Gene Details:
- MSU gene ID: LOC_Os04g38480
- RAPdb gene ID: Os04g0457800
- Gene Symbol: SERK2 OsSERK2
- Genome: MSU7 , IRGSP-1.0
- Species: Oryza sativa
Functional Descriptions:
- Four tyrosine residues of the rice immune receptor XA21 are not required for interaction with the co-receptor OsSERK2 or resistance to Xanthomonas oryzae pv. oryzae.
- Regulation of Brassinosteroid Signaling and Salt Resistance by SERK2 and Potential Utilization for Crop Improvement in Rice.
- We generated multiple mutant alleles of SERK2 by CRISPR/Cas9 editing and show that knockout of SERK2 results in a compact structure accompanied with increased grain size.
- By contrast, overexpression of SERK2 significantly enhances grain size and salt stress resistance, importantly, without affecting plant architecture.
- Furthermore, while salt suppresses SERK2 transcription, the protein is greatly induced by salt stress.
- Here, we show that SERK2 as a BR signaling component is a potentially useful candidate for BR manipulation in rice.
- SERK2 is localized on plasma membrane and can interact with OsBRI1, the BR receptor, suggesting its conserved role as co-receptor in BR signaling.
- Taken together, we propose that the adverse condition induces SERK2 accumulation to enhance early BR signaling on plasma membrane in favor of the anti-stress response.
- Our results illustrate the great potentials of specific BR components such as SERK2 for crop improvement by utilizing flexible strategies.
Function-related keywords:
- resistance , grain , salt , grain-size , salt-stress , stress , architecture , brassinosteroid , BR , Brassinosteroid , BR-signaling , plasma-membrane , Brassinosteroid-Signaling , plant-architecture , stress-response
Literature:
- Expression of SERK family receptor-like protein kinase genes in rice . DOI: 10.1016/j.bbaexp.2005.06.007 ; PMID: 16081169
- Engineering OsBAK1 gene as a molecular tool to improve rice architecture for high yield . DOI: 10.1111/j.1467-7652.2009.00444.x ; PMID: 19754838
- An XA21-associated kinase (OsSERK2) regulates immunity mediated by the XA21 and XA3 immune receptors . DOI: 10.1093/mp/ssu003 ; PMID: 24482436
- A subset of OsSERK genes, including OsBAK1, affects normal growth and leaf development of rice . DOI: 10.1007/s10059-011-0178-4 ; PMID: 22058019
- Structure of the OsSERK2 leucine-rich repeat extracellular domain . DOI: 10.1107/S1399004714021178 ; PMID: 25372696
- The Xanthomonas effector XopK harbours E3 ubiquitin-ligase activity that is required for virulence . DOI: 10.1111/nph.15287 ; PMID: 29949665
- Four tyrosine residues of the rice immune receptor XA21 are not required for interaction with the co-receptor OsSERK2 or resistance to Xanthomonas oryzae pv. oryzae . DOI: 10.7717/peerj.6074 ; PMID: 30581670
- Regulation of Brassinosteroid Signaling and Salt Resistance by SERK2 and Potential Utilization for Crop Improvement in Rice . DOI: 10.3389/fpls.2020.621859 ; PMID: 33362843
Related News:
Gene Resources:
Sequences:
cDNA Sequence
- >LOC_Os04g38480.1
GGTAAAAAAAAAAGGAGAGAGAGAGGAGAGACAGGTCGCTTCCTGCTTCCATTGGAGAAGAGGAGAGGAGAGGAGAGGAGACCGAGCCGGCGGCGGCGGCGACGAGGAGAGGGAGCTGATCGGGCGGTCCCCCCCTTTGCCGAGGGGACGCCGGCGGCCTCCGGGTTGGGTCCACTTGGCAGCGGTGAGCGGCGGCGGGGGATGGCGGAGGCGCGGCTGCTGCGGCGGCGGCGGCTGTGCTTGGCGGTGCCGTTCGTGTGGGTGGTGGCGGTGGCCGTGAGCCGGGTCGGCGCCAACACGGAGGGTGATGCCCTATATAGTCTGCGCCAAAGTCTGAAAGATGCTAACAATGTGCTGCAGAGTTGGGATCCCACTCTGGTCAATCCATGCACATGGTTCCATGTAACTTGTAACCCTGACAACAGCGTGATCAGAGTTGATCTTGGAAATGCACAACTGTCAGGTGCATTGGTTCCCCAGCTTGGGCAGTTGAAAAATCTGCAATATCTGGAGCTTTACAGCAACAACATAAGTGGGACAATACCTAATGAACTGGGAAACTTAACTAACTTGGTCAGTTTGGATCTTTACCTGAACAACTTCACTGGTTTTATTCCGGAAACCTTGGGGCAACTCTACAAGCTGCGTTTCCTTCGTCTTAACAACAACAGTCTTTCTGGTTCAATTCCAAAATCCTTGACCAATATCACTACTCTTCAAGTTCTGGATCTCTCAAATAACAATCTCTCAGGAGAGGTTCCGTCTACTGGCTCCTTTTCACTCTTTACCCCTATAAGTTTTGCTAATAATAAAGATCTTTGTGGCCCGGGTACTACAAAACCCTGCCCTGGAGCTCCACCTTTTTCTCCACCACCTCCTTTCAATCCCCCAACACCTACTGTGTCACAAGGTGACTCCAAAACTGGAGCAATTGCTGGAGGTGTTGCTGCAGCTGCTGCATTGCTGTTTGCGGTTCCGGCAATTGGATTTGCATGGTGGCGGCGGCGTAAACCTGAAGAACACTTCTTTGATGTCCCTGCTGAGGAGGATCCGGAAGTGCACCTTGGCCAACTTAAGAGATTCTCACTCCGGGAGCTTCAAGTTGCTACTGATAACTTTAGCAATAAGAATATTCTGGGAAGAGGTGGCTTTGGAAAGGTGTACAAAGGTAGACTGGCAGATGGCTCGTTGGTAGCAGTGAAAAGATTAAAAGAAGAACGTACCCCTGGTGGTGAGCTCCAGTTCCAAACAGAAGTTGAAATGATTAGCATGGCGGTGCATAGGAACCTGCTTCGGCTCCGTGGATTTTGCATGACGCCTACAGAACGGTTACTTGTCTATCCCTACATGGCTAATGGGAGTGTCGCATCACGATTGCGAGAGCGGCAGCCAAATGATCCGCCGCTTGAATGGCAAACAAGAACTCGGATTGCGCTGGGATCTGCCAGAGGATTGTCCTACTTGCACGACCATTGTGATCCCAAGATCATTCATCGTGATGTCAAAGCTGCAAATATTCTGTTGGATGAAGATTTTGAGGCAGTCGTGGGTGACTTTGGACTGGCCAAACTTATGGATTACAAGGACACTCATGTAACCACAGCTGTTCGTGGGACGATCGGACACATTGCTCCTGAGTACCTCTCTACTGGGAAGTCCTCTGAGAAGACTGATGTTTTTGGCTATGGAATCATGCTTCTTGAGCTCATTACAGGACAAAGGGCATTTGATCTTGCTCGTCTTGCAAACGATGATGATGTGATGTTGCTCGATTGGGTGAAAGGGCTCCTGAAAGAGAAGAAGGTGGAGATGCTGGTGGACCCGGACCTCCAGAGCGGCTTCGTGGAGCATGAGGTGGAGTCACTCATCCAGGTGGCTCTGCTCTGCACGCAGGGCTCCCCGATGGACCGGCCCAAGATGTCGGAGGTGGTGAGGATGCTGGAGGGCGATGGCCTCGCGGAGCGGTGGGAGGAGTGGCAGAAGGTGGAGGTGGTCCGGCAGGAGGCGGAGCTGGCCCCCCGCCACAACGACTGGATCGTCGACTCGACCTACAATCTCCGGGCAATGGAGCTGTCCGGCCCGAGGTAAAAGAAACGAAAGACAAAATCACAAAGCATCCAACCTTTGCTCGACGGCTTCCTCGCCCTTGTTTGTGTATATGACAGACAGATCGATAGCTGGCAAATCTGGAGGGAAAAATGGTTTACTTGTAACCCTCCCTGGTGCCTCGGTAATTTTCAAGTAGGCTCTGCACTTGGTTGTCGTTAGAAATGCATGGCCGGGCGGAATTGCAACACATTGTTGTGGCGGCTCTGCGTCTGTAATGGCTGAACAACTGATGCCTCTCTCTCTGCTGTATTGTACGTACAACTCTCTCTTTTGACGGTGCTAAACATCCTAGGCAATCTTTTTTGGTCTCCCGGGTCACACCGTGTCCGCCTGTACTTTGTTACTCTTCGTTGAAAAACTATACTGGTAGCAAACTCAACTCTTTATCTGAAAAAAA - >LOC_Os04g38480.2
GGTAAAAAAAAAAGGAGAGAGAGAGGAGAGACAGGTCGCTTCCTGCTTCCATTGGAGAAGAGGAGAGGAGAGGAGAGGAGACCGAGCCGGCGGCGGCGGCGACGAGGAGAGGGAGCTGATCGGGCGGTCCCCCCCTTTGCCGAGGGGACGCCGGCGGCCTCCGGGTTGGGTCCACTTGGCAGCGGTGAGCGGCGGCGGGGGATGGCGGAGGCGCGGCTGCTGCGGCGGCGGCGGCTGTGCTTGGCGGTGCCGTTCGTGTGGGTGGTGGCGGTGGCCGTGAGCCGGGTCGGCGCCAACACGGAGGGTGATGCCCTATATAGTCTGCGCCAAAGTCTGAAAGATGCTAACAATGTGCTGCAGAGTTGGGATCCCACTCTGGTCAATCCATGCACATGGTTCCATGTAACTTGTAACCCTGACAACAGCGTGATCAGAGTTGATCTTGGAAATGCACAACTGTCAGGTGCATTGGTTCCCCAGCTTGGGCAGTTGAAAAATCTGCAATATCTGGAGCTTTACAGCAACAACATAAGTGGGACAATACCTAATGAACTGGGAAACTTAACTAACTTGGTCAGTTTGGATCTTTACCTGAACAACTTCACTGGTTTTATTCCGGAAACCTTGGGGCAACTCTACAAGCTGCGTTTCCTTCGTCTTAACAACAACAGTCTTTCTGGTTCAATTCCAAAATCCTTGACCAATATCACTACTCTTCAAGTTCTGGATCTCTCAAATAACAATCTCTCAGGAGAGGTTCCGTCTACTGGCTCCTTTTCACTCTTTACCCCTATAAGTTTTGCTAATAATAAAGATCTTTGTGGCCCGGGTACTACAAAACCCTGCCCTGGAGCTCCACCTTTTTCTCCACCACCTCCTTTCAATCCCCCAACACCTACTGTGTCACAAGGTGACTCCAAAACTGGAGCAATTGCTGGAGGTGTTGCTGCAGCTGCTGCATTGCTGTTTGCGGTTCCGGCAATTGGATTTGCATGGTGGCGGCGGCGTAAACCTGAAGAACACTTCTTTGATGTCCCTGCTGAGGAGGATCCGGAAGTGCACCTTGGCCAACTTAAGAGATTCTCACTCCGGGAGCTTCAAGTTGCTACTGATAACTTTAGCAATAAGAATATTCTGGGAAGAGGTGGCTTTGGAAAGGTGTACAAAGGTAGACTGGCAGATGGCTCGTTGGTAGCAGTGAAAAGATTAAAAGAAGAACGTACCCCTGGTGGTGAGCTCCAGTTCCAAACAGAAGTTGAAATGATTAGCATGGCGGTGCATAGGAACCTGCTTCGGCTCCGTGGATTTTGCATGACGCCTACAGAACGGTTACTTGTCTATCCCTACATGGCTAATGGGAGTGTCGCATCACGATTGCGAGAGCGGCAGCCAAATGATCCGCCGCTTGAATGGCAAACAAGAACTCGGATTGCGCTGGGATCTGCCAGAGGATTGTCCTACTTGCACGACCATTGTGATCCCAAGATCATTCATCGTGATGTCAAAGCTGCAAATATTCTGTTGGATGAAGATTTTGAGGCAGTCGTGGGTGACTTTGGACTGGCCAAACTTATGGATTACAAGGACACTCATGTAACCACAGCTGTTCGTGGGACGATCGGACACATTGCTCCTGAGTACCTCTCTACTGGGAAGTCCTCTGAGAAGACTGATGTTTTTGGCTATGGAATCATGCTTCTTGAGCTCATTACAGGACAAAGGGCATTTGATCTTGCTCGTCTTGCAAACGATGATGATGTGATGTTGCTCGATTGGGTGAAAGGGCTCCTGAAAGAGAAGAAGGTGGAGATGCTGGTGGACCCGGACCTCCAGAGCGGCTTCGTGGAGCATGAGGTGGAGTCACTCATCCAGGTGGCTCTGCTCTGCACGCAGGGCTCCCCGATGGACCGGCCCAAGATGTCGGAGGTGGTGAGGATGCTGGAGGGCGATGGCCTCGCGGAGCGGTGGGAGGAGTGGCAGAAGGTGGAGGTGGTCCGGCAGGAGGCGGAGCTGGCCCCCCGCCACAACGACTGGATCGTCGACTCGACCTACAATCTCCGGGCAATGGAGCTGTCCGGCCCGAGGTAAAAGAAACGAAAGACAAAATCACAAAGCATCCAACCTTTGCTCGACGGCTTCCTCGCCCTTGTTTGTGTATATGACAGACAGATCGATAGCTGGCAAATCTGGAGGGAAAAATGGTTTACTTGTAACCCTCCCTGGTGCCTCGGTAATTTTCAAGTAGGCTCTGCACTTGGTTGTCGTTAGAAATGCATGGCCGGGCGGAATTGCAACACATTGTTGTGGCGGCTCTGCGTCTGTAATGGCTGAACAACTGATGCCTCTCTCTCTGCTGTATTGTACGTACAACTCTCTCTTTTGACGGTGCTAAACATCCTAGGCAATCTTTTTTGGTCTCCCGGGTCACACCGTGTCCGCCTGTACTTTGTTACTCTTCGTTGAAAAACTATACTGGTAGCAAACTCAACTCTTTATCTGAAAAAAA
CDS Sequence
- >LOC_Os04g38480.1
ATGGCGGAGGCGCGGCTGCTGCGGCGGCGGCGGCTGTGCTTGGCGGTGCCGTTCGTGTGGGTGGTGGCGGTGGCCGTGAGCCGGGTCGGCGCCAACACGGAGGGTGATGCCCTATATAGTCTGCGCCAAAGTCTGAAAGATGCTAACAATGTGCTGCAGAGTTGGGATCCCACTCTGGTCAATCCATGCACATGGTTCCATGTAACTTGTAACCCTGACAACAGCGTGATCAGAGTTGATCTTGGAAATGCACAACTGTCAGGTGCATTGGTTCCCCAGCTTGGGCAGTTGAAAAATCTGCAATATCTGGAGCTTTACAGCAACAACATAAGTGGGACAATACCTAATGAACTGGGAAACTTAACTAACTTGGTCAGTTTGGATCTTTACCTGAACAACTTCACTGGTTTTATTCCGGAAACCTTGGGGCAACTCTACAAGCTGCGTTTCCTTCGTCTTAACAACAACAGTCTTTCTGGTTCAATTCCAAAATCCTTGACCAATATCACTACTCTTCAAGTTCTGGATCTCTCAAATAACAATCTCTCAGGAGAGGTTCCGTCTACTGGCTCCTTTTCACTCTTTACCCCTATAAGTTTTGCTAATAATAAAGATCTTTGTGGCCCGGGTACTACAAAACCCTGCCCTGGAGCTCCACCTTTTTCTCCACCACCTCCTTTCAATCCCCCAACACCTACTGTGTCACAAGGTGACTCCAAAACTGGAGCAATTGCTGGAGGTGTTGCTGCAGCTGCTGCATTGCTGTTTGCGGTTCCGGCAATTGGATTTGCATGGTGGCGGCGGCGTAAACCTGAAGAACACTTCTTTGATGTCCCTGCTGAGGAGGATCCGGAAGTGCACCTTGGCCAACTTAAGAGATTCTCACTCCGGGAGCTTCAAGTTGCTACTGATAACTTTAGCAATAAGAATATTCTGGGAAGAGGTGGCTTTGGAAAGGTGTACAAAGGTAGACTGGCAGATGGCTCGTTGGTAGCAGTGAAAAGATTAAAAGAAGAACGTACCCCTGGTGGTGAGCTCCAGTTCCAAACAGAAGTTGAAATGATTAGCATGGCGGTGCATAGGAACCTGCTTCGGCTCCGTGGATTTTGCATGACGCCTACAGAACGGTTACTTGTCTATCCCTACATGGCTAATGGGAGTGTCGCATCACGATTGCGAGAGCGGCAGCCAAATGATCCGCCGCTTGAATGGCAAACAAGAACTCGGATTGCGCTGGGATCTGCCAGAGGATTGTCCTACTTGCACGACCATTGTGATCCCAAGATCATTCATCGTGATGTCAAAGCTGCAAATATTCTGTTGGATGAAGATTTTGAGGCAGTCGTGGGTGACTTTGGACTGGCCAAACTTATGGATTACAAGGACACTCATGTAACCACAGCTGTTCGTGGGACGATCGGACACATTGCTCCTGAGTACCTCTCTACTGGGAAGTCCTCTGAGAAGACTGATGTTTTTGGCTATGGAATCATGCTTCTTGAGCTCATTACAGGACAAAGGGCATTTGATCTTGCTCGTCTTGCAAACGATGATGATGTGATGTTGCTCGATTGGGTGAAAGGGCTCCTGAAAGAGAAGAAGGTGGAGATGCTGGTGGACCCGGACCTCCAGAGCGGCTTCGTGGAGCATGAGGTGGAGTCACTCATCCAGGTGGCTCTGCTCTGCACGCAGGGCTCCCCGATGGACCGGCCCAAGATGTCGGAGGTGGTGAGGATGCTGGAGGGCGATGGCCTCGCGGAGCGGTGGGAGGAGTGGCAGAAGGTGGAGGTGGTCCGGCAGGAGGCGGAGCTGGCCCCCCGCCACAACGACTGGATCGTCGACTCGACCTACAATCTCCGGGCAATGGAGCTGTCCGGCCCGAGGTAA - >LOC_Os04g38480.2
ATGGCGGAGGCGCGGCTGCTGCGGCGGCGGCGGCTGTGCTTGGCGGTGCCGTTCGTGTGGGTGGTGGCGGTGGCCGTGAGCCGGGTCGGCGCCAACACGGAGGGTGATGCCCTATATAGTCTGCGCCAAAGTCTGAAAGATGCTAACAATGTGCTGCAGAGTTGGGATCCCACTCTGGTCAATCCATGCACATGGTTCCATGTAACTTGTAACCCTGACAACAGCGTGATCAGAGTTGATCTTGGAAATGCACAACTGTCAGGTGCATTGGTTCCCCAGCTTGGGCAGTTGAAAAATCTGCAATATCTGGAGCTTTACAGCAACAACATAAGTGGGACAATACCTAATGAACTGGGAAACTTAACTAACTTGGTCAGTTTGGATCTTTACCTGAACAACTTCACTGGTTTTATTCCGGAAACCTTGGGGCAACTCTACAAGCTGCGTTTCCTTCGTCTTAACAACAACAGTCTTTCTGGTTCAATTCCAAAATCCTTGACCAATATCACTACTCTTCAAGTTCTGGATCTCTCAAATAACAATCTCTCAGGAGAGGTTCCGTCTACTGGCTCCTTTTCACTCTTTACCCCTATAAGTTTTGCTAATAATAAAGATCTTTGTGGCCCGGGTACTACAAAACCCTGCCCTGGAGCTCCACCTTTTTCTCCACCACCTCCTTTCAATCCCCCAACACCTACTGTGTCACAAGGTGACTCCAAAACTGGAGCAATTGCTGGAGGTGTTGCTGCAGCTGCTGCATTGCTGTTTGCGGTTCCGGCAATTGGATTTGCATGGTGGCGGCGGCGTAAACCTGAAGAACACTTCTTTGATGTCCCTGCTGAGGAGGATCCGGAAGTGCACCTTGGCCAACTTAAGAGATTCTCACTCCGGGAGCTTCAAGTTGCTACTGATAACTTTAGCAATAAGAATATTCTGGGAAGAGGTGGCTTTGGAAAGGTGTACAAAGGTAGACTGGCAGATGGCTCGTTGGTAGCAGTGAAAAGATTAAAAGAAGAACGTACCCCTGGTGGTGAGCTCCAGTTCCAAACAGAAGTTGAAATGATTAGCATGGCGGTGCATAGGAACCTGCTTCGGCTCCGTGGATTTTGCATGACGCCTACAGAACGGTTACTTGTCTATCCCTACATGGCTAATGGGAGTGTCGCATCACGATTGCGAGAGCGGCAGCCAAATGATCCGCCGCTTGAATGGCAAACAAGAACTCGGATTGCGCTGGGATCTGCCAGAGGATTGTCCTACTTGCACGACCATTGTGATCCCAAGATCATTCATCGTGATGTCAAAGCTGCAAATATTCTGTTGGATGAAGATTTTGAGGCAGTCGTGGGTGACTTTGGACTGGCCAAACTTATGGATTACAAGGACACTCATGTAACCACAGCTGTTCGTGGGACGATCGGACACATTGCTCCTGAGTACCTCTCTACTGGGAAGTCCTCTGAGAAGACTGATGTTTTTGGCTATGGAATCATGCTTCTTGAGCTCATTACAGGACAAAGGGCATTTGATCTTGCTCGTCTTGCAAACGATGATGATGTGATGTTGCTCGATTGGGTGAAAGGGCTCCTGAAAGAGAAGAAGGTGGAGATGCTGGTGGACCCGGACCTCCAGAGCGGCTTCGTGGAGCATGAGGTGGAGTCACTCATCCAGGTGGCTCTGCTCTGCACGCAGGGCTCCCCGATGGACCGGCCCAAGATGTCGGAGGTGGTGAGGATGCTGGAGGGCGATGGCCTCGCGGAGCGGTGGGAGGAGTGGCAGAAGGTGGAGGTGGTCCGGCAGGAGGCGGAGCTGGCCCCCCGCCACAACGACTGGATCGTCGACTCGACCTACAATCTCCGGGCAATGGAGCTGTCCGGCCCGAGGTAA
Protein Sequence
- >LOC_Os04g38480.1
MAEARLLRRRRLCLAVPFVWVVAVAVSRVGANTEGDALYSLRQSLKDANNVLQSWDPTLVNPCTWFHVTCNPDNSVIRVDLGNAQLSGALVPQLGQLKNLQYLELYSNNISGTIPNELGNLTNLVSLDLYLNNFTGFIPETLGQLYKLRFLRLNNNSLSGSIPKSLTNITTLQVLDLSNNNLSGEVPSTGSFSLFTPISFANNKDLCGPGTTKPCPGAPPFSPPPPFNPPTPTVSQGDSKTGAIAGGVAAAAALLFAVPAIGFAWWRRRKPEEHFFDVPAEEDPEVHLGQLKRFSLRELQVATDNFSNKNILGRGGFGKVYKGRLADGSLVAVKRLKEERTPGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASRLRERQPNDPPLEWQTRTRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEDFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGIMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKVEMLVDPDLQSGFVEHEVESLIQVALLCTQGSPMDRPKMSEVVRMLEGDGLAERWEEWQKVEVVRQEAELAPRHNDWIVDSTYNLRAMELSGPR* - >LOC_Os04g38480.2
MAEARLLRRRRLCLAVPFVWVVAVAVSRVGANTEGDALYSLRQSLKDANNVLQSWDPTLVNPCTWFHVTCNPDNSVIRVDLGNAQLSGALVPQLGQLKNLQYLELYSNNISGTIPNELGNLTNLVSLDLYLNNFTGFIPETLGQLYKLRFLRLNNNSLSGSIPKSLTNITTLQVLDLSNNNLSGEVPSTGSFSLFTPISFANNKDLCGPGTTKPCPGAPPFSPPPPFNPPTPTVSQGDSKTGAIAGGVAAAAALLFAVPAIGFAWWRRRKPEEHFFDVPAEEDPEVHLGQLKRFSLRELQVATDNFSNKNILGRGGFGKVYKGRLADGSLVAVKRLKEERTPGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASRLRERQPNDPPLEWQTRTRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEDFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGIMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKVEMLVDPDLQSGFVEHEVESLIQVALLCTQGSPMDRPKMSEVVRMLEGDGLAERWEEWQKVEVVRQEAELAPRHNDWIVDSTYNLRAMELSGPR*