Information report for TOP6A2;OsTOP6A2
Gene Details
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Functional Descriptions
- The expression of OsTOP6A2, OsTOP6A3 and OsTOP6B was differentially regulated by the plant hormones, auxin, cytokinin, and abscisic acid.
- The transcript abundance of OsTOP6A2, OsTOP6A3 and OsTOP6B was also higher in prepollinated flowers and callus.
- Similar to Osspo11-1, the pollen mother cells of OsSPO11-2 T1 progeny plants, showed an absence of bivalent formation at metaphase I, aberrant segregation of homologous chromosomes and formation of nonviable tetrads.
- Similar to Osspo11-1, biallelic mutations in OsSPO11-2 first exon led to complete panicle sterility, and consequently, none of these primary transformants produced seeds.
- Assessment of the roles of OsSPO11-2 and OsSPO11-4 in rice meiosis using CRISPR/Cas9 mutagenesis.
- Altogether, this study demonstrates that whereas OsSPO11-1 and OsSPO11-2 are the likely orthologs of Arabidopsis AtSPO11-1 and AtSPO11-2, the additional OsSPO11-4 gene has no major role in wild-type rice meiosis.
- As expected, we observed very few DMC1 foci (19 on average) in the sterile Osspso11-1 mutant but surprisingly 85 foci in the sterile OsSPO11-2 mutant, indicative of a divergent function between these two SPO11 genes in rice.
Literature and News
- The double-stranded break-forming activity of plant SPO11s and a novel rice SPO11 revealed by a Drosophila bioassay . DOI: 10.1186/1471-2199-13-1 ; PMID: 22248237
- OsSpo11-4, a rice homologue of the archaeal TopVIA protein, mediates double-strand DNA cleavage and interacts with OsTopVIB . DOI: 10.1371/journal.pone.0020327 ; PMID: 21637817
- Overexpression of putative topoisomerase 6 genes from rice confers stress tolerance in transgenic Arabidopsis plants . DOI: 10.1111/j.1742-4658.2006.05518.x ; PMID: 17116242
- Assessment of the roles of SPO11-2 and SPO11-4 in meiosis in rice using CRISPR/Cas9 mutagenesis . DOI: 10.1093/jxb/eraa391 ; PMID: 32842152
Gene Resources
- UniProt: Q6ZD95
- EMBL: AB219538, AP004460, AP008214
- AlphaFoldDB: Q6ZD95
- EnsemblPlants: Os08t0156900-01
- Gramene: Os08t0156900-01
- KEGG: dosa:Os08g0156900
- Orthologous matrix: CNVKWIG
- InterPro: IPR002815, IPR013049, IPR034136
- PANTHER: PTHR10848, PTHR10848:SF0
- SUPFAM: SSF56726
- PROSITE: PS52041
- Gene3D: 1.10.10.10, 3.40.1360.10
- OrthoDB: Q6ZD95
- SWISS-MODEL: Q6ZD95
- Conserved Domain Database: cd00223
- eggNOG: KOG2795
Sequences
cDNA Sequence
- >LOC_Os08g06050.1
AGCGGAAACCTGGGCGAGTTGTCCGTTGGCGCCGCCGCCGGCGAGCTCGCGCACGGCCGCCGCGGCAGTACGGGATGGCGGAGGCGGGAGTGGCGGCCGCCTCGCTCTTCGGCGCCGACCGCCGCCTCTGCTCCGCCGACATCCTCCCTCCCGCCGAGGTGCGGGCGAGGATCGAGGTGGCGGTGCTCAACTTCCTCGCGGCGCTCACCGACCCGGCCGCACCGGCCATCTCCGCCCTCCCGCTGATCAGCCGGGGCGCCGCCAACCGCGGCCTGCGGCGCGCGCTGCTGCGCGACGACGTCTCGTCGGTGTACCTCTCCTACGCCTCCTGCAAGAGATCCCTCACGAGGGCCAACGACGCCAAGGCATTCGTTAGAGTGTGGAAGGTGATGGAGATGTGCTACAAGATTTTGGGGGAGGGGAAGCTGGTCACCCTGAGGGAGCTGTTCTACACGCTCCTCTCTGAATCGCCCACCTACTTCACCTGCCAGCGGCATGTCAACCAGACTGTTCAAGATGTCGTCTCGTTGCTCCGGTGTACGAGGCAGAGCCTGGGGATCATGGCGTCGAGTAGAGGGGCACTGATTGGGCGGCTTGTGGTGCAGGGGCCGGAGGAAGAACATGTTGACTGCTCCATTCTTGGACCTTCTGGGCATGCGATCACTGGAGATCTCAATGTATTGAGCAAATTAATCTTTTCTTCAGATGCGCGGTATATCATTGTAGTGGAGAAGGATGCCATATTTCAGAGGCTGGCTGAAGATCGCATATATAGTCACCTTCCGTGTATCCTGATTACTGCAAAAGGATATCCTGATCTTGCCACAAGGTTTATCTTGCATCGACTGAGCCAGACTTATCCGAACATGCCGATTTTCGCATTAGTAGACTGGAACCCAGCAGGGCTTGCTATACTATGCACTTACAAGTATGGAAGCATTTCAATGGGTTTGGAATCATACAGATATGCTTGCAATGTAAAATGGCTTGGCCTAAGAGGAGATGATCTGCAGCTTATACCTCAGAGCGCATATCAAGAACTGAAGCCACGTGATCTGCAGATTGCCAAAAGCTTGCTGTCATCTAAGTTTCTGCAGGACAAGCACAGAGCTGAGCTGACACTGATGTTGGAGACAGGCAAGCGTGCCGAGATCGAAGCTCTCTACTCACATGGGTTTGATTTCCTGGGGAAATATGTTGCAAGGAAGATTGTACAGGGTGATTACATTTGACAGTGCATTGCTGCCTGCCTCATGGTTTCTCTGGTTTTACTGAGAACTGAAATTTTGAGCTGATTCCATCAGCCCTGGCCCTGTCCAGTTTTCTTCAAAAATGACTTGTATCTTTGAAGAATGTTGCTGTTGTTACTGCACGTCCCCTGCGTGAGTATGCTGTATGCAGAATACTTGAAATTATTACACCATCTGAAGGTGAAGGAGAAATCTGAACCTTGACATACACAAAAGGATACTGCTATACATCCCCAGAATGTCAGTAGTAAACTGCTCAGCTGTGGACTACTGGATGTAAATTGTAGTCTAGCAGTTGCATATATCTCCTCCTTTTTACCTCCTTTATTAAACAAAGATCAAACGGTCTTTAGTGTGTTAACACATGGAATATTGTCGGATTTACTGCAGTTCTAAGGTGCTGTTTGATTCACTTCC
CDS Sequence
- >LOC_Os08g06050.1
ATGGCGGAGGCGGGAGTGGCGGCCGCCTCGCTCTTCGGCGCCGACCGCCGCCTCTGCTCCGCCGACATCCTCCCTCCCGCCGAGGTGCGGGCGAGGATCGAGGTGGCGGTGCTCAACTTCCTCGCGGCGCTCACCGACCCGGCCGCACCGGCCATCTCCGCCCTCCCGCTGATCAGCCGGGGCGCCGCCAACCGCGGCCTGCGGCGCGCGCTGCTGCGCGACGACGTCTCGTCGGTGTACCTCTCCTACGCCTCCTGCAAGAGATCCCTCACGAGGGCCAACGACGCCAAGGCATTCGTTAGAGTGTGGAAGGTGATGGAGATGTGCTACAAGATTTTGGGGGAGGGGAAGCTGGTCACCCTGAGGGAGCTGTTCTACACGCTCCTCTCTGAATCGCCCACCTACTTCACCTGCCAGCGGCATGTCAACCAGACTGTTCAAGATGTCGTCTCGTTGCTCCGGTGTACGAGGCAGAGCCTGGGGATCATGGCGTCGAGTAGAGGGGCACTGATTGGGCGGCTTGTGGTGCAGGGGCCGGAGGAAGAACATGTTGACTGCTCCATTCTTGGACCTTCTGGGCATGCGATCACTGGAGATCTCAATGTATTGAGCAAATTAATCTTTTCTTCAGATGCGCGGTATATCATTGTAGTGGAGAAGGATGCCATATTTCAGAGGCTGGCTGAAGATCGCATATATAGTCACCTTCCGTGTATCCTGATTACTGCAAAAGGATATCCTGATCTTGCCACAAGGTTTATCTTGCATCGACTGAGCCAGACTTATCCGAACATGCCGATTTTCGCATTAGTAGACTGGAACCCAGCAGGGCTTGCTATACTATGCACTTACAAGTATGGAAGCATTTCAATGGGTTTGGAATCATACAGATATGCTTGCAATGTAAAATGGCTTGGCCTAAGAGGAGATGATCTGCAGCTTATACCTCAGAGCGCATATCAAGAACTGAAGCCACGTGATCTGCAGATTGCCAAAAGCTTGCTGTCATCTAAGTTTCTGCAGGACAAGCACAGAGCTGAGCTGACACTGATGTTGGAGACAGGCAAGCGTGCCGAGATCGAAGCTCTCTACTCACATGGGTTTGATTTCCTGGGGAAATATGTTGCAAGGAAGATTGTACAGGGTGATTACATTTGA
Protein Sequence
- >LOC_Os08g06050.1
MAEAGVAAASLFGADRRLCSADILPPAEVRARIEVAVLNFLAALTDPAAPAISALPLISRGAANRGLRRALLRDDVSSVYLSYASCKRSLTRANDAKAFVRVWKVMEMCYKILGEGKLVTLRELFYTLLSESPTYFTCQRHVNQTVQDVVSLLRCTRQSLGIMASSRGALIGRLVVQGPEEEHVDCSILGPSGHAITGDLNVLSKLIFSSDARYIIVVEKDAIFQRLAEDRIYSHLPCILITAKGYPDLATRFILHRLSQTYPNMPIFALVDWNPAGLAILCTYKYGSISMGLESYRYACNVKWLGLRGDDLQLIPQSAYQELKPRDLQIAKSLLSSKFLQDKHRAELTLMLETGKRAEIEALYSHGFDFLGKYVARKIVQGDYI*