Information report for ART1
Gene Details
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Functional Descriptions
- A zinc finger transcription factor ART1 regulates multiple genes implicated in aluminum tolerance in rice.
- ART1 is constitutively expressed in the root, and the expression level is not affected by Al treatment.
- ART1 is localized in the nucleus of all root cells.
- Furthermore, the OsFRDL4 expression was regulated by ART1, a C2H2-type zinc finger transcription factor for Al tolerance.
- Identification of a cis-acting element of ART1, a C2H2-type zinc-finger transcription factor for aluminum tolerance in rice.
- Recent identification of a transcription factor AL RESISTANCE TRANSCRIPTION FACTOR1 (ART1) revealed that this high Al tolerance in rice is achieved by multiple genes involved in detoxification of Al at different cellular levels.
- We used the promoter region of SENSITIVE TO AL RHIZOTOXICITY1, an Al tolerance gene in the downstream of ART1.
- ART1 is a C2H2-type zinc-finger transcription factor and regulates the expression of 31 genes in the downstream.
- Expression of Nrat1 is up-regulated by Al in the roots and regulated by a C2H2 zinc finger transcription factor (ART1).
- Here, we report a C2H2-type zinc finger transcription factor ART1 (for Al resistance transcription factor 1), which specifically regulates the expression of genes related to Al tolerance in rice (Oryza sativa).
- A yeast one-hybrid assay showed that ART1 has a transcriptional activation potential and interacts with the promoter region of STAR1, an important factor in rice Al tolerance.
- Microarray analysis revealed 31 downstream transcripts regulated by ART1, including STAR1 and 2 and a couple of homologs of Al tolerance genes in other plants.
- ART1 and putrescine contribute to rice aluminum resistance via OsMYB30 in cell wall modification.
- Furthermore, transient dual-luciferase assay showed that ART1 directly inhibited the expression of OsMYB30, and in turn repressed Os4CL5-dependent 4-coumaric acid accumulation, hence reducing the Al-binding capacity of cell wall and enhancing Al resistance.
- We concluded that ART1 confers Put-promoted Al resistance via repression of OsMYB30-regulated modification of cell wall properties in rice.
Functional Keywords
Literature and News
- Identification of a cis-acting element of ART1, a C2H2-type zinc-finger transcription factor for aluminum tolerance in rice . DOI: 10.1104/pp.111.175802 ; PMID: 21502187
- An Al-inducible MATE gene is involved in external detoxification of Al in rice . DOI: 10.1111/j.1365-313X.2011.04757.x ; PMID: 21880027
- A zinc finger transcription factor ART1 regulates multiple genes implicated in aluminum tolerance in rice . DOI: 10.1105/tpc.109.070771 ; PMID: 19880795
- Plasma membrane-localized transporter for aluminum in rice . DOI: 10.1073/pnas.1004949107 ; PMID: 20937890
- ART1 and putrescine contribute to rice aluminum resistance via OsMYB30 in cell wall modification . DOI: 10.1111/jipb.13429 ; PMID: 36515424
Gene Resources
- UniProt: A0A3G1KL25
- EMBL: MF093142
- AlphaFoldDB: A0A3G1KL25
- EnsemblPlants: Os12t0170400-01
- Gramene: Os12t0170400-01
- KEGG: dosa:Os12g0170400
- InterPro: IPR013087, IPR036236, IPR044300
- PANTHER: PTHR46352, PTHR46352:SF2
- SUPFAM: SSF57667
- PROSITE: PS00028, PS50157
- Gene3D: 3.30.160.60
- OrthoDB: A0A3G1KL25
Homologs
- Panicum virgatum: Pavir.9KG060600.1.p, Pavir.3NG030500.1.p
- Setaria italica: Seita.7G287100.1.p
- Setaria viridis: Sevir.7G299300.1.p
- Zea mays: GRMZM2G068710_P08, GRMZM2G068710_P07
Sequences
cDNA Sequence
- >LOC_Os12g07280.1
GCGTTACTGCCAACCAAAGAGACGGCAAGCAAATCAGGCTGCGACACCCACAATCAGAGAGGTCTAGCTCAAGCTCAACTGCTCGAGCAGAGTGAACCGAGACTCGAGGCGACTAATCAAACAATTTCCCTCGCTATTAGTCACTGACAGCCGACTAAACTAAGATAGGATGATGGGCAATCGACGACCGATCCGTCCCCCTCCTCTCTCGATCCTGATCTTGGAATCGGGAGCCCATCCCACCCCCAAATTAATTTGACCTACAGCTCACGCCTTAGCTAGCTCCCCCAGCTTCCCGGATGCTTCCTTCGATCTCCTCTAGCTTTCTCGCTCGCCTCTCCTCTCCTGTTCTGCTGTTCTTGGTGTGGAGACACGGCTAGGCGTCCATGGCGACGAGCTGGGAGTGATTCCCCCTGCTTGATTTGATTGGATTTCAGAGGCGCCATCTCTTTTCCTAATAAAGATCACGCGAGATTATTCAGAAGCTTGCAATGGATCGCGACCAGATGACGAACACGATGCGCGATCAGGCTGCGAACCTGACCTCCATGAATCCTCTCTTCTACCCGTTCATGGCGGATGACGCTCTCCTCGGCATGGCGCCGCCGCCGCCGCAGCAGCTGCTGCCGTCGGTTAGCATCCAGCACATGGACTGGAGCCCGGACACGATGCTGGACAACCTCACCTTCATCGAGGAGAAGATCCGGCAGGTCAAGGACGTCATCCGATCCATGGCCGGCCGCCGCGCCTCGTCGTCGTCGGCGGCGACGCCGGAGCAGCAGCTTGTCAACGCCGACCTGACATGCCTCATCGTCCAGCTCATCTCCACCGCCGGCAGCCTCCTCCCGTCGCTCAAGAACTCCTCGTTCCTCAGCCGCACCACCCCGCCGCCCGCCGCCGCGGCCGGAGCCGCACAAGCGGTCAGCCTCGCCGCCGGCGAGAGCTCCAGCTCGGCTCGTAATAACGAGACGAACAGGGAAGATGAGGAGGAGCAGATGGGTAGCCCCGACTACGACGAGCTCTTCAAGGTATGGACTAACGGCGGCGCCATGGACGAATGCGTCGGCGCTGCCGGCGACGAGCAGGATGCGAGGGAGAATCCGGCGGCGGCGGCGGAGGAGGAGAAGTACGAGGTGCTGCAGCTGGAGGAGGACGAGATCCTGGCGCCGCACACGCACTTCTGCGGCATCTGCGGCAAGGGGTTCAAGCGCGACGCGAACCTGCGGATGCACATGCGCGGGCACGGCGACGAGTACAAGAGCGCGGCGGCGCTGGCGAAGCCGCCGCCGCCGCCGGAGGGGGAGGAGCAGCCGCCGCAGCCGGAGAGGAGGTACTCGTGCCCGCACGCCGGGTGCAAGCGGAACCGGATGCACGCGAGCTTCCAGCCGCTGAAGACGATCCTGTGCGTGAAGAACCACTACAAGCGGAGCCACTGCGAGAAGCGCCATGTCTGCGGCCGCTGCGGCGCCAAGCGCTTCTCCGTCATGGCCGACCTCAAGACCCACGAGAAGCACTGCGGCCGCGACCGCTGGCTCTGCTCCTGCGGCACCAGCTTCTCCCGCAAGGACAAGCTCTTCGCCCACGTCGCCCTCTTCCAGGGCCACGCCCCCGCTCTCCCCCCTCCCCCGCCGCCGCCGACGTCGGGTCGCCGCCGCCACAAGCAGGAGGAGCCGGAGTTCACGTGGGGCGGCGGCGGCGGCAATGAGTTTCTTGACGTCAAAGGGATCGCCGGCGTCGGGTCCGGCTCCGGTGGTGGGGATGAGTTCTTCTCCGCGGGAAGCTTCGGCGCCATGGATTTCGGATTCGGGCAGTTGGATGCTTCGCTCGCGATGCTGCTGCCATCCGAGCAATTCGCGGGTGATCATCAGGAGGAGAATGGTGACAAGTGAAGGTGCACATGATGCGTAGCGAGTTGCATATGATCATATATATATATATATATATATATATATGACGTATGTATTTCATGGTGTAATAGCATTGTGTTATCTAAAGTGGAAGAAGTTGTTCTTCCCATCTTGTACCATCTTATATGCACTTCTTTATTAAGATAGTTATGCAGATGATGTTGCAAACATTTCTGCATTTGATGATTTTCTGCAAACTACGGGGAAAAATAGTATAAAAGGATTTTGGTAGAGGAATTGGGAAGGGAGAGGCATAAATTCGTACAACTCTCTCTACATGTGTGTTTGG
CDS Sequence
- >LOC_Os12g07280.1
ATGGATCGCGACCAGATGACGAACACGATGCGCGATCAGGCTGCGAACCTGACCTCCATGAATCCTCTCTTCTACCCGTTCATGGCGGATGACGCTCTCCTCGGCATGGCGCCGCCGCCGCCGCAGCAGCTGCTGCCGTCGGTTAGCATCCAGCACATGGACTGGAGCCCGGACACGATGCTGGACAACCTCACCTTCATCGAGGAGAAGATCCGGCAGGTCAAGGACGTCATCCGATCCATGGCCGGCCGCCGCGCCTCGTCGTCGTCGGCGGCGACGCCGGAGCAGCAGCTTGTCAACGCCGACCTGACATGCCTCATCGTCCAGCTCATCTCCACCGCCGGCAGCCTCCTCCCGTCGCTCAAGAACTCCTCGTTCCTCAGCCGCACCACCCCGCCGCCCGCCGCCGCGGCCGGAGCCGCACAAGCGGTCAGCCTCGCCGCCGGCGAGAGCTCCAGCTCGGCTCGTAATAACGAGACGAACAGGGAAGATGAGGAGGAGCAGATGGGTAGCCCCGACTACGACGAGCTCTTCAAGGTATGGACTAACGGCGGCGCCATGGACGAATGCGTCGGCGCTGCCGGCGACGAGCAGGATGCGAGGGAGAATCCGGCGGCGGCGGCGGAGGAGGAGAAGTACGAGGTGCTGCAGCTGGAGGAGGACGAGATCCTGGCGCCGCACACGCACTTCTGCGGCATCTGCGGCAAGGGGTTCAAGCGCGACGCGAACCTGCGGATGCACATGCGCGGGCACGGCGACGAGTACAAGAGCGCGGCGGCGCTGGCGAAGCCGCCGCCGCCGCCGGAGGGGGAGGAGCAGCCGCCGCAGCCGGAGAGGAGGTACTCGTGCCCGCACGCCGGGTGCAAGCGGAACCGGATGCACGCGAGCTTCCAGCCGCTGAAGACGATCCTGTGCGTGAAGAACCACTACAAGCGGAGCCACTGCGAGAAGCGCCATGTCTGCGGCCGCTGCGGCGCCAAGCGCTTCTCCGTCATGGCCGACCTCAAGACCCACGAGAAGCACTGCGGCCGCGACCGCTGGCTCTGCTCCTGCGGCACCAGCTTCTCCCGCAAGGACAAGCTCTTCGCCCACGTCGCCCTCTTCCAGGGCCACGCCCCCGCTCTCCCCCCTCCCCCGCCGCCGCCGACGTCGGGTCGCCGCCGCCACAAGCAGGAGGAGCCGGAGTTCACGTGGGGCGGCGGCGGCGGCAATGAGTTTCTTGACGTCAAAGGGATCGCCGGCGTCGGGTCCGGCTCCGGTGGTGGGGATGAGTTCTTCTCCGCGGGAAGCTTCGGCGCCATGGATTTCGGATTCGGGCAGTTGGATGCTTCGCTCGCGATGCTGCTGCCATCCGAGCAATTCGCGGGTGATCATCAGGAGGAGAATGGTGACAAGTGA
Protein Sequence
- >LOC_Os12g07280.1
MDRDQMTNTMRDQAANLTSMNPLFYPFMADDALLGMAPPPPQQLLPSVSIQHMDWSPDTMLDNLTFIEEKIRQVKDVIRSMAGRRASSSSAATPEQQLVNADLTCLIVQLISTAGSLLPSLKNSSFLSRTTPPPAAAAGAAQAVSLAAGESSSSARNNETNREDEEEQMGSPDYDELFKVWTNGGAMDECVGAAGDEQDARENPAAAAEEEKYEVLQLEEDEILAPHTHFCGICGKGFKRDANLRMHMRGHGDEYKSAAALAKPPPPPEGEEQPPQPERRYSCPHAGCKRNRMHASFQPLKTILCVKNHYKRSHCEKRHVCGRCGAKRFSVMADLKTHEKHCGRDRWLCSCGTSFSRKDKLFAHVALFQGHAPALPPPPPPPTSGRRRHKQEEPEFTWGGGGGNEFLDVKGIAGVGSGSGGGDEFFSAGSFGAMDFGFGQLDASLAMLLPSEQFAGDHQEENGDK*