Information report for Vradi02g00170
Gene Details
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Functional Annotation
- Encodes a 645-amino acid methylcytosine-binding protein with a PHD domain, two RING finger domains, and an SRA domain that is involved in centromere heterochromatinization. This protein functions as an E3 ubiquitin ligase in vitro. The protein has been shown to bind to methylated cytosines of CG, CNG and CNN motifs via its SRA domain but has a preference for the former. It plays a role in the establishment/maintenance of chromatin structure during cell division and is localized in the nucleus. Plants over-expressing VIM1/ORTH2 show an inhibition in root growth and a delay in flowering. Both over-expression of GFP:ORTH2 and loss of ORTH2/VIM1 lead to decreased levels of DNA methylation. GFP:ORTH2 over-expressers also have increased levels of FWA transcripts.
Homologous
- Capsicum annuum: T459_27745
- Citrullus lanatus: Cla97C11G206990
- Cucumis melo: MELO3C008906
- Glycine max: Glyma.12G001300
- Gossypium hirsutum: Gohir.D11G003600, Gohir.A12G268100, Gohir.D12G268500, Gohir.A11G004100, Gohir.D09G171100, Gohir.A09G174100
- Juglans regia: Jr09_00150
- Manihot esculenta: MANES_14G168600
- Nicotiana attenuata: A4A49_12851
- Prunus avium: Pav_sc0000042.1_g620.1.mk
- Prunus persica: PRUPE_5G140900
- Rosa chinensis: RchiOBHm_Chr7g0188611, RchiOBHm_Chr7g0213481
- Solanum lycopersicum: Solyc05g023680.3
- Solanum tuberosum: PGSC0003DMG400033921
- Vitis vinifera: VIT_01s0150g00140
Gene Resources
- Pfam: PF02182 PF13445
- UniProt: A0A1S3VPI5
- RefSeq: XP_014519979.1
- AlphaFoldDB: A0A1S3VPI5
- KEGG: vra:106776997
- InterPro: IPR001841 , IPR003105 , IPR003613 , IPR011011 , IPR013083 , IPR015947 , IPR017907 , IPR018957 , IPR019786 , IPR027370 , IPR036987 , IPR045134
- PANTHER: PTHR14140 , PTHR14140:SF46
- SUPFAM: SSF57850 , SSF57903 , SSF88697
- PROSITE: PS00518 , PS01359 , PS50089 , PS51015
- Gene3D: 2.30.280.10 , 3.30.40.10
- OrthoDB: A0A1S3VPI5
- STRING: 3916.A0A1S3VPI5
Sequences
CDS Sequence
- >Vradi02g00170
ATGCTCTCTCGATCTATCAAATGCTCCATCTGCCTCAATTTACCGGAGAGGCCCGTCACGACTCCTTGTGGGCACAGTTTCTGTCTGAAATGTTTCCAGAAATGGCTTCGACAAGGAAACAAGAAATGTGTACAATGCCGCCAGCTTGTTCCGGCAAAGATGACAAGCCAGCCCCGGATCAATTCTGCATTGGTGTTTGCAATTCGCATGGCCAGGACCAATTCTAACCCTAATGGTCGTGGAGGAGATAGGACTGTCAACCATTTTTGGCACAATCAAGACAGACCCGATGAGCCCTTTACCACAGAACGTGCTCAGAGGAATGGCCGTGCCAATGCGGCCAGTGGAAAAATATTTGTGACCGTTCCTACTGATCATTTTGGCCCAATCACTGCAGAACAGGACCCCATGAGGAATCAGGGTCTGCTGGTGGGTGAGAGTTGGAGAGACAGACTGGAATGCAGACAATGGGGTGCTCACTTCGTCCCTGTGGGTGGTATTGCTGGTCAGTCAGATCGAGGTGCACAATCCGTTGTCCTTTCTGGTGGTTATGTGGATGACGAAGACCATGGAGAGTGGTTTCTCTACACTGGAAGCGGCGGTAAGGATCTTAGCGGCAACAAACGCACCAACAAGAGTCACTCTTTTGACCAGCAGTTTGAGAAGTACAACCTTGCACTTCAAGTTAGCTGTCTTAAGGGTTATCCGGTTCGAGTTGTCAGATCTCACAAAGAAAAGCGATCTTCATATGCCCCCGAGACTGGCGTGCGCTACGATGGAATTTATAGAATTGAAAAGTGTTGGCAGATAGCTGGATTGCAGGGTTTCAAAGTTTGCCGGTATCTATTCGTTAGGTGTGACAATGAACCAGCCCCCTGGACAAGTGATGATCGTGGAGATAGGCCCAGACCCTTACCGGTCATTCGTGAACTGAAAAAGGCCACCGTCACATTTGAAAGGACTGAATCTCCGTCTTGGGATTTTGATGAAGAAGATTCTCTTTGGAAGTGGAAGAAACCACCACCTCCCAGCAAACGAAAGGTGCAAAGTGAGGAACACGTAGAGGGACTAAGGGCAAGGTCAACTAGGGAAACGACGAAGTTCCAACTTGAGATGCTCAAGAAAAGATTGCACATGGGGTTCTCGTGCATGATATGCACGGAGGTTATGGTTTCACCGGTGACAACACCGTGTGCTCATAACTTCTGCAAGTCCTGTTTGGAAGGTAAATTTGCTGGTCAGGCTTTGGTGAAGGAGAGAAGCAGGGGCGGGAGAACGCTTCGGTCCCAAAAAATTGTGATACAATGTCCTTCTTGCCCTATTGACATTTCTGACTATCTTCAGCACATTCAGGTTAATGTAGATTTGAAGGATGCGATTGAGTCACTGAAAGCCAATGTTGCAGAAATTGAAAAATCGCTGGAGTCAATTGGAGATGAAGCAGATGGATTAGATGACAATACTGATTCAGGGAACCAAAATTCTGCTAAGGAGTTGAACGATCTACCTGAAGGATCTGATGTTGATGAGCTTGAGGACACCGGTAATGAGGAGCAAGATCCAGAAGTAATGTGCAATAGAAAGAGAAAGAAAGGTGATGATGAAACACAATCGCCTGATGATAAAATGGATAAAAGAGATAAAATAAACAAAATGACTGAGCAAGAAGTGGATGATAAAAATGATTCTTCATCATCATGTCCTCTCAATCTTCCATGA
Protein Sequence
- >Vradi02g00170
MLSRSIKCSICLNLPERPVTTPCGHSFCLKCFQKWLRQGNKKCVQCRQLVPAKMTSQPRINSALVFAIRMARTNSNPNGRGGDRTVNHFWHNQDRPDEPFTTERAQRNGRANAASGKIFVTVPTDHFGPITAEQDPMRNQGLLVGESWRDRLECRQWGAHFVPVGGIAGQSDRGAQSVVLSGGYVDDEDHGEWFLYTGSGGKDLSGNKRTNKSHSFDQQFEKYNLALQVSCLKGYPVRVVRSHKEKRSSYAPETGVRYDGIYRIEKCWQIAGLQGFKVCRYLFVRCDNEPAPWTSDDRGDRPRPLPVIRELKKATVTFERTESPSWDFDEEDSLWKWKKPPPPSKRKVQSEEHVEGLRARSTRETTKFQLEMLKKRLHMGFSCMICTEVMVSPVTTPCAHNFCKSCLEGKFAGQALVKERSRGGRTLRSQKIVIQCPSCPIDISDYLQHIQVNVDLKDAIESLKANVAEIEKSLESIGDEADGLDDNTDSGNQNSAKELNDLPEGSDVDELEDTGNEEQDPEVMCNRKRKKGDDETQSPDDKMDKRDKINKMTEQEVDDKNDSSSSCPLNLP