Gene Details:

Functional Descriptions:

  • Here we report that LARGE2 encodes a HECT-domain E3 ubiquitin ligase OsUPL2 and regulates panicle size and grain number in rice.
  • LARGE2 regulates panicle size and grain number by repressing meristematic activity.
  • Biochemical analyses show that LARGE2 physically associates with ABERRANT PANICLE ORGANIZATION1 (APO1) and APO2, two positive regulators of panicle size and grain number, and modulates their stabilities.
  • Genetic analyses support that LARGE2 functions with APO1 and APO2 in a common pathway to regulate panicle size and grain number.
  • The loss of function LARGE2 mutants produce large panicles with increased grain number, wide grains and leaves, and thick culms.

Literature:

Gene Resources:

  • NCBI ID:
  • UniProt accessions:

Sequences:

cDNA Sequence
  • >LOC_Os12g24080.1
    AGAAGGACAACCAGTTGAAATGGATGCTGTTTCAATTATCGCAACATTCCCTTCAGAAATTCGGGAGGAGGTGCTTTTAACATCTCCAGATACATTACTGGCTACACTTACGCCTGCACTAGTTGCTGAAGCAAACATGTTAAGGGAGAGATTTGCTCATCGGTATCACAGTGGCTCCCTTTTTGGCATGAACTCCAGGGGCAGGAGAGGTGAGTCCTCTCGACGTGGTGACATAATTGGTTCAGGTCTTGATAGAAATGCTGGTGATTCTTCTCGACAACCAACTAGCAAGCCAATTGAAACGGAAGGATCTCCTCTTGTTGACAAGGATGCTCTTAAAGCTCTTATTAGGCTACTCCGGGTTGTTCAGCCTCTATACAAAGGTCAATTGCAGAGGCTTCTCTTGAACCTTTGTGCTCATAGGGAAAGCAGAAAGTCCTTGGTTCAAATTCTAGTGGACATGCTTATGCTTGATCTGCAGGGCTCTTCTAAGAAATCAATTGATGCAACTGAGCCACCATTTAGGCTATATGGGTGCCATGCAAATATTACGTACTCACGCCCTCAATCGACAGATGGCGTGCCTCCATTAGTTTCTCGTCGTGTTCTTGAAACTTTGACATACTTGGCAAGAAATCATCCAAATGTGGCTAAACTCTTGCTATTTCTTGAGTTCCCTTGCCCCCCAACTTGCCATGCTGAAACATCTGATCAGAGGCGTGGCAAGGCTGTTCTTATGGAAGGTGACAGTGAACAGAACGCTTATGCACTTGTCCTACTTTTAACCTTGTTGAATCAGCCACTTTATATGAGGAGCGTAGCTCATCTTGAACAGCTACTAAACCTTCTCGAAGTTGTTATGCTCAATGCCGAGAATGAAATTACACAAGCTAAGCTGGAAGCAGCATCTGAAAAACCATCTGGACCTGAGAATGCAACGCAAGATGCCCAAGAGGGTGCGAATGCTGCTGGATCATCTGGATCGAAGTCCAATGCTGAGGATAGCAGCAAACTCCCTCCTGTTGATGGTGAAAGTAGCCTGCAAAAAGTTCTGCAGAGTCTTCCCCAAGCAGAGCTTCGACTGCTATGTTCACTGCTTGCACATGATGGGTTGTCAGACAATGCGTATCTCCTGGTAGCAGAAGTTCTGAAAAAGATTGTAGCTCTTGCTCCTTTTTTCTGTTGCCATTTCATAAATGAACTTGCACATTCAATGCAAAATTTGACGCTTTGTGCAATGAAGGAGCTTCACTTGTATGAGGATTCTGAAAAGGCTCTTCTTAGCACATCATCAGCCAATGGCACTGCAATTCTTAGAGTTGTGCAGGCTTTGAGTTCTCTTGTCACCACTCTGCAAGAGAAAAAGGATCCAGATCATCCTGCTGAAAAAGATCATTCTGATGCATTGTCCCAGATTTCTGAAATTAACACTGCATTGGATGCATTATGGTTGGAGCTGAGTAATTGCATAAGCAAAATAGAGAGCTCTTCAGAATACGCATCGAATCTAAGTCCTGCTTCTGCAAATGCAGCCACATTAACAACAGGTGTAGCACCTCCATTGCCTGCCGGAACTCAGAACATATTACCGTACATAGAATCATTTTTCGTGACATGTGAGAAGTTACGCCCTGGGCAACCTGATGCTATTCAAGAAGCTTCAACATCTGACATGGAGGATGCATCAACTTCTAGTGGTGGGCAGAAATCATCTGGAAGCCATGCAAATCTTGATGAGAAGCACAATGCGTTTGTTAAATTCTCAGAGAAACACAGAAGATTGTTGAACGCATTTATCCGCCAAAACCCTGGGCTATTGGAGAAGTCATTCTCTCTGATGTTGAAAATCCCTCGCTTGATTGAATTTGACAACAAGCGTGCATATTTCCGGTCTAAAATTAAGCATCAGCATGATCATCATCATAGCCCTGTTAGAATTTCTGTGCGCCGGGCATATATTTTGGAGGATTCATATAACCAGCTTAGGATGCGTTCACCACAGGATTTGAAGGGTAGACTGACTGTTCATTTCCAAGGTGAAGAAGGCATTGATGCTGGTGGACTAACAAGGGAATGGTATCAGCTGCTATCACGAGTGATTTTTGATAAGGGTGCCCTTCTATTCACAACTGTTGGAAATGACTTGACATTTCAACCAAACCCTAACTCGGTGTATCAGACTGAACACCTCTCATATTTCAAATTTGTTGGGCGAGTGGTTGGTAAAGCTCTATTTGATGGCCAACTTTTGGATGTCCATTTTACAAGATCTTTCTACAAGCACATACTAGGTGTCAAGGTTACATACCATGACATTGAAGCTATTGATCCTGCATACTATAAAAATTTGAAATGGATGCTTGAGAATGACATAAGCGATGTTCTGGACCTCTCCTTCAGCATGGATGCAGATGAAGAGAAGCGGATATTGTATGAGAAGGCAGAGGTGACTGATTATGAGTTGATTCCTGGAGGCCGAAACATCAAGGTCACCGAGGAGAACAAGCATGAATATGTGAACCGGGTTGCAGAACATCGTTTAACCACTGCTATTAGGCCTCAAATCACCTCTTTTATGGAGGGATTTAATGAGCTCATTCCTGAGGAGCTGATATCAATCTTTAATGACAAAGAACTTGAACTGCTAATCAGTGGACTCCCAGACATTGACTTGGACGATCTAAAAGCAAATACAGAATATTCTGGGTACAGCATAGCTTCTCCAGTCATTCAGTGGTTCTGGGAGATTGTCCAAGGGTTCAGCAAGGAGGACAAAGCCCGGTTCCTTCAGTTTGTTACTGGCACCTCAAAGGTACCTCTGGAAGGTTTCAGTGCACTCCAAGGAATATCTGGACCACAACGATTCCAGATACACAAGGCCTACGGAAGCACCAACCATCTGCCTTCAGCACATACTTGCTTTAACCAACTAGACCTTCCTGAGTACACATCGAAAGAGCAGCTCCAGGAGAGATTGCTACTGGCTATTCATGAGGCGAATGAAGGTTTCGGATTTGGTTAATCAGTCACTCCTGCACCTGTGTGCAAGAAATTTCAGGGAGTAATGTACAGATACCGTCGGAGTTGCAATAGGCGAGGGGAATGTGCGCGGACTCTTACATAACCTGCTACTAGATTCATTTGTTGCCTGCATCAACCATCGGCGTTGGTCCCTGAAGACTGATGAGATTTGTTGACAAAGTACCGGCCTGCCCACGATGCTTTATAGGACTGGTTGCTGCGAAGGATGTGCAGGGAGGTGTAGCAGGAAGTGCTAGAAGACAGCAACTATTTGGTGTTCATAATATTTTTTTTCTTTCCCTTTTGGGTCTTTTTTGGCCATTGCCCCGTTAATAGATTTCACCTTCTCTATACATTGGACCTGTATGGAATTTTTTTCCTTTTTTATTCAAGTTTGTTTTTGGGGGGCATAGACCGGTGGAATGCAACATTAAGTAGAATGCAAGTTTTCCATCGCTATTGCATATTCAATGCACATTGACTAAAAGTGTCTGGAGCCACGGGCTGCGGCTATAAATTTTACTCCTAAGGTGATGTGTGTTCGTCGGTGA
CDS Sequence
  • >LOC_Os12g24080.1
    ATGGATGCTGTTTCAATTATCGCAACATTCCCTTCAGAAATTCGGGAGGAGGTGCTTTTAACATCTCCAGATACATTACTGGCTACACTTACGCCTGCACTAGTTGCTGAAGCAAACATGTTAAGGGAGAGATTTGCTCATCGGTATCACAGTGGCTCCCTTTTTGGCATGAACTCCAGGGGCAGGAGAGGTGAGTCCTCTCGACGTGGTGACATAATTGGTTCAGGTCTTGATAGAAATGCTGGTGATTCTTCTCGACAACCAACTAGCAAGCCAATTGAAACGGAAGGATCTCCTCTTGTTGACAAGGATGCTCTTAAAGCTCTTATTAGGCTACTCCGGGTTGTTCAGCCTCTATACAAAGGTCAATTGCAGAGGCTTCTCTTGAACCTTTGTGCTCATAGGGAAAGCAGAAAGTCCTTGGTTCAAATTCTAGTGGACATGCTTATGCTTGATCTGCAGGGCTCTTCTAAGAAATCAATTGATGCAACTGAGCCACCATTTAGGCTATATGGGTGCCATGCAAATATTACGTACTCACGCCCTCAATCGACAGATGGCGTGCCTCCATTAGTTTCTCGTCGTGTTCTTGAAACTTTGACATACTTGGCAAGAAATCATCCAAATGTGGCTAAACTCTTGCTATTTCTTGAGTTCCCTTGCCCCCCAACTTGCCATGCTGAAACATCTGATCAGAGGCGTGGCAAGGCTGTTCTTATGGAAGGTGACAGTGAACAGAACGCTTATGCACTTGTCCTACTTTTAACCTTGTTGAATCAGCCACTTTATATGAGGAGCGTAGCTCATCTTGAACAGCTACTAAACCTTCTCGAAGTTGTTATGCTCAATGCCGAGAATGAAATTACACAAGCTAAGCTGGAAGCAGCATCTGAAAAACCATCTGGACCTGAGAATGCAACGCAAGATGCCCAAGAGGGTGCGAATGCTGCTGGATCATCTGGATCGAAGTCCAATGCTGAGGATAGCAGCAAACTCCCTCCTGTTGATGGTGAAAGTAGCCTGCAAAAAGTTCTGCAGAGTCTTCCCCAAGCAGAGCTTCGACTGCTATGTTCACTGCTTGCACATGATGGGTTGTCAGACAATGCGTATCTCCTGGTAGCAGAAGTTCTGAAAAAGATTGTAGCTCTTGCTCCTTTTTTCTGTTGCCATTTCATAAATGAACTTGCACATTCAATGCAAAATTTGACGCTTTGTGCAATGAAGGAGCTTCACTTGTATGAGGATTCTGAAAAGGCTCTTCTTAGCACATCATCAGCCAATGGCACTGCAATTCTTAGAGTTGTGCAGGCTTTGAGTTCTCTTGTCACCACTCTGCAAGAGAAAAAGGATCCAGATCATCCTGCTGAAAAAGATCATTCTGATGCATTGTCCCAGATTTCTGAAATTAACACTGCATTGGATGCATTATGGTTGGAGCTGAGTAATTGCATAAGCAAAATAGAGAGCTCTTCAGAATACGCATCGAATCTAAGTCCTGCTTCTGCAAATGCAGCCACATTAACAACAGGTGTAGCACCTCCATTGCCTGCCGGAACTCAGAACATATTACCGTACATAGAATCATTTTTCGTGACATGTGAGAAGTTACGCCCTGGGCAACCTGATGCTATTCAAGAAGCTTCAACATCTGACATGGAGGATGCATCAACTTCTAGTGGTGGGCAGAAATCATCTGGAAGCCATGCAAATCTTGATGAGAAGCACAATGCGTTTGTTAAATTCTCAGAGAAACACAGAAGATTGTTGAACGCATTTATCCGCCAAAACCCTGGGCTATTGGAGAAGTCATTCTCTCTGATGTTGAAAATCCCTCGCTTGATTGAATTTGACAACAAGCGTGCATATTTCCGGTCTAAAATTAAGCATCAGCATGATCATCATCATAGCCCTGTTAGAATTTCTGTGCGCCGGGCATATATTTTGGAGGATTCATATAACCAGCTTAGGATGCGTTCACCACAGGATTTGAAGGGTAGACTGACTGTTCATTTCCAAGGTGAAGAAGGCATTGATGCTGGTGGACTAACAAGGGAATGGTATCAGCTGCTATCACGAGTGATTTTTGATAAGGGTGCCCTTCTATTCACAACTGTTGGAAATGACTTGACATTTCAACCAAACCCTAACTCGGTGTATCAGACTGAACACCTCTCATATTTCAAATTTGTTGGGCGAGTGGTTGGTAAAGCTCTATTTGATGGCCAACTTTTGGATGTCCATTTTACAAGATCTTTCTACAAGCACATACTAGGTGTCAAGGTTACATACCATGACATTGAAGCTATTGATCCTGCATACTATAAAAATTTGAAATGGATGCTTGAGAATGACATAAGCGATGTTCTGGACCTCTCCTTCAGCATGGATGCAGATGAAGAGAAGCGGATATTGTATGAGAAGGCAGAGGTGACTGATTATGAGTTGATTCCTGGAGGCCGAAACATCAAGGTCACCGAGGAGAACAAGCATGAATATGTGAACCGGGTTGCAGAACATCGTTTAACCACTGCTATTAGGCCTCAAATCACCTCTTTTATGGAGGGATTTAATGAGCTCATTCCTGAGGAGCTGATATCAATCTTTAATGACAAAGAACTTGAACTGCTAATCAGTGGACTCCCAGACATTGACTTGGACGATCTAAAAGCAAATACAGAATATTCTGGGTACAGCATAGCTTCTCCAGTCATTCAGTGGTTCTGGGAGATTGTCCAAGGGTTCAGCAAGGAGGACAAAGCCCGGTTCCTTCAGTTTGTTACTGGCACCTCAAAGGTACCTCTGGAAGGTTTCAGTGCACTCCAAGGAATATCTGGACCACAACGATTCCAGATACACAAGGCCTACGGAAGCACCAACCATCTGCCTTCAGCACATACTTGCTTTAACCAACTAGACCTTCCTGAGTACACATCGAAAGAGCAGCTCCAGGAGAGATTGCTACTGGCTATTCATGAGGCGAATGAAGGTTTCGGATTTGGTTAA
Protein Sequence
  • >LOC_Os12g24080.1
    MDAVSIIATFPSEIREEVLLTSPDTLLATLTPALVAEANMLRERFAHRYHSGSLFGMNSRGRRGESSRRGDIIGSGLDRNAGDSSRQPTSKPIETEGSPLVDKDALKALIRLLRVVQPLYKGQLQRLLLNLCAHRESRKSLVQILVDMLMLDLQGSSKKSIDATEPPFRLYGCHANITYSRPQSTDGVPPLVSRRVLETLTYLARNHPNVAKLLLFLEFPCPPTCHAETSDQRRGKAVLMEGDSEQNAYALVLLLTLLNQPLYMRSVAHLEQLLNLLEVVMLNAENEITQAKLEAASEKPSGPENATQDAQEGANAAGSSGSKSNAEDSSKLPPVDGESSLQKVLQSLPQAELRLLCSLLAHDGLSDNAYLLVAEVLKKIVALAPFFCCHFINELAHSMQNLTLCAMKELHLYEDSEKALLSTSSANGTAILRVVQALSSLVTTLQEKKDPDHPAEKDHSDALSQISEINTALDALWLELSNCISKIESSSEYASNLSPASANAATLTTGVAPPLPAGTQNILPYIESFFVTCEKLRPGQPDAIQEASTSDMEDASTSSGGQKSSGSHANLDEKHNAFVKFSEKHRRLLNAFIRQNPGLLEKSFSLMLKIPRLIEFDNKRAYFRSKIKHQHDHHHSPVRISVRRAYILEDSYNQLRMRSPQDLKGRLTVHFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGNDLTFQPNPNSVYQTEHLSYFKFVGRVVGKALFDGQLLDVHFTRSFYKHILGVKVTYHDIEAIDPAYYKNLKWMLENDISDVLDLSFSMDADEEKRILYEKAEVTDYELIPGGRNIKVTEENKHEYVNRVAEHRLTTAIRPQITSFMEGFNELIPEELISIFNDKELELLISGLPDIDLDDLKANTEYSGYSIASPVIQWFWEIVQGFSKEDKARFLQFVTGTSKVPLEGFSALQGISGPQRFQIHKAYGSTNHLPSAHTCFNQLDLPEYTSKEQLQERLLLAIHEANEGFGFG*