Gene Details:

• MSU gene ID: LOC_Os06g05520
• RAPdb gene ID: Os06g0147800
• Gene Symbol: OsMKK1 OsMEK2
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• By comparing the transcription factors levels between WT and OsMKK1 mutant, OsMKK1 was necessary for salt-induced increase in OsDREB2B and OsMYBS3.
• OsMKK1 activity in the wild-type seedlings and protoplasts was increased by salt stress.
• Taken together, the data suggest that OsMKK1 and OsMPK4 constitute a signaling pathway that regulates salt stress tolerance in rice.
• Yeast two-hybrid and in vitro and in vivo kinase assays revealed that OsMKK1 targeted OsMPK4.
• Further analyses revealed that OsDMI3-mediated phosphorylation of OsMKK1 positively regulates ABA responses in seed germination, root growth, and tolerance to both water stress and oxidative stress.
• The activation of OsMKK1 and its downstream kinase OsMPK1 is dependent on Thr-25 phosphorylation of OsMKK1 in ABA signaling.
• Our results indicate that OsMKK1 is a direct target of OsDMI3, and OsDMI3-mediated phosphorylation of OsMKK1 plays an important role in activating the MAPK cascade and ABA signaling.
• These combined results suggest that OsMEK2 and OsMPK1 expression positively regulates iron- and ROS-dependent ferroptotic cell death, and blast disease (susceptibility)-related cell death was ROS-dependent but iron-independent in rice-M.
• Mitogen-Activated Protein Kinase OsMEK2 and OsMPK1 Signaling Is Required for Ferroptotic Cell Death in Rice- Magnaporthe oryzae Interactions.
• OsFER2 knock-out in wild-type rice HY did not induce ROS and ferric ion (Fe(3+)) accumulation, lipid peroxidation and hypersensitive response (HR) cell death, and also downregulated the defense-related genes OsPAL1, OsPR1-b, OsRbohB, OsNADP-ME2-3, OsMEK2 and OsMPK1, and vacuolar membrane transporter OsVIT2 expression.

Function-related keywords:

• transcription-factor ,  salt ,  salt-stress ,  tolerance ,  stress ,  stress-tolerance ,  Kinase ,  seedlings ,  root ,  seed ,  oxidative-stress ,  seed-germination ,  oxidative ,  ABA ,  kinase ,  root-growth ,  ER-stress ,  disease ,  blast ,  magnaporthe-oryzae ,  cell-death ,  protein-kinase ,  blast-disease ,  transporter

Literature:

• The mitogen-activated protein kinase cascade MKK1-MPK4 mediates salt signaling in rice .  DOI:  10.1016/j.plantsci.2014.08.007 ;  PMID:  25219319
• Rice calcium/calmodulin-dependent protein kinase directly phosphorylates a mitogen-activated protein kinase kinase to regulate abscisic acid responses .  DOI:  10.1093/plcell/koab071 ;  PMID:  33630095
• Mitogen-Activated Protein Kinase OsMEK2 and OsMPK1 Signaling Is Required for Ferroptotic Cell Death in Rice- Magnaporthe oryzae Interactions .  DOI:  10.3389/fpls.2021.710794 ;  PMID:  34408766
• Rice iron storage protein ferritin 2 (OsFER2) positively regulates ferroptotic cell death and defense responses against Magnaporthe oryzae .  DOI:  10.3389/fpls.2022.1019669 ;  PMID:  36352872

Related News:

Gene Resources:

• NCBI ID:
• UniProt accessions:

Sequences: