA
Protein Sequence
- >Solyc03g097920.1.1
MALVRDRRHLNLRLPLPEPSERRPRFPLPLPPSSVPTVNSTASTTTATNTTTTTTASTTTISISELEKLKVLGHGNGGTVYKVRHKRTSAIYALKVVHGDSDPEIRRQILREISILRRTESPYVIKCHGVIDMPGGDIGILMEYMNAGTLENLLKSQLTFSELCLARIAKQVLGGLDYLHSHKIIHRDLKPSNLLVNREMEVKIADFGVSKIMGRTLDPCNSYVGTCAYMSPERFDPDTYGGNYNGYAADIWSLGLTLMELYMGHFPFLPPGQRPDWATLMCAICFGEPPSLPENTSEKFNDFMKCCLQKESSKRWSAHQLLQHPFIQSIDLKST*