Gene Details:

• MSU gene ID: LOC_Os12g38210
• RAPdb gene ID: Os12g0570000
• Gene Symbol: SPL11
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• Expression analysis indicated that SPL11 is induced in both incompatible and compatible rice-blast interactions.
• The rice (Oryza sativa) E3 ligase SPOTTED LEAF11 (SPL11) negatively regulates programmed cell death and disease resistance.
• The rice U-box/ARM E3 ubiquitin ligase SPL11 negatively regulates programmed cell death (PCD) and disease resistance, and controls flowering time through interacting with the novel RNA/DNA binding KH domain protein SPIN1.
• These results suggest that RBS1 is a new negative regulator of flowering time that itself is positively regulated by SPIN1 but negatively regulated by SPL11 in rice.
• SPIN1, a K homology domain protein negatively regulated and ubiquitinated by the E3 ubiquitin ligase SPL11, is involved in flowering time control in rice.
• In vitro ubiquitination assay indicated that the SPL11 protein possesses E3 ubiquitin ligase activity that is dependent on an intact U-box domain, suggesting a role of the ubiquitination system in the control of plant cell death and defense.
• We found that spl2, spl7 and SPL11 mutant cells accumulated increased amounts of H(2)O(2) in response to rice blast fungal elicitor.
• We demonstrate here that SPL11 also regulates flowering via interaction with SPIN1 (for SPL11-interacting protein1), a Signal Transduction and Activation of RNA family member.
• SPL11 mutants have delayed flowering under long-day conditions.
• Our data are consistent with a model in which SPIN1 acts as a negative regulator of flowering that itself is negatively regulated by SPL11, possibly via ubiquitination.
• The rice (Oryza sativa) spotted leaf11 (SPL11) mutant was identified from an ethyl methanesulfonate-mutagenized indica cultivar IR68 population and was previously shown to display a spontaneous cell death phenotype and enhanced resistance to rice fungal and bacterial pathogens.

Function-related keywords:

• blast ,  disease ,  disease-resistance ,  flowering-time ,  defense ,  leaf ,  flower ,  cell-death

Literature:

• RBS1, an RNA binding protein, interacts with SPIN1 and is involved in flowering time control in rice .  DOI:  10.1371/journal.pone.0087258 ;  PMID:  24498057
• Spotted leaf11, a negative regulator of plant cell death and defense, encodes a U-box/armadillo repeat protein endowed with E3 ubiquitin ligase activity .  DOI:  10.1105/tpc.104.025171 ;  PMID:  15377756
• Regulatory mechanisms of ROI generation are affected by rice spl mutations .  DOI:  10.1093/pcp/pcj074 ;  PMID:  16816407
• SPIN1, a K homology domain protein negatively regulated and ubiquitinated by the E3 ubiquitin ligase SPL11, is involved in flowering time control in rice .  DOI:  10.1105/tpc.108.058610 ;  PMID:  18586868

Related News:

Gene Resources:

• NCBI ID: AY652590
• UniProt accessions:

Sequences: