Gene Details:
- MSU gene ID: LOC_Os07g03770
- RAPdb gene ID: Os07g0129700
- Gene Symbol: D6 OSH15 Oskn3 RLB
- Genome: MSU7 , IRGSP-1.0
- Species: Oryza sativa
Functional Descriptions:
- Whereas Oskn3 transformants showed the most pronounced phenotypic effects during vegetative development, Oskn2 transformants showed relatively mild alterations in the vegetative phase but a more severely affected flower morphology.
- Overexpression of SUI1 and SUI2 caused outgrowths of internodes during vegetative development, and we showed that expression patterns of Oryza Sativa Homeobox 15 (OSH15) and Histone4 were impaired.
- We produced transgenic rice calli, which constitutively express each of four KNOX family class 1 homeobox genes of rice, OSH1, OSH16, OSH15, and OSH71, and found that constitutive and ectopic expression of such genes inhibits normal regeneration from transformed calli, which showed continuous growth around their shoot-regenerating stages.
- Whereas the expression of OSH1 continued within the shoot apical meristem, OSH15 expression within the shoot apical meristem ceased but became observable in a ring shaped pattern at the boundaries of some embryonic organs.
- RNA in situ localization data suggest that OSH15 may play roles in the shoot organization during early embryogenesis and thereafter, OSH15 may be involved in morphogenetic events around the shoot apical meristem.
- Loss-of-function mutations in the rice homeobox gene OSH15 affect the architecture of internodes resulting in dwarf plants.
- Ectopic expression of Oskn2 or Oskn3 induced similar defects in panicle branching.
- In transgenic plants carrying the OSH15 promoter-GUS reporter construct, the reporter gene was preferentially expressed in the AZ during young spikelet development.
- The RNA in situ hybridization experiment also showed that OSH15 mRNAs were abundant in the AZ during spikelet development.
- KNOX Protein OSH15 Induces Grain Shattering by Repressing Lignin Biosynthesis Genes.
- Knockdown mutations of OSH15 showed reduced seed shattering phenotypes.
- Analyses of OSH15 SH5-D double mutants showed that SH5 could not increase the degree of seed shattering when OSH15 was absent, indicating that SH5 functions together with OSH15.
- In addition to the seed shattering phenotype, OSH15 mutants displayed dwarfism and accumulated a higher amount of lignin in internodes due to increased expression of the genes involved in lignin biosynthesis.
- We conclude that OSH15 and SH5 form a dimer that enhances seed shattering by directly inhibiting lignin biosynthesis genes.
- Here, we report the map-based cloning of RLB (RICE LATERAL BRANCH) encoding a nuclear-localized, KNOX-type homeobox protein from a rice cytokinin-deficient mutant showing more tillers, sparser panicles, defected floret morphology as well as attenuated shoot regeneration from callus.
- RLB directly binds to the promoter and represses the transcription of OsCKX4, a cytokinin oxidase gene with high abundance in panicle branch meristem.
- We proposed that RLB recruits PRC2 to the OsCKX4 promoter to epigenetically repress its transcription, which suppresses the catabolism of cytokinin, thereby promoting rice lateral branching.
Function-related keywords:
- vegetative , shoot , meristem , dwarf , panicle , shoot-apical-meristem , growth , branching , architecture , flower , spikelet , grain , development , seed , lignin , shattering , seed-shattering , lignin-biosynthesis , spikelet-development , map-based-cloning , cytokinin , callus
Literature:
- Loss-of-function mutations in the rice homeobox gene OSH15 affect the architecture of internodes resulting in dwarf plants . DOI: 10.1093/emboj/18.4.992 ; PMID: 10022841
- Overexpression of rice OSH genes induces ectopic shoots on leaf sheaths of transgenic rice plants . DOI: 10.1006/dbio.2000.9624 ; PMID: 10753522
- Disruption of KNOX gene suppression in leaf by introducing its cDNA in rice . DOI: 10.1016/j.plantsci.2007.12.007
- SUI-family genes encode phosphatidylserine synthases and regulate stem development in rice . DOI: 10.1007/s00425-012-1736-5 ; PMID: 22956125
- Isolation and characterization of a rice homebox gene, OSH15 . DOI: 10.1023/a:1006065622251 ; PMID: 9869405
- Characterization of the KNOX class homeobox genes Oskn2 and Oskn3 identified in a collection of cDNA libraries covering the early stages of rice embryogenesis . DOI: 10.1023/a:1006153506868 ; PMID: 10080693
- Developmental regulation and downstream effects of the knox class homeobox genes Oskn2 and Oskn3 from rice . DOI: 10.1023/a:1014047917226 ; PMID: 11908517
- KNOX homeobox genes are sufficient in maintaining cultured cells in an undifferentiated state in rice . DOI: 10.1002/gene.1069 ; PMID: 11536429
- Regional expression of the rice KN1-type homeobox gene family during embryo, shoot, and flower development . DOI: 10.1105/tpc.11.9.1651 ; PMID: 10488233
- Positive autoregulation of a KNOX gene is essential for shoot apical meristem maintenance in rice . DOI: 10.1105/tpc.111.090050 ; PMID: 22207572
- Functional analysis of the conserved domains of a rice KNOX homeodomain protein, OSH15 . DOI: 10.1105/tpc.010113 ; PMID: 11549765
- KNOX Protein OSH15 Induces Grain Shattering by Repressing Lignin Biosynthesis Genes . DOI: 10.1104/pp.17.00298 ; PMID: 28351912
- Characterization of dwarf and narrow leaf (dnl-4) mutant in rice . DOI: 10.1080/15592324.2020.1849490 ; PMID: 33300429
- The OsmiRNA166b-OsHox32 pair regulates mechanical strength of rice plants by modulating cell wall biosynthesis . DOI: 10.1111/pbi.13565 ; PMID: 33560572
- RLB (RICE LATERAL BRANCH) recruits PRC2-mediated H3K27 tri-methylation on OsCKX4 to regulate lateral branching . DOI: 10.1093/plphys/kiab494 ; PMID: 34730827
Related News:
Gene Resources:
Sequences:
cDNA Sequence
- >LOC_Os07g03770.1
GTAGTATACACCTCCACCTTTCCCTTCCATTAATACCTCCACCCCCCACTCCTCTCCCCCATCTCCCCTCCCTCTCGCCATTGGAGCTAGACAGCTCGAGCTCCAGGAGGAAGAAGAGAGAGAGCCTAGCTGCTAGGGTTTCCATCGGATTTGGTTTTTTATTTTCTTTTTGTTTCTTGTGTGTGTTTTGATGGATCAGAGCTTTGGGAATCTTGGAGGAGGAGGAGGAGCAGGGGGGAGCGGCAAGGCGGCGGCGTCGTCGTTCCTGCAGCTGCCGCTGTCCACGGCGGCGGCGGCCACCGCGTACTACGGCACGCCGCTCGCCTTGCACCAGGCGGCGGCCGCGGCTGGCCCGTCGCAGTACCACGGTCACGGTCACCCCCACCACGGCGGCGGCCACCACCACAGCAAGCACGGCGGCGCCGGTGGTGGGGAGATCTCGGCGGCGGAGGCCGAGTCCATCAAGGCCAAGATCATGGCGCACCCCCAGTACTCCGCCCTCCTCGCAGCCTACCTCGACTGCCAGAAAGTCGGAGCGCCGCCGGAGGTGCTGGAGAGGCTGACCGCCACGGCGGCAAAGCTGGACGCCCGCCCTCCCGGCCGCCACGACGCGCGCGACCCGGAGCTCGACCAGTTCATGGAGGCGTACTGCAACATGCTGGCCAAGTACAGGGAGGAGCTGACGCGGCCGATCGACGAGGCCATGGAGTTCCTCAAGAGGGTGGAGTCGCAGCTCGACACCATCGCCGGCGGCGCCCATGGCGGCGGCGCCGGCTCGGCGCGCCTCCTCCTCGCCGATGGTAAATCTGAATGTGTTGGTTCTTCTGAGGATGACATGGACCCAAGTGGCCGCGAAAACGAGCCGCCTGAGATCGACCCGCGCGCTGAGGATAAGGAGCTCAAGTTTCAGCTTCTGAAGAAGTACAGTGGCTACTTGAGCAGCCTAAGGCAAGAATTTTCCAAGAAAAAGAAGAAAGGAAAGCTGCCTAAGGAGGCCAGGCAGAAGCTGCTTCACTGGTGGGAGCTGCACTACAAGTGGCCTTACCCCTCAGAGACGGAGAAGATTGCGCTTGCGGAATCGACAGGACTAGATCAGAAGCAGATCAACAACTGGTTCATCAACCAGAGGAAACGGCACTGGAAGCCATCGGAGGACATGCCGTTCGTCATGATGGAAGGTTTTCACCCACAGAATGCTGCTGCATTGTACATGGATGGCCCGTTCATGGCAGATGGAATGTACCGCCTCGGTTCGTGAACCTCGATCTCGATCATCGGCGTGTTTGATGAGAGATCCAATGCCAAGATAAATTGATCATGGAATGTATTCAGCATGCGTTGCAATGCATGGACATTGTTATGGAATTTTTGGTTTATTTACCTTTCACCGTGGATTGACAAGGTCTCGATCATGTTAGTGTTGATGGCTTATAGTTCTCCAGTAATGTTGTTGTTTTTCCTTTCGATGGCTTGTAAAAGTTTAGGTGTATCGGAATTTCGATCAACTTGCTCGTACGCTGGTAATTAATTTGGTGATGGTCTATATGTTGTATGGTTGTGCGTTTCAGATTGGTGTTCAAAGTTGCCTATCTGAAACAATTATATATATTTATATTGCTTCTCATTTT
CDS Sequence
- >LOC_Os07g03770.1
ATGGATCAGAGCTTTGGGAATCTTGGAGGAGGAGGAGGAGCAGGGGGGAGCGGCAAGGCGGCGGCGTCGTCGTTCCTGCAGCTGCCGCTGTCCACGGCGGCGGCGGCCACCGCGTACTACGGCACGCCGCTCGCCTTGCACCAGGCGGCGGCCGCGGCTGGCCCGTCGCAGTACCACGGTCACGGTCACCCCCACCACGGCGGCGGCCACCACCACAGCAAGCACGGCGGCGCCGGTGGTGGGGAGATCTCGGCGGCGGAGGCCGAGTCCATCAAGGCCAAGATCATGGCGCACCCCCAGTACTCCGCCCTCCTCGCAGCCTACCTCGACTGCCAGAAAGTCGGAGCGCCGCCGGAGGTGCTGGAGAGGCTGACCGCCACGGCGGCAAAGCTGGACGCCCGCCCTCCCGGCCGCCACGACGCGCGCGACCCGGAGCTCGACCAGTTCATGGAGGCGTACTGCAACATGCTGGCCAAGTACAGGGAGGAGCTGACGCGGCCGATCGACGAGGCCATGGAGTTCCTCAAGAGGGTGGAGTCGCAGCTCGACACCATCGCCGGCGGCGCCCATGGCGGCGGCGCCGGCTCGGCGCGCCTCCTCCTCGCCGATGGTAAATCTGAATGTGTTGGTTCTTCTGAGGATGACATGGACCCAAGTGGCCGCGAAAACGAGCCGCCTGAGATCGACCCGCGCGCTGAGGATAAGGAGCTCAAGTTTCAGCTTCTGAAGAAGTACAGTGGCTACTTGAGCAGCCTAAGGCAAGAATTTTCCAAGAAAAAGAAGAAAGGAAAGCTGCCTAAGGAGGCCAGGCAGAAGCTGCTTCACTGGTGGGAGCTGCACTACAAGTGGCCTTACCCCTCAGAGACGGAGAAGATTGCGCTTGCGGAATCGACAGGACTAGATCAGAAGCAGATCAACAACTGGTTCATCAACCAGAGGAAACGGCACTGGAAGCCATCGGAGGACATGCCGTTCGTCATGATGGAAGGTTTTCACCCACAGAATGCTGCTGCATTGTACATGGATGGCCCGTTCATGGCAGATGGAATGTACCGCCTCGGTTCGTGA
Protein Sequence
- >LOC_Os07g03770.1
MDQSFGNLGGGGGAGGSGKAAASSFLQLPLSTAAAATAYYGTPLALHQAAAAAGPSQYHGHGHPHHGGGHHHSKHGGAGGGEISAAEAESIKAKIMAHPQYSALLAAYLDCQKVGAPPEVLERLTATAAKLDARPPGRHDARDPELDQFMEAYCNMLAKYREELTRPIDEAMEFLKRVESQLDTIAGGAHGGGAGSARLLLADGKSECVGSSEDDMDPSGRENEPPEIDPRAEDKELKFQLLKKYSGYLSSLRQEFSKKKKKGKLPKEARQKLLHWWELHYKWPYPSETEKIALAESTGLDQKQINNWFINQRKRHWKPSEDMPFVMMEGFHPQNAAALYMDGPFMADGMYRLGS*