Gene Details:

• MSU gene ID: None
• RAPdb gene ID: None
• Gene Symbol: RGA5
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• Two NB-LRR protein-coding genes from rice (Oryza sativa), RGA4 and RGA5, were found to be required for the recognition of the Magnaporthe oryzae effector AVR1-CO39.
• The rice resistance protein pair RGA4/RGA5 recognizes the Magnaporthe oryzae effectors AVR-Pia and AVR1-CO39 by direct binding.
• The rice NLR RGA5 recognizes the Magnaporthe oryzae effector AVR-Pia through direct interaction.
• We relied for this on detailed knowledge on the recognition of the Magnaporthe oryzae effectors AVR-PikD, AVR-Pia, and AVR1-CO39 by, respectively, the rice NLRs Pikp-1 and RGA5.
• The rice nucleotide-binding (NB) and leucine-rich repeat (LRR) domain immune receptors (NLRs) RGA4 and RGA5 form a helper NLR/sensor NLR (hNLR/sNLR) pair that specifically recognizes the effectors AVR-Pia and AVR1-CO39 from the blast fungus Magnaporthe oryzae.
• By analysing structure-informed point mutations in the RGA5(HMA) -binding surface in protein interaction studies and in Nicotiana benthamiana cell death assays, we found that HMA self-interaction does not contribute to RGA5 function.

Function-related keywords:

• magnaporthe-oryzae ,  blast ,  cell-death

Literature:

• A multifaceted genomics approach allows the isolation of the rice Pia-blast resistance gene consisting of two adjacent NBS-LRR protein genes .  DOI:  10.1111/j.1365-313X.2011.04502.x ;  PMID:  21251109
• The rice resistance protein pair RGA4/RGA5 recognizes the Magnaporthe oryzae effectors AVR-Pia and AVR1-CO39 by direct binding .  DOI:  10.1105/tpc.112.107201 ;  PMID:  23548743
• Ectopic activation of the rice NLR heteropair RGA4/RGA5 confers resistance to bacterial blight and bacterial leaf streak diseases .  DOI:  10.1111/tpj.13231 ;  PMID:  27289079
• Recognition of the Magnaporthe oryzae Effector AVR-Pia by the Decoy Domain of the Rice NLR Immune Receptor RGA5 .  DOI:  10.1105/tpc.16.00435 ;  PMID:  28087830
• A designer rice NLR immune receptor confers resistance to the rice blast fungus carrying noncorresponding avirulence effectors .  DOI:  10.1073/pnas.2110751118 ;  PMID:  34702740
• New recognition specificity in a plant immune receptor by molecular engineering of its integrated domain .  DOI:  10.1038/s41467-022-29196-6 ;  PMID:  35314704
• The synthetic NLR RGA5HMA5 requires multiple interfaces within and outside the integrated domain for effector recognition .  DOI:  10.1038/s41467-024-45380-2 ;  PMID:  38321036

Related News:

Gene Resources:

• NCBI ID: AB604627  , KC777364
• UniProt accessions:

Sequences: