Gene Details:

• Gene ID:
• Gene Symbol: SlCPTBP
• Gene Name: CPT-binding protein
• Genome: Tomato Genome version SL4.0
• Species: Solanum lycopersicum

Functional Descriptions:

• Designated as CPT-binding protein (SlCPTBP), which is a close homolog of the human Nogo-B receptor.
• Yeast two-hybrid and co-immunoprecipitation assays demonstrate that SlCPT3 and its partner protein interact in vivo and that both SlCPT3 and SlCPTBP are required to complement the growth defects and dolichol deficiency of the yeast dolichol mutant, rer2∆.
• Co-expression of SlCPT3 and SlCPTBP in yeast and in E. coli confirmed that dolichol synthase activity strictly requires both proteins.
• Organelle isolation and in vivo localization of fluorescent protein fusions showed that both SlCPT3 and SlCPTBP localize to the ER, the site of dolichol accumulation and synthesis in eukaryotes.

Function-related keywords:

• growth ,  protein

Literature:

• A two-component enzyme complex is required for dolichol biosynthesis in tomato.   DOI:  10.1111/tpj.12859 ;  PMID:  25899081

Related News:

Gene Resources:

• NCBI ID: 101250227
• UniProt accessions: A0A3Q7GXI0

Orthologs:

Sequences: