Gene Details:

• MSU gene ID: LOC_Os12g18360
• RAPdb gene ID: Os12g0281300
• Gene Symbol: Pita Pi-4a
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• Rice blast disease resistance to the fungal pathogen Magnaporthe grisea is triggered by a physical interaction between the protein products of the host R (resistance) gene, Pi-ta, and the pathogen Avr (avirulence) gene, AVR-Pita.
• Resistance to the blast pathogen Magnaporthe oryzae is proposed to be initiated by physical binding of a putative cytoplasmic receptor encoded by a nucleotide binding site-type resistance gene, Pi-ta, to the processed elicitor encoded by the corresponding avirulence gene AVR-Pita.
• Rice expressing the Pi-ta gene is resistant to strains of the rice blast fungus, Magnaporthe grisea, expressing AVR-Pita in a gene-for-gene relationship.
• The rice blast resistance (R) gene Pi-ta mediates gene-for-gene resistance against strains of the fungus Magnaporthe grisea that express avirulent alleles of AVR-Pita.
• Three major genes (Pi1, Piz-5 and Pita) for blast resistance on chromosomes 11, 6 and 12, respectively, were fine-mapped and closely linked RFLP markers identified.
• The Pi-ta gene in rice prevents the infections by races of Magnaporthe oryzae containing AVR-Pita.
• Molecular cloning of the AVR-Pita and Pi-ta genes will aid in deployment of R genes for effective genetic control of rice blast disease.
• In the present study, 1790 accessions were characterized for Pi-ta, and Pi-ta independent resistance genes using marker analysis, disease evaluation with the race IB-49 carrying AVR-Pita, and IE-1k not carrying AVR-Pita and sequence analysis.
• These data suggest that the AVR-Pita(176) protein binds directly to the Pi-ta LRD region inside the plant cell to initiate a Pi-ta-mediated defense response.

Function-related keywords:

• blast-disease ,  blast ,  blast-resistance ,  magnaporthe-oryzae ,  disease ,  resistant ,  defense-response ,  defense ,  disease-resistance

Literature:

• Fine mapping and DNA marker-assisted pyramiding of the three major genes for blast resistance in rice .  DOI:  10.1007/s001220051395
• Molecular diversity in rice blast resistance gene Pi-ta makes it highly effective against dynamic population of Magnaporthe oryzae .  DOI:  10.1007/s10142-013-0325-4 ;  PMID:  23818197
• Direct interaction of resistance gene and avirulence gene products confers rice blast resistance .  DOI:  10.1093/emboj/19.15.4004 ;  PMID:  10921881
• Molecular evolution of the Pi-ta gene resistant to rice blast in wild rice (Oryza rufipogon) .  DOI:  10.1534/genetics.108.089805 ;  PMID:  18622033
• Development of Dominant Rice Blast Resistance Gene Markers .  DOI:  10.2135/cropsci2002.2145
• Characterization of Pi‐ta blast resistance gene in an international rice core collection .  DOI:  10.1111/j.1439-0523.2009.01706.x
• Molecular evolution of the rice blast resistance gene Pi-ta in invasive weedy rice in the USA .  DOI:  10.1371/journal.pone.0026260 ;  PMID:  22043312
• Identification of a new locus, Ptr(t), required for rice blast resistance gene Pi-ta-mediated resistance .  DOI:  10.1094/MPMI-21-4-0396 ;  PMID:  18321185
• tA single amino acid difference distinguishes resistant and susceptible alleles of the rice blast resistance gene Pi-ta .  DOI:  10.1105/tpc.12.11.2033 ;  PMID:  11090207
• Statistical inference of selection and divergence of the rice blast resistance gene Pi-ta .  DOI:  10.1534/g3.114.014969 ;  PMID:  25335927

Related News:

Gene Resources:

• NCBI ID: AF207842  , AY196754
• UniProt accessions:

Sequences: