Gene Details:

• MSU gene ID: LOC_Os05g02500
• RAPdb gene ID: Os05g0115800
• Gene Symbol: OsMKP1 GSN1 LARGE8 GLA1
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• Unlike the Arabidopsis atmkp1 loss-of-function mutant, which shows no abnormal phenotype without stimuli, OsMKP1 showed a semi-dwarf phenotype.
• Exogenous supply of neither gibberellin nor brassinosteroid complemented the semi-dwarf phenotype of OsMKP1.
• We confirmed that GSN1 is a negative regulator of the OsMKKK10-OsMKK4-OsMPK6 cascade that determines panicle architecture.
• Reduced expression of GSN1 resulted in larger and fewer grains, whereas increased expression resulted in more grains but reduced grain size.
• GSN1 encodes the mitogen-activated protein kinase phosphatase OsMKP1, a dual-specificity phosphatase of unknown function.
• GSN1 directly interacts with and inactivates the mitogen-activated protein kinase OsMPK6 via dephosphorylation.
• Consistent with this finding, the suppression of mitogen-activated protein kinase genes OsMPK6, OsMKK4, and OsMKKK10 separately resulted in denser panicles and smaller grains, which rescued the mutant GSN1 phenotypes.
• LARGE8 encodes the mitogen-activated protein kinase phosphatase1 (OsMKP1).
• Overexpression of GLA1 caused a decrease in grain length, and the GLA1 protein interacted with OsMAPK6.
• These results suggest that GLA1 may serve as a negative regulator of the OsMAPKK4-OsMAPK6 cascade, controlling grain size via the dephosphorylation of OsMAPK6.
• The GLA1 mutation was mapped to a single-nucleotide polymorphism in a gene encoding a cytoplasmically-localized mitogen-activated protein kinase (MAPK) phosphatase.

Function-related keywords:

• dwarf ,  brassinosteroid ,  gibberellin ,  panicle ,  grain ,  grain-size ,  architecture ,  Kinase ,  panicle-architecture ,  protein-kinase ,  grain-length

Literature:

• A calmodulin-binding mitogen-activated protein kinase phosphatase is induced by wounding and regulates the activities of stress-related mitogen-activated protein kinases in rice .  DOI:  10.1093/pcp/pcm007 ;  PMID:  17218330
• GRAIN SIZE AND NUMBER1 Negatively Regulates the OsMKKK10-OsMKK4-OsMPK6 Cascade to Coordinate the Trade-off between Grain Number per Panicle and Grain Size in Rice .  DOI:  10.1105/tpc.17.00959 ;  PMID:  29588389
• A mitogen-activated protein kinase phosphatase influences grain size and weight in rice .  DOI:  10.1111/tpj.13971 ;  PMID:  29775492
• GRAIN LENGTH AND AWN 1 negatively regulates grain size in rice .  DOI:  10.1111/jipb.12736 ;  PMID:  30414306
• OrMKK3 Influences Morphology and Grain Size in Rice .  DOI:  10.1007/s12374-020-09290-2 ;  PMID:  33424241
• An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants .  DOI:  10.1126/sciadv.abg8723 ;  PMID:  35263144

Related News:

Gene Resources:

• NCBI ID:
• UniProt accessions:

Sequences: