Information report for A4A49_27251
Gene Details
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Functional Annotation
- Encodes calcium dependent protein kinase 6 (CPK6), a member of the Arabidopsis CDPK gene family. CDPKs contain an intrinsic Ca2+-activation domain with four EF hand Ca2+-binding sites. CDPKs protein kinases have been proposed to function in multiple plant signal transduction pathways downstream of [Ca2+]cyt elevations, thus transducing various physiological responses. CPK6 is expressed in both guard cells and mesophyll cells. Functions in guard cell ion channel regulation. ABA and Ca(2+) activation of slow-type anion channels and, interestingly, ABA activation of plasma membrane Ca(2+)-permeable channels were impaired in independent alleles of single and double cpk3cpk6 mutant guard cells. Furthermore, ABA- and Ca(2+)-induced stomatal closing were partially impaired in these cpk3cpk6 mutant alleles. The protein kinase CPK6 is shown in biochemical assays to be directly activated by elevations in calcium concentrations in the physiological range (Laanements et al., 2013 PlantPhys.; PMID: 23766366). These data correlate with the in vivo function of CPK6 in Ca2+ and ABA activation of S-type anion channels (Mori et al., 2006 PLoS Biol.; PMID: 17032064) and the ability of CPK6 to mediate ABA activation of SLAC1 (Brandt et al., 2012 PNAS; PMID: 22689970).
Homologous
- Arabidopsis thaliana — AT2G17290
Gene Resources
- Pfam: PF13499 PF00069
- UniProt: A0A1J6KZP2
- EMBL: MJEQ01002156
- AlphaFoldDB: A0A1J6KZP2
- KEGG: nau:109213018
- OMA: YTEFIIV
- InterPro: IPR000719 , IPR002048 , IPR008271 , IPR011009 , IPR011992 , IPR017441 , IPR018247 , IPR050205
- PANTHER: PTHR24349
- SUPFAM: SSF47473 , SSF56112
- PROSITE: PS00018 , PS00107 , PS00108 , PS50011 , PS50222
- Gene3D: 1.10.238.10 , 1.10.510.10 , 3.30.200.20
- OrthoDB: A0A1J6KZP2
- SMR: A0A1J6KZP2
- CDD: cd05117
- STRING: 49451.A0A1J6KZP2
Sequences
CDS Sequence
- >A4A49_27251
ATGGGCAATACATGCCGTGGATCTATCGGAGGCAAAACTTTTCAGGGCTACGCTCAGCCCGAAGATAGTTCTAACTCCAATTCCAATCGCGAACCTTCATCTGCCAATTCTTATTCTTCCTCTGACAATTTCTCACCTTCTAATCACAAAAAGGAACAAAAATCATTATCTCTCGTCAGCCCTAGAAAAGCAAGTATGAATCGTACGGGCAGTAATCAGGCTTATTACGTAATGGGGCATAAAACCCCTAATATTCGTGATTTTTACACATTGGGTCGTAAATTAGGACAAGGTCAATTTGGTACAACTTATTTATGTACGGAGAATTCTACGGGAAATGAATATGCTTGTAAATCTATTTCGAAGCGAAAATTGATTTCGAAAGAGGATGTTGAAGATGTTAGGAGAGAAATTCAAATAATGCATCATTTAGCTGGGCACAAAAATATTGTTACAATTAAAGGAGCTTATGAGGATCCTTTATATGTTCATATTGTTATGGAGCTATGTAGTGGTGGTGAATTGTTTGATCGAATTATTCAACGAGGACATTATAGTGAGAGAAAAGCAGCTGAATTGACTAGAATTGTTGTCGGGGTTGTAGAAGCGTGCCATTCGCTTGGTGTTATGCATAGAGATCTTAAACCTGAGAATTTCTTGTTGGTTAATAAGGATGATGATTTCTCTCTTAAGGCCATTGATTTTGGACTCTCTGTTTTCTTTAAACCAGGCCAAATATTTAAGGATGTTGTTGGTAGTCCATATTACGTGGCTCCTGAGGTTCTTTTGAAGCATTATGGTCCTGAAGCGGATGTGTGGACAGCAGGGGTCATACTATACATACTGCTAAGTGGTGTTCCACCATTTTGGGCTGAAACGCAGCAGGGGATATTTGACGCAGTTCTGAAAGGGCACATTGATTTTGATTCAGACCCTTGGCCGTTGATATCTGAGAGCGCAAAAGATCTTATCCGGAAGATGTTGTGCATGCAGCCGTCGGAGCGGTTAACTGCTCATGAAGTATTGTGCCATCCTTGGATTTGCGAAAATGGTGTCGCTCCTGATAGAGCACTGGATCCTGCAGTACTTTCCCGCCTTAAACAGTTCTCTGCTATGAACAAGTTAAAAAAGATGGCTTTGCGGGTGATTGCTGAAAGCTTGTCAGAAGAAGAGATTGCTGGTCTGAGAGAGATGTTTAAGGCCATGGATACAGATAATAGTGGTGCAATTACATTTGATGAACTAAAAGCTGGGTTGAGAAAATATGGCTCTACATTAAAGGATACGGAGATACGGGAACTTATGAATGCGGCTGATGTGGACAATAGTGGGACTATTGACTATGGGGAATTCATTGCGGCAACTGTTCATCTTAATAAATTGGAGCGCGAGGAACATCTCATGGCAGCATTTCAATATTTTGACAAGGATGGAAGTGGTTATATAACGGTTGATGAGGTCCAGCAAGCTTGTGTAGAGCATAACATTACAGATGTTTACTTTGAGGATATTATAAGAGAAGTCGATCAGGATAATGATGGACGAATTGATTATGGGGAATTTGTTGCTATGATGCAAAAAGGAAATCCTTGTGGTGTAGGGAGACGAACAATGCGAAATAGTCTGAATTTGAGCATGAGAGATGCAGCAGGAGCTCATTAG
Protein Sequence
- >A4A49_27251
MGNTCRGSIGGKTFQGYAQPEDSSNSNSNREPSSANSYSSSDNFSPSNHKKEQKSLSLVSPRKASMNRTGSNQAYYVMGHKTPNIRDFYTLGRKLGQGQFGTTYLCTENSTGNEYACKSISKRKLISKEDVEDVRREIQIMHHLAGHKNIVTIKGAYEDPLYVHIVMELCSGGELFDRIIQRGHYSERKAAELTRIVVGVVEACHSLGVMHRDLKPENFLLVNKDDDFSLKAIDFGLSVFFKPGQIFKDVVGSPYYVAPEVLLKHYGPEADVWTAGVILYILLSGVPPFWAETQQGIFDAVLKGHIDFDSDPWPLISESAKDLIRKMLCMQPSERLTAHEVLCHPWICENGVAPDRALDPAVLSRLKQFSAMNKLKKMALRVIAESLSEEEIAGLREMFKAMDTDNSGAITFDELKAGLRKYGSTLKDTEIRELMNAADVDNSGTIDYGEFIAATVHLNKLEREEHLMAAFQYFDKDGSGYITVDEVQQACVEHNITDVYFEDIIREVDQDNDGRIDYGEFVAMMQKGNPCGVGRRTMRNSLNLSMRDAAGAH