Gene Details:

• MSU gene ID: None
• RAPdb gene ID: Os01g0689300
• Gene Symbol: OsHRZ1
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• Here we report the identification of new iron regulators in rice, designated Oryza sativa Haemerythrin motif-containing Really Interesting New Gene (RING)- and Zinc-finger protein 1 (OsHRZ1) and OsHRZ2.
• OsHRZ1, OsHRZ2 and their Arabidopsis homologue BRUTUS bind iron and zinc, and possess ubiquitination activity.
• OsHRZ1 and OsHRZ2 are susceptible to degradation in roots irrespective of iron conditions.
• These results suggest that OsHRZ1 and OsHRZ2 are iron-binding sensors that negatively regulate iron acquisition under conditions of iron sufficiency.
• Many jasmonate-inducible genes were also negatively regulated by the ubiquitin ligases OsHRZ1 and OsHRZ2 and positively regulated by the transcription factor IDEF1.
• C1 (OE) rice plants modify the expression of the putative iron-sensing factors OsHRZ1 and OsHRZ2 and enhance the expression of OsIRO2 under copper excess, which suggests a role of copper transport in iron signaling.
• Transgenic rice plants with repressed expression of OsHRZ1 and OsHRZ2 (HRZ knockdown lines) are tolerant to low iron availability and accumulate iron in shoots and seeds under both iron-sufficient and -deficient conditions without a growth penalty.
• Two iron-binding ubiquitin ligases, OsHRZ1 and OsHRZ2, negatively regulate such iron deficiency responses in rice (Oryza sativa).

Function-related keywords:

• zinc ,  iron ,  root ,  transcription-factor ,  Ubiquitin ,  copper ,  growth

Literature:

• Iron-binding haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation .  DOI:  10.1038/ncomms3792 ;  PMID:  24253678
• Jasmonate signaling is activated in the very early stages of iron deficiency responses in rice roots .  DOI:  10.1007/s11103-016-0486-3 ;  PMID:  27143046
• Copper and ectopic expression of the Arabidopsis transport protein COPT1 alter iron homeostasis in rice (Oryza sativa L.) .  DOI:  10.1007/s11103-017-0622-8 ;  PMID:  28631167
• Rice HRZ ubiquitin ligases are crucial for response to excess iron .  DOI:  10.1111/ppl.12698 ;  PMID:  29655221
• Simultaneous Enhancement of iron Deficiency Tolerance and Iron Accumulation in Rice by Combining the Knockdown of OsHRZ Ubiquitin Ligases with the Introduction of Engineered Ferric-chelate Reductase .  DOI:  10.1186/s12284-022-00598-w ;  PMID:  36315339

Related News:

Gene Resources:

• NCBI ID:
• UniProt accessions:

Sequences: