Information report for LRD6-6;LMR
Gene Details
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Functional Descriptions
- The rice (Oryza sativa L.) LESION MIMIC RESEMBLING, which encodes an AAA-type ATPase, is implicated in defense response.
- The pathogenesis-related (PR) genes PBZ1 and PR1 were induced in LMR, which also showed enhanced resistance to rice blast (Magnaporthe oryzae) and bacterial blight (Xanthomonas oryzae pv. oryzae), suggesting LMR is a negative regulator of cell death in rice.
- The Multivesicular Bodies (MVBs)-Localized AAA ATPase LRD6-6 Inhibits Immunity and Cell Death Likely through Regulating MVBs-Mediated Vesicular Trafficking in Rice.
- Here we report the identification and characterization of a MVBs-localized AAA ATPase LRD6-6 in rice.
- The ATPase activity and homo-dimerization of LRD6-6 is essential for its regulation on plant immunity and cell death.
- Collectively, our study shows that the AAA ATPase LRD6-6 inhibits plant immunity and cell death most likely through modulating MVBs-mediated vesicular trafficking in rice.
- Disruption of LRD6-6 leads to enhanced immunity and cell death in rice.
- The LRD6-6 protein co-localizes with the MVBs marker protein RabF1/ARA6 and interacts with ESCRT-III components OsSNF7 and OsVPS2.
- Further analysis reveals that LRD6-6 is required for MVBs-mediated vesicular trafficking and inhibits the biosynthesis of antimicrobial compounds.
Functional Keywords
- ATPase , defense-response , cell-death , PCD , lesion-mimic , immunity , R-protein , vesicular , vesicular-trafficking
Literature and News
- The rice (Oryza sativa L.) LESION MIMIC RESEMBLING, which encodes an AAA-type ATPase, is implicated in defense response . DOI: 10.1007/s00438-014-0944-z ; PMID: 25367283
- The Multivesicular Bodies (MVBs)-Localized AAA ATPase LRD6-6 Inhibits Immunity and Cell Death Likely through Regulating MVBs-Mediated Vesicular Trafficking in Rice . DOI: 10.1371/journal.pgen.1006311 ; PMID: 27618555
Gene Resources
- UniProt: Q658G8
- EMBL: AK070084, AK119321, AP014962
- AlphaFoldDB: Q658G8
- EnsemblPlants: Os06t0130000-01, Os06t0130000-02
- Gramene: Os06t0130000-01, Os06t0130000-02
- KEGG: osa:4339999
- Orthologous matrix: MVAIERQ
- InterPro: IPR003593, IPR003959, IPR003960
- PANTHER: PTHR23074, PTHR23074:SF86
- SUPFAM: SSF52540
- PROSITE: PS00674
- Gene3D: 1.10.8.60, 1.20.58.80, 3.40.50.300
- OrthoDB: Q658G8
- SWISS-MODEL: Q658G8
- Conserved Domain Database: cd02679, cd19524
- eggNOG: KOG0740
Sequences
cDNA Sequence
- >LOC_Os06g03940.1
AGTGGACGCCCACGCGAATACGCGATCCTCCCCTTCCTCCTCCTCCCCACCAACTCGATCGCGCGTCGCGGAATCCGGATGCTCCCGGCGGCGCTGCTCGCCGTCGGCGCATGAGCTTCCTCCGCGCGCTCGCGGACTCCCTGTCGTCGCTGCTGTACTCGGCGGCTGCGAAGGGGGGAGACATGGACGGGGCCGCGGCGGCGCCGTCGCCGGCGGCGGTGGTGGGGGAGCGCGTGGCGGTGAAGCTCAGGGGATACTTCGAGCTGGCCAAGGAGGAGATCGACAAGGCCGTGCGCGCCGAGGAGTGGGGGCTCCCCGACGACGCCGCCGCGCACTACCGCAACGCGCTCCGCGTCATGCTCGAGGCCAAGGCCGCCCGCGTCCCGGACGCCGTATCCTCCAGCGAGAGGGGGCAGGTTAGGGTCTACCAGGAGAAGATCGCAAAGTGGCAGACTCAGGTGGAGGAACGACTCCGGGTGCTCGGCCAGAGGAGTGGAGCGGCTGCACCAGTGCCAAAGAAGGTTGTTACAAACAATCCTGTTAATAGGAATGACAGAGCCGCATCAACTAGCTTCCATAGGCCTACTTCGCAGCCTAGCCCTACCTTTAATAGAGGTGGTCAAGCATCTTCTCATCAGAAGAGTAGCAGTGGAGGTGCCAAACCTGTGCAAAGAGCTGGTGCAAACTATGATGATAAGCTTGTTGAAATGATAAATACGACCATTGTGGATAGAAGTCCTGCTGTTAAATGGGAAGATGTTGCTGGCCTTGACAAGGCAAAGCAAGCACTCATGGAAATGGTCATTTTACCTACCAAGCGAAGGGATTTGTTTACTGGTCTTCGGAGGCCTGCTAGAGGGCTTCTTCTCTTTGGTCCCCCGGGGAATGGAAAGACGATGCTTGCCAAAGCTGTTGCATCAGAATCTGAAGCAACATTTTTTAATGTTTCAGCTTCTTCACTGACATCAAAGTGGGTAGGAGAGGCTGAAAAGCTTGTACGGACACTCTTCATGGTCGCTGTCGATAGACAACCATCTGTAATTTTTATGGATGAGATTGATAGTGTCATGTCAGCAAGGTTAGCTAATGAGAATGATGCTAGCAGGCGGTTGAAATCTGAATTTCTTATCCAGTTTGATGGGGTCACTTCAAACCCTGATGATCTTGTTATTGTTATAGGTGCTACCAATAAGCCACAAGAGCTGGATGATGCTGTTCTCCGTAGACTGGTAAAGAGAATATATGTGCCATTACCTGATCCAAATGTCCGAAGATTACTGCTGAAAACTCAGCTCAAAGGACAATCATTCAAATTATCCAGTCATGATCTTGAAAGGCTTGCTGCAGATACTGAAGGATATTCCGGGAGTGATCTGAGAGCATTGTGTGAGGAAGCTGCCATGATGCCAATCAGAGAGCTTGGTCCACAAAATATTCTCACTATAAAAGCAAATCAGTTGCGGCCCCTGAAATACGAAGATTTCAAGAAAGCCATGACTGTGATTAGGCCAAGCCTGCAGAAGAGCAAGTGGGACGAGCTAGAGAAATGGAACGAAGAATTTGGTTCAAGTTGACACTAGACAATGGTGCGCCCTATGCATCAGCAGTTTTAATTTGGCCAGTATTACCATCTCCTCAACATAACTATTGGTTTGCAAGTGGTCGCGCGCCCATTCAGGCATTGATATCCCTTGCCATCTGTAACATGTACATGTACAAGAAAACCCTATATTTCATGAGCCATTTGAGAGGGGAAGCTAAAGATGAACTCACGGTGTAAATAAACGCCCATAGCTTCAACCCGTACCAAAACAGTCATGTAAACAAACACTGCTAAAAATTTACATATACCACTGTTCCGTTACTTTCTTTGTACCGTGTGCAGATACTTTCGAATTCCATGCCATATACTGGTATTTCAGTTATCGTCACTT
CDS Sequence
- >LOC_Os06g03940.1
ATGAGCTTCCTCCGCGCGCTCGCGGACTCCCTGTCGTCGCTGCTGTACTCGGCGGCTGCGAAGGGGGGAGACATGGACGGGGCCGCGGCGGCGCCGTCGCCGGCGGCGGTGGTGGGGGAGCGCGTGGCGGTGAAGCTCAGGGGATACTTCGAGCTGGCCAAGGAGGAGATCGACAAGGCCGTGCGCGCCGAGGAGTGGGGGCTCCCCGACGACGCCGCCGCGCACTACCGCAACGCGCTCCGCGTCATGCTCGAGGCCAAGGCCGCCCGCGTCCCGGACGCCGTATCCTCCAGCGAGAGGGGGCAGGTTAGGGTCTACCAGGAGAAGATCGCAAAGTGGCAGACTCAGGTGGAGGAACGACTCCGGGTGCTCGGCCAGAGGAGTGGAGCGGCTGCACCAGTGCCAAAGAAGGTTGTTACAAACAATCCTGTTAATAGGAATGACAGAGCCGCATCAACTAGCTTCCATAGGCCTACTTCGCAGCCTAGCCCTACCTTTAATAGAGGTGGTCAAGCATCTTCTCATCAGAAGAGTAGCAGTGGAGGTGCCAAACCTGTGCAAAGAGCTGGTGCAAACTATGATGATAAGCTTGTTGAAATGATAAATACGACCATTGTGGATAGAAGTCCTGCTGTTAAATGGGAAGATGTTGCTGGCCTTGACAAGGCAAAGCAAGCACTCATGGAAATGGTCATTTTACCTACCAAGCGAAGGGATTTGTTTACTGGTCTTCGGAGGCCTGCTAGAGGGCTTCTTCTCTTTGGTCCCCCGGGGAATGGAAAGACGATGCTTGCCAAAGCTGTTGCATCAGAATCTGAAGCAACATTTTTTAATGTTTCAGCTTCTTCACTGACATCAAAGTGGGTAGGAGAGGCTGAAAAGCTTGTACGGACACTCTTCATGGTCGCTGTCGATAGACAACCATCTGTAATTTTTATGGATGAGATTGATAGTGTCATGTCAGCAAGGTTAGCTAATGAGAATGATGCTAGCAGGCGGTTGAAATCTGAATTTCTTATCCAGTTTGATGGGGTCACTTCAAACCCTGATGATCTTGTTATTGTTATAGGTGCTACCAATAAGCCACAAGAGCTGGATGATGCTGTTCTCCGTAGACTGGTAAAGAGAATATATGTGCCATTACCTGATCCAAATGTCCGAAGATTACTGCTGAAAACTCAGCTCAAAGGACAATCATTCAAATTATCCAGTCATGATCTTGAAAGGCTTGCTGCAGATACTGAAGGATATTCCGGGAGTGATCTGAGAGCATTGTGTGAGGAAGCTGCCATGATGCCAATCAGAGAGCTTGGTCCACAAAATATTCTCACTATAAAAGCAAATCAGTTGCGGCCCCTGAAATACGAAGATTTCAAGAAAGCCATGACTGTGATTAGGCCAAGCCTGCAGAAGAGCAAGTGGGACGAGCTAGAGAAATGGAACGAAGAATTTGGTTCAAGTTGA
Protein Sequence
- >LOC_Os06g03940.1
MSFLRALADSLSSLLYSAAAKGGDMDGAAAAPSPAAVVGERVAVKLRGYFELAKEEIDKAVRAEEWGLPDDAAAHYRNALRVMLEAKAARVPDAVSSSERGQVRVYQEKIAKWQTQVEERLRVLGQRSGAAAPVPKKVVTNNPVNRNDRAASTSFHRPTSQPSPTFNRGGQASSHQKSSSGGAKPVQRAGANYDDKLVEMINTTIVDRSPAVKWEDVAGLDKAKQALMEMVILPTKRRDLFTGLRRPARGLLLFGPPGNGKTMLAKAVASESEATFFNVSASSLTSKWVGEAEKLVRTLFMVAVDRQPSVIFMDEIDSVMSARLANENDASRRLKSEFLIQFDGVTSNPDDLVIVIGATNKPQELDDAVLRRLVKRIYVPLPDPNVRRLLLKTQLKGQSFKLSSHDLERLAADTEGYSGSDLRALCEEAAMMPIRELGPQNILTIKANQLRPLKYEDFKKAMTVIRPSLQKSKWDELEKWNEEFGSS*