Information report for BC12;GDD1
Gene Details
|
|
Functional Descriptions
- Therefore, BC12/GDD1, a kinesin-like protein with transcription regulation activity, mediates cell elongation by regulating the GA biosynthesis pathway in rice.
- Mutation of rice BC12/GDD1, which encodes a kinesin-like protein that binds to a GA biosynthesis gene promoter, leads to dwarfism with impaired cell elongation.
- Mitotic microtubule array comparison, flow cytometric analysis and expression assays of cyclin-dependent kinase (CDK) complexes in root-tip cells showed that cell-cycle progression is affected in BC12 mutants.
- GDD1 was cloned by a map-based approach, was expressed constitutively, and was found to encode the kinesin-like protein BRITTLE CULM12 (BC12).
- BC12 mutants display dwarfism resulting from a significant reduction in cell number and brittleness due to an alteration in cellulose microfibril orientation and wall composition.
- Here, we report the functional characterization of Brittle Culm12 (BC12), a gene encoding a kinesin-4 protein.
- BC12 is expressed mainly in tissues undergoing cell division and secondary wall thickening.
- Therefore, BC12 functions as a dual-targeting kinesin protein and is implicated in cell-cycle progression, cellulose microfibril deposition and wall composition in the monocot plant rice.
- In this study we reveal that the novel BC12328Leu allele of BC12 modulated plant leaf color in yd1 plants, which has not been previously reported in studies of BC12/GDD1/MTD1/SRG1.
- We conclude that LGW regulates grain development by directly binding to the GW7 promoter and activating its expression.
- Overexpression of LGW increased the grain length, indicating that LGW is a positive regulator for regulating grain length.
- Elevating the GW7 expression levels in LGW plants rescued the small grain size phenotype.
- Our findings revealed that LGW plays an important role in regulating grain size, and manipulation of this gene provides a new strategy for regulating grain weight in rice.
- Protein sequence alignment analysis revealed that the mutation site was located at the nuclear localization signal (NLS) of LGW/BC12, resulting in the lgw protein not being located in the nucleus.
Functional Keywords
- ga , root , culm , dwarf , cell-elongation , cell-division , cellulose , leaf , leaf-color , development , grain , grain-length , grain-size , nucleus , grain-weight
Literature and News
- Brittle Culm 12, a dual-targeting kinesin-4 protein, controls cell-cycle progression and wall properties in rice . DOI: 10.1111/j.1365-313X.2010.04238.x ; PMID: 20444225
- Mutation of rice BC12/GDD1, which encodes a kinesin-like protein that binds to a GA biosynthesis gene promoter, leads to dwarfism with impaired cell elongation . DOI: 10.1105/tpc.110.081901 ; PMID: 21325138
- Characterization of a novel allele of bc12/gdd1 indicates a differential leaf color function for BC12/GDD1 in Indica and Japonica backgrounds . DOI: 10.1016/j.plantsci.2020.110585 ; PMID: 32771145
- Low grain weight, a new allele of BRITTLE CULM12, affects grain size through regulating GW7 expression in rice . DOI: 10.3389/fpls.2022.997624 ; PMID: 36176686
Gene Resources
- UniProt: Q6YUL8
- EMBL: AK100974, AP005860, AP008215
- AlphaFoldDB: Q6YUL8
- EnsemblPlants: Os09t0114500-01
- Gramene: Os09t0114500-01
- KEGG: dosa:Os09g0114500
- Orthologous matrix: YMLEIEQ
- InterPro: IPR001752, IPR019821, IPR027417
- PANTHER: PTHR47969, PTHR47969:SF15
- SUPFAM: SSF52540
- PROSITE: PS00411, PS50067
- Gene3D: 3.40.850.10
- OrthoDB: Q6YUL8
- SWISS-MODEL: Q6YUL8
- Conserved Domain Database: cd01372
- eggNOG: KOG0244
Sequences
cDNA Sequence
- >LOC_Os09g02650.1
ACCCCACCTACACACTCTTCTTCCTCCTCTTCCTTCTTCTTCTTCCTCTTCTTCTCCTCCATTTCCATTTCTCCACCCACCACCAAACATCTCCGGATCCTTCGCTCCATCCTCCTCCTAAGAAGAGCCCAAGAAGCCAGCAAGATCCAAAGATCAAGAGCAGCATTTGTAGCTGCAACTGCTGGTGCTGGTGCTGTTGCTGTTAGATCGAGGAGGATTCAACAAGTGTGTTGGTGGTGGTGGAAGTTGTTACAGAATTGCGGGTGAGAGAAGTTTCTTCACCGCACCTCACCAAAATCTCCATCCATCCGTCTGAATCCCAACTCCACCTGCAACTGCAACTGCACGGCGAGATTGCAGTACAACCCAAGAAACCATGATGAAGTGGCAGCATCAGTAGCAGTAGCAGCAGCAGGAGGAGGAGGAGGAAGAGGGCTCCTCTTTAATCCTTGCTTCACTCATCTTCATCAGAATCCTCCTTATTGGCTCCGCCTCGCATTCTGTGCTGCATCGGCTGTTGTATGGTCGGTGGCGAAGATGACGATGGAGCACGGCGAGGATTGCTGCGTCAAGGTGGCCGTCCATGTCCGCCCGCTCATCGGCGACGAGAAGCTTCAGGGCTGTAAGGACTGCGTCTCCGTCGTCTCCGGCAAGCCGCAGGTTCAGATCGGGAGCCATTCCTTCACCTTCGACCATGTGTACGGCAGCTCCGGCACGCCGTCGGCGGCCATGTTCGAGGAGTGCGTGGCGCCGCTCGTCGACGGCCTCTTCCAGGGCTACAACGCCACCGTGCTCGCATACGGCCAGACTGGGTCAGGGAAGACCTACACCATGGGGACGGCCTGCAAGGAGGGCTCACACATTGGGATTATCCCGCGTGCCATGGCCACGCTGTTCGACAAGATCGACAAGCTCAAGAACCAAGTAGAGTTCCAGCTGCGCGTTTCGTTTATTGAGATTCTGAAAGAAGAGGTGAGGGATTTGCTTGATCCTGCTACTGCTGCTGTTGGCAAACTTGAGAATGGAAATGGACATGCAACCAAGTTGTCGGTTCCAGGTAAACCCCCTGTTCAGATCCGGGAGGCGTCGAACGGGGTCATAACGTTAGCAGGATCGACCGAAGTGCATGTCACTACCCAGAAAGAAATGACGGCATGCCTTGAGCAAGGATCTCTGAGTCGTGCAACTGGAAGTACCAACATGAACAACCAATCAAGTCGTTCCCATGCCATCTTCACAATCACATTGGAGCAGATGCGCAAAGCAGATCCCATCATGACTTTAGATGGAATGCCTATTGAAGAGATGAATGAAGACTATCTCTGTGCCAAACTCCACTTAGTAGATCTTGCTGGATCAGAACGTGCTAAAAGAACTGGTTCTGATGGCCTTCGGTTTAAGGAAGGTGTTCATATCAACAGAGGACTTCTTGCTCTTGGCAATGTCATCAGTGCTCTCGGTGATGAGAAAAAGAGGAAAGAAGGCGCTCATGTTCCTTACCGGGACAGCAAACTCACTCGCCTTCTGCAGGACTCTCTAGGTGGAAACAGCAAGACTGTAATGATAGCCTGTATTAGTCCAGCAGATATCAATGCTGAAGAAACACTGAACACTTTGAAATATGCTAACCGCGCTCGTAACATCCAGAATAAGCCAATTGTAAATAGAAATCCTGTTGCTGATGAGATGAAAAGGATGCGCCAGCAAATTGAATACTTGCAAGCAGAACTCGTTTCAGCTCGAGGAGGAGTTGTCTTAGATGATGTTCAGGGTCTCAGGGAAAGGATCTCAATGCTTGAACAGAAAAATGAAGACCTTTGCAGGGAACTGTATGACCTTCGCAACCATGGTTACACTGATCCTTGTGAACCTGAACTGCAAAAAATTGGAACTGGTTACACTAAAGGTGAAGGGCTCAAAAGAAGCTTGCAAAGTACAGAACCATTTGATGTCCCCATGACTGACTCAGTAAGAGCAGGCAGCCCTAAAGATATTGATGATGAAGTGGCCAAAGAATGGGAACACACAATGCTGCAGGATAGCATGGGCAAAGAGTTGAATGAATTAAACAGACAACTGGAGCAAAAGGAGTCTGAGATGAAAATGTATGGATCTGACACTGTTGCACTTAAACAACACTTTGGAAAGAAACTTTTGGAGCTTGAAGAAGAGAAAAGAGCTGTACAGCAAGAAAGGGACAGATTGTTAGCTGAAGTTGAAAGTCTAAATGCTGATGGACAAACACACAAGTTGCGAGATGCCCAGCTGCAAAAATTAAAAACCCTTGAAGCACAGATTCTAGACCTCAAGAAAAAGCAGGAGAACCAAGTTCAACTTCTGAAGGAAAAGCAAAAGAGTGATGAAGCTGCTAAGAAGTTGCAGGAAGAAATTCATTCTATAAAGGCACAGAAGGTTCAACTACAACATAAAATCAAACAAGAAGCGGAACAATTCCGGCAATGGAAGGCTACCCGTGAAAAGGAACTCCTGCAGTTGAGGAAAGAGGGGCGGCGAAATGAGTATGAACGCCACAAACTTCAAGCACTTAATCAGCGGCAGAAGTTGGTTTTGCAGAGGAAGACTGAAGAAGCTGCGATGGCTACCAAAAGGCTGAAAGAGTTACTAGAGGCTCGGAAATCATCAGGACGTGACAACTCAGGCATGAATGGTACTTCTCCTGGCTCTCATATGACTGAGAAATCATTGCAAAAATGGCTAGAGCAAGATTTGGAAGTCATGGTGCATGTTCATGAAGTTCGAAACGAATATGAAAAGCAAAGTCAATTGCGTGCTGCACTTGGTGAGGAGCTTGCCATTTTAAAACAAGAAGATGTCATGTCTGGTGCAGCTAGTCCGCCCAGAGGGAAGAATGGAAACTCTAGGGCAAATACTTTGTCACCAAATGCAAGACAAGCTAGGATAGCATCACTTGAAAGCATGGTGACAATATCTTCAAATACTCTCGTTGCTATGGCTTCTCAACTCTCAGAAGCTGAAGAAAGAGAGCGTGCATTCTCTGGGCGTGGTCGGTGGAATCAGTTGCGTTCAATGGCAGAGGCAAAGAGTTTACTGCAGTATATATTTAACGTTGCTGCAGATGCAAGATGCCAAGTAAGGGAGAAAGAGATGGAGATCAAGGAAATGAAGGAGCAAATGACAGAGCTTGTGACCATCCTTCGACACAGCGAATCACGTAGAAGGGAAACGGAAAAGCAGCTTAAGCAAAGAGAGCAGGCAGCTGTAACTGCCACTACATCTCCAGGAAACGGAAATGGTTCAGTGAAGCACTCTGCTGATGACTCCAACACACCATTGTCACCAGTTGCGGTGCCTGCACAGAAGCAGCTGAAGTACTCTGCTGGAATTGTAAATAGCCCCAGCAAAGGGGTTCCTGCATTCAACAAACAACATCTTAAGATGGTTCCTATGGCACAGTTGCCTGTTGGCAAGAAGGTTTCAATAGCAGGGCAATCAGGAAAACTTTGGAGATGGAAAAGAAGCCACCACCAGTGGCTACTGCAGTTCAAGTGGAAGTGGCAAAAGCCCTGGAAATTGTCCGAGATGATTCGACACAGTGACGAAACGATGACAAGGACTCGACCCAGACCCCAGCTTCTTCCTCATAGACCTCAAAGAGTGATGTGAAAAAGGCTTTTCTTTTCTTTTTTTTCTTCGTCTCCACATGGACTGACACGGTTTACACAGCTAACTACCTCCACAAGGGTAACAATGCAGCTAAAAGCTCCAGGAGATCTCCTTCGTGCTTCGATTTTACTTAGCCACGGGATCGAAAAAAAAAAAGTATATGTTCATAGGGTGACTGTCTTTGGATGTAAATTTCTTGTGCCTATATAGTGAGTGTGAATGTTAGAGATGAAAATTTAGCGAGTGAGCGAGGGAGGGAGTGGCCGTTCTTCGCGAAAGCACTGACTGAGCACAATGCTTCATGTTTCAGCACTCATCAACTGGTGAGATGTCATACTTGTTGTCCTTCTGCATATAAGGAAAAATCTGTCGAAGGATGGCGTCTTGTAAAGTCCTTTCTGGTGTGCTTTTGTGATCTTGCATGGGTATAGTTGCAAGAATGATGATGAAAGTTGAGATTTTGGGTGCTTGGGCAGTGCTTATTTTCTTGTCCTTTTTTCTTTTTTGTTGATACAACACTAAGATTACATTGGTTTGGTTTGTGTTAGGAGTCTATTGATGTACTACAGCAACTTGTGCCCCTATATTTTGGCCAATTGTGTATTCTGTGCTGTTGATGCTTTGACTAAATAGAGAGCAGTTTGTGTCGACGTCT
CDS Sequence
- >LOC_Os09g02650.1
ATGACGATGGAGCACGGCGAGGATTGCTGCGTCAAGGTGGCCGTCCATGTCCGCCCGCTCATCGGCGACGAGAAGCTTCAGGGCTGTAAGGACTGCGTCTCCGTCGTCTCCGGCAAGCCGCAGGTTCAGATCGGGAGCCATTCCTTCACCTTCGACCATGTGTACGGCAGCTCCGGCACGCCGTCGGCGGCCATGTTCGAGGAGTGCGTGGCGCCGCTCGTCGACGGCCTCTTCCAGGGCTACAACGCCACCGTGCTCGCATACGGCCAGACTGGGTCAGGGAAGACCTACACCATGGGGACGGCCTGCAAGGAGGGCTCACACATTGGGATTATCCCGCGTGCCATGGCCACGCTGTTCGACAAGATCGACAAGCTCAAGAACCAAGTAGAGTTCCAGCTGCGCGTTTCGTTTATTGAGATTCTGAAAGAAGAGGTGAGGGATTTGCTTGATCCTGCTACTGCTGCTGTTGGCAAACTTGAGAATGGAAATGGACATGCAACCAAGTTGTCGGTTCCAGGTAAACCCCCTGTTCAGATCCGGGAGGCGTCGAACGGGGTCATAACGTTAGCAGGATCGACCGAAGTGCATGTCACTACCCAGAAAGAAATGACGGCATGCCTTGAGCAAGGATCTCTGAGTCGTGCAACTGGAAGTACCAACATGAACAACCAATCAAGTCGTTCCCATGCCATCTTCACAATCACATTGGAGCAGATGCGCAAAGCAGATCCCATCATGACTTTAGATGGAATGCCTATTGAAGAGATGAATGAAGACTATCTCTGTGCCAAACTCCACTTAGTAGATCTTGCTGGATCAGAACGTGCTAAAAGAACTGGTTCTGATGGCCTTCGGTTTAAGGAAGGTGTTCATATCAACAGAGGACTTCTTGCTCTTGGCAATGTCATCAGTGCTCTCGGTGATGAGAAAAAGAGGAAAGAAGGCGCTCATGTTCCTTACCGGGACAGCAAACTCACTCGCCTTCTGCAGGACTCTCTAGGTGGAAACAGCAAGACTGTAATGATAGCCTGTATTAGTCCAGCAGATATCAATGCTGAAGAAACACTGAACACTTTGAAATATGCTAACCGCGCTCGTAACATCCAGAATAAGCCAATTGTAAATAGAAATCCTGTTGCTGATGAGATGAAAAGGATGCGCCAGCAAATTGAATACTTGCAAGCAGAACTCGTTTCAGCTCGAGGAGGAGTTGTCTTAGATGATGTTCAGGGTCTCAGGGAAAGGATCTCAATGCTTGAACAGAAAAATGAAGACCTTTGCAGGGAACTGTATGACCTTCGCAACCATGGTTACACTGATCCTTGTGAACCTGAACTGCAAAAAATTGGAACTGGTTACACTAAAGGTGAAGGGCTCAAAAGAAGCTTGCAAAGTACAGAACCATTTGATGTCCCCATGACTGACTCAGTAAGAGCAGGCAGCCCTAAAGATATTGATGATGAAGTGGCCAAAGAATGGGAACACACAATGCTGCAGGATAGCATGGGCAAAGAGTTGAATGAATTAAACAGACAACTGGAGCAAAAGGAGTCTGAGATGAAAATGTATGGATCTGACACTGTTGCACTTAAACAACACTTTGGAAAGAAACTTTTGGAGCTTGAAGAAGAGAAAAGAGCTGTACAGCAAGAAAGGGACAGATTGTTAGCTGAAGTTGAAAGTCTAAATGCTGATGGACAAACACACAAGTTGCGAGATGCCCAGCTGCAAAAATTAAAAACCCTTGAAGCACAGATTCTAGACCTCAAGAAAAAGCAGGAGAACCAAGTTCAACTTCTGAAGGAAAAGCAAAAGAGTGATGAAGCTGCTAAGAAGTTGCAGGAAGAAATTCATTCTATAAAGGCACAGAAGGTTCAACTACAACATAAAATCAAACAAGAAGCGGAACAATTCCGGCAATGGAAGGCTACCCGTGAAAAGGAACTCCTGCAGTTGAGGAAAGAGGGGCGGCGAAATGAGTATGAACGCCACAAACTTCAAGCACTTAATCAGCGGCAGAAGTTGGTTTTGCAGAGGAAGACTGAAGAAGCTGCGATGGCTACCAAAAGGCTGAAAGAGTTACTAGAGGCTCGGAAATCATCAGGACGTGACAACTCAGGCATGAATGGTACTTCTCCTGGCTCTCATATGACTGAGAAATCATTGCAAAAATGGCTAGAGCAAGATTTGGAAGTCATGGTGCATGTTCATGAAGTTCGAAACGAATATGAAAAGCAAAGTCAATTGCGTGCTGCACTTGGTGAGGAGCTTGCCATTTTAAAACAAGAAGATGTCATGTCTGGTGCAGCTAGTCCGCCCAGAGGGAAGAATGGAAACTCTAGGGCAAATACTTTGTCACCAAATGCAAGACAAGCTAGGATAGCATCACTTGAAAGCATGGTGACAATATCTTCAAATACTCTCGTTGCTATGGCTTCTCAACTCTCAGAAGCTGAAGAAAGAGAGCGTGCATTCTCTGGGCGTGGTCGGTGGAATCAGTTGCGTTCAATGGCAGAGGCAAAGAGTTTACTGCAGTATATATTTAACGTTGCTGCAGATGCAAGATGCCAAGTAAGGGAGAAAGAGATGGAGATCAAGGAAATGAAGGAGCAAATGACAGAGCTTGTGACCATCCTTCGACACAGCGAATCACGTAGAAGGGAAACGGAAAAGCAGCTTAAGCAAAGAGAGCAGGCAGCTGTAACTGCCACTACATCTCCAGGAAACGGAAATGGTTCAGTGAAGCACTCTGCTGATGACTCCAACACACCATTGTCACCAGTTGCGGTGCCTGCACAGAAGCAGCTGAAGTACTCTGCTGGAATTGTAAATAGCCCCAGCAAAGGGGTTCCTGCATTCAACAAACAACATCTTAAGATGGTTCCTATGGCACAGTTGCCTGTTGGCAAGAAGGTTTCAATAGCAGGGCAATCAGGAAAACTTTGGAGATGGAAAAGAAGCCACCACCAGTGGCTACTGCAGTTCAAGTGGAAGTGGCAAAAGCCCTGGAAATTGTCCGAGATGATTCGACACAGTGACGAAACGATGACAAGGACTCGACCCAGACCCCAGCTTCTTCCTCATAGACCTCAAAGAGTGATGTGA
Protein Sequence
- >LOC_Os09g02650.1
MTMEHGEDCCVKVAVHVRPLIGDEKLQGCKDCVSVVSGKPQVQIGSHSFTFDHVYGSSGTPSAAMFEECVAPLVDGLFQGYNATVLAYGQTGSGKTYTMGTACKEGSHIGIIPRAMATLFDKIDKLKNQVEFQLRVSFIEILKEEVRDLLDPATAAVGKLENGNGHATKLSVPGKPPVQIREASNGVITLAGSTEVHVTTQKEMTACLEQGSLSRATGSTNMNNQSSRSHAIFTITLEQMRKADPIMTLDGMPIEEMNEDYLCAKLHLVDLAGSERAKRTGSDGLRFKEGVHINRGLLALGNVISALGDEKKRKEGAHVPYRDSKLTRLLQDSLGGNSKTVMIACISPADINAEETLNTLKYANRARNIQNKPIVNRNPVADEMKRMRQQIEYLQAELVSARGGVVLDDVQGLRERISMLEQKNEDLCRELYDLRNHGYTDPCEPELQKIGTGYTKGEGLKRSLQSTEPFDVPMTDSVRAGSPKDIDDEVAKEWEHTMLQDSMGKELNELNRQLEQKESEMKMYGSDTVALKQHFGKKLLELEEEKRAVQQERDRLLAEVESLNADGQTHKLRDAQLQKLKTLEAQILDLKKKQENQVQLLKEKQKSDEAAKKLQEEIHSIKAQKVQLQHKIKQEAEQFRQWKATREKELLQLRKEGRRNEYERHKLQALNQRQKLVLQRKTEEAAMATKRLKELLEARKSSGRDNSGMNGTSPGSHMTEKSLQKWLEQDLEVMVHVHEVRNEYEKQSQLRAALGEELAILKQEDVMSGAASPPRGKNGNSRANTLSPNARQARIASLESMVTISSNTLVAMASQLSEAEERERAFSGRGRWNQLRSMAEAKSLLQYIFNVAADARCQVREKEMEIKEMKEQMTELVTILRHSESRRRETEKQLKQREQAAVTATTSPGNGNGSVKHSADDSNTPLSPVAVPAQKQLKYSAGIVNSPSKGVPAFNKQHLKMVPMAQLPVGKKVSIAGQSGKLWRWKRSHHQWLLQFKWKWQKPWKLSEMIRHSDETMTRTRPRPQLLPHRPQRVM*