Gene Details:

• MSU gene ID: LOC_Os04g53120
• RAPdb gene ID: None
• Gene Symbol: Xa1
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• Expression of Xa1, a bacterial blight-resistance gene in rice, is induced by bacterial inoculation.
• The deduced amino acid sequence of the Xa1 gene product contains nucleotide binding sites (NBS) and a new type of leucine-rich repeats (LRR); thus, Xa1 is a member of the NBS-LRR class of plant disease-resistance genes, but quite different from Xa21, another BB-resistance gene isolated from rice.
• However, the iTALEs present in many isolates interfere with the otherwise broad-spectrum resistance conferred by Xa1.
• Although Xa1-2 and Xa14 conferred different resistance spectra, their performance could be attenuated by iTALEs, as has previously been reported for Xa1.
• Here, we report the isolation of three new bacterial blight R genes in rice, Xa1-2, Xa14, and Xa31(t), which were allelic to Xa1 and encoded atypical NLRs with unique central tandem repeats (CTRs).
• Xa1 Allelic R Genes Activate Rice Blight Resistance Suppressed by Interfering TAL Effectors.
• One mechanism involves the nucleotide-binding leucine-rich repeat (NLR) resistance gene Xa1 and TALEs.
• Reciprocally, Xoo has evolved TALE variants, C-terminally truncated versions (interfering TALEs or iTALEs), to overcome Xa1 resistance.
• On the other hand, iTALEs could suppress the resistance mediated by Xa1 allelic R genes, and iTALE genes were prevalent (95%) in Asian, but not in African Xoo strains.
• Our findings demonstrate the prominence of a defense mechanism in which rice depends on Xa1 alleles and a counteracting mechanism in which Xoo relies on iTALEs for BB.

Function-related keywords:

• bacterial-blight ,  blight ,  disease ,  resistance ,  defense ,  xoo

Literature:

• Identification of a YAC clone carrying the Xa-1 allele, a bacterial blight resistance gene in rice .  DOI:  10.1007/BF00225736 ;  PMID:  24162208
• Expression of Xa1, a bacterial blight-resistance gene in rice, is induced by bacterial inoculation .  DOI:  10.1073/pnas.95.4.1663 ;  PMID:  9465073
• Interfering TAL effectors of Xanthomonas oryzae neutralize R-gene-mediated plant disease resistance .  DOI:  10.1038/ncomms13435 ;  PMID:  27811915
• Multiple Alleles Encoding Atypical NLRs with Unique Central Tandem Repeats in Rice Confer Resistance to Xanthomonas oryzae pv. oryzae .  DOI:  10.1016/j.xplc.2020.100088 ;  PMID:  33367251
• Xa1 Allelic R Genes Activate Rice Blight Resistance Suppressed by Interfering TAL Effectors .  DOI:  10.1016/j.xplc.2020.100087 ;  PMID:  33367250
• Rapid genotyping of bacterial leaf blight resistant genes of rice using loop-mediated isothermal amplification assay .  DOI:  10.1007/s11033-020-06077-z ;  PMID:  33394228

Related News:

Gene Resources:

• NCBI ID: AB506464  , AB002266
• UniProt accessions:

Sequences: