Gene Details:

• MSU gene ID: LOC_Os06g44840
• RAPdb gene ID: Os06g0658900
• Gene Symbol: OsHGGT HGGT SGD1 RTD1
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• cDNAs encoding homogentisic acid geranylgeranyl transferase (HGGT), which catalyzes the committed step of tocotrienol biosynthesis, were isolated from barley, wheat and rice seeds.
• Overexpression of the barley HGGT in corn seeds resulted in an increase in tocotrienol and tocopherol content of as much as six-fold.
• Our results indicate that SGD1 is essential for plant development and cold tolerance in rice.
• A map-based cloning strategy and subsequent complementation test showed that SGD1 encodes homogentisate phytyltransferase (HPT), a key enzyme in tocopherol biosynthesis.
• The RTD1 mutant showed overall growth retardation throughout the growth period.
• The cold-related C-repeat-binding factor (CBF)/dehydration-responsive element-binding protein 1 (DREB1) genes were significantly upregulated in RTD1 under natural growth conditions.
• RTD1 encodes a homogentisate phytyltransferase catalyzing a key step in rice tocopherol biosynthesis, confers cold tolerance and regulates rice development by affecting the accumulation of DELLA protein SLENDER RICE1.
• Map-based cloning revealed that the RTD1 gene encoded a homogentisate phytyltransferase, a key enzyme catalyzing the committed step in tocopherol biosynthesis.
• Cold tolerance was found to be reduced in RTD1.
• Moreover, RTD1 exhibited a reduced response to gibberellin (GA).
• Therefore, it appears that the antioxidant potential of transgenic oil-producing plants such as soybean, sunflower, and corn may be enhanced by overexpressing OsHGGT during seed germination.

Function-related keywords:

• seed ,  development ,  map-based-cloning ,  tolerance ,  cold-tolerance ,  plant-development ,  growth ,  gibberellin ,  Gibberellin ,  seed-germination

Literature:

• Metabolic redesign of vitamin E biosynthesis in plants for tocotrienol production and increased antioxidant content .  DOI:  10.1038/nbt853 ;  PMID:  12897790
• SGD1, a key enzyme in tocopherol biosynthesis, is essential for plant development and cold tolerance in rice .  DOI:  10.1016/j.plantsci.2017.04.008 ;  PMID:  28554480
• Rice tocopherol deficiency 1 encodes a homogentisate phytyltransferase essential for tocopherol biosynthesis and plant development in rice .  DOI:  10.1007/s00299-018-2266-9 ;  PMID:  29427065
• Antioxidant activity and inhibition of lipid peroxidation in germinating seeds of transgenic soybean expressing OsHGGT .  DOI:  10.1021/jf104012z ;  PMID:  21175184

Related News:

Gene Resources:

• NCBI ID: AX046728
• UniProt accessions:

Sequences: