Information report for SERK2;OsSERK2
Gene Details
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Functional Descriptions
- Four tyrosine residues of the rice immune receptor XA21 are not required for interaction with the co-receptor OsSERK2 or resistance to Xanthomonas oryzae pv. oryzae.
- Regulation of Brassinosteroid Signaling and Salt Resistance by SERK2 and Potential Utilization for Crop Improvement in Rice.
- We generated multiple mutant alleles of SERK2 by CRISPR/Cas9 editing and show that knockout of SERK2 results in a compact structure accompanied with increased grain size.
- By contrast, overexpression of SERK2 significantly enhances grain size and salt stress resistance, importantly, without affecting plant architecture.
- Furthermore, while salt suppresses SERK2 transcription, the protein is greatly induced by salt stress.
- Here, we show that SERK2 as a BR signaling component is a potentially useful candidate for BR manipulation in rice.
- SERK2 is localized on plasma membrane and can interact with OsBRI1, the BR receptor, suggesting its conserved role as co-receptor in BR signaling.
- Taken together, we propose that the adverse condition induces SERK2 accumulation to enhance early BR signaling on plasma membrane in favor of the anti-stress response.
- Our results illustrate the great potentials of specific BR components such as SERK2 for crop improvement by utilizing flexible strategies.
Functional Keywords
Literature and News
- Expression of SERK family receptor-like protein kinase genes in rice . DOI: 10.1016/j.bbaexp.2005.06.007 ; PMID: 16081169
- Engineering OsBAK1 gene as a molecular tool to improve rice architecture for high yield . DOI: 10.1111/j.1467-7652.2009.00444.x ; PMID: 19754838
- An XA21-associated kinase (OsSERK2) regulates immunity mediated by the XA21 and XA3 immune receptors . DOI: 10.1093/mp/ssu003 ; PMID: 24482436
- A subset of OsSERK genes, including OsBAK1, affects normal growth and leaf development of rice . DOI: 10.1007/s10059-011-0178-4 ; PMID: 22058019
- Structure of the OsSERK2 leucine-rich repeat extracellular domain . DOI: 10.1107/S1399004714021178 ; PMID: 25372696
- The Xanthomonas effector XopK harbours E3 ubiquitin-ligase activity that is required for virulence . DOI: 10.1111/nph.15287 ; PMID: 29949665
- Four tyrosine residues of the rice immune receptor XA21 are not required for interaction with the co-receptor OsSERK2 or resistance to Xanthomonas oryzae pv. oryzae . DOI: 10.7717/peerj.6074 ; PMID: 30581670
- Regulation of Brassinosteroid Signaling and Salt Resistance by SERK2 and Potential Utilization for Crop Improvement in Rice . DOI: 10.3389/fpls.2020.621859 ; PMID: 33362843
Gene Resources
- UniProt: Q7XV05
- EMBL: AL606636, AP008210, AP014960
- AlphaFoldDB: Q7XV05
- EnsemblPlants: Os04t0457800-01
- Gramene: Os04t0457800-01
- KEGG: dosa:Os04g0457800, osa:4336035
- Orthologous matrix: ASLRWWW
- InterPro: IPR000719, IPR001245, IPR008271
- PANTHER: PTHR47988
- SUPFAM: SSF52058, SSF56112
- PROSITE: PS00107, PS00108, PS50011
- Gene3D: 1.10.510.10, 3.30.200.20, 3.80.10.10
- OrthoDB: Q7XV05
- SWISS-MODEL: Q7XV05
- eggNOG: ENOG502QQ7B
Sequences
cDNA Sequence
- >LOC_Os04g38480.1
GGTAAAAAAAAAAGGAGAGAGAGAGGAGAGACAGGTCGCTTCCTGCTTCCATTGGAGAAGAGGAGAGGAGAGGAGAGGAGACCGAGCCGGCGGCGGCGGCGACGAGGAGAGGGAGCTGATCGGGCGGTCCCCCCCTTTGCCGAGGGGACGCCGGCGGCCTCCGGGTTGGGTCCACTTGGCAGCGGTGAGCGGCGGCGGGGGATGGCGGAGGCGCGGCTGCTGCGGCGGCGGCGGCTGTGCTTGGCGGTGCCGTTCGTGTGGGTGGTGGCGGTGGCCGTGAGCCGGGTCGGCGCCAACACGGAGGGTGATGCCCTATATAGTCTGCGCCAAAGTCTGAAAGATGCTAACAATGTGCTGCAGAGTTGGGATCCCACTCTGGTCAATCCATGCACATGGTTCCATGTAACTTGTAACCCTGACAACAGCGTGATCAGAGTTGATCTTGGAAATGCACAACTGTCAGGTGCATTGGTTCCCCAGCTTGGGCAGTTGAAAAATCTGCAATATCTGGAGCTTTACAGCAACAACATAAGTGGGACAATACCTAATGAACTGGGAAACTTAACTAACTTGGTCAGTTTGGATCTTTACCTGAACAACTTCACTGGTTTTATTCCGGAAACCTTGGGGCAACTCTACAAGCTGCGTTTCCTTCGTCTTAACAACAACAGTCTTTCTGGTTCAATTCCAAAATCCTTGACCAATATCACTACTCTTCAAGTTCTGGATCTCTCAAATAACAATCTCTCAGGAGAGGTTCCGTCTACTGGCTCCTTTTCACTCTTTACCCCTATAAGTTTTGCTAATAATAAAGATCTTTGTGGCCCGGGTACTACAAAACCCTGCCCTGGAGCTCCACCTTTTTCTCCACCACCTCCTTTCAATCCCCCAACACCTACTGTGTCACAAGGTGACTCCAAAACTGGAGCAATTGCTGGAGGTGTTGCTGCAGCTGCTGCATTGCTGTTTGCGGTTCCGGCAATTGGATTTGCATGGTGGCGGCGGCGTAAACCTGAAGAACACTTCTTTGATGTCCCTGCTGAGGAGGATCCGGAAGTGCACCTTGGCCAACTTAAGAGATTCTCACTCCGGGAGCTTCAAGTTGCTACTGATAACTTTAGCAATAAGAATATTCTGGGAAGAGGTGGCTTTGGAAAGGTGTACAAAGGTAGACTGGCAGATGGCTCGTTGGTAGCAGTGAAAAGATTAAAAGAAGAACGTACCCCTGGTGGTGAGCTCCAGTTCCAAACAGAAGTTGAAATGATTAGCATGGCGGTGCATAGGAACCTGCTTCGGCTCCGTGGATTTTGCATGACGCCTACAGAACGGTTACTTGTCTATCCCTACATGGCTAATGGGAGTGTCGCATCACGATTGCGAGAGCGGCAGCCAAATGATCCGCCGCTTGAATGGCAAACAAGAACTCGGATTGCGCTGGGATCTGCCAGAGGATTGTCCTACTTGCACGACCATTGTGATCCCAAGATCATTCATCGTGATGTCAAAGCTGCAAATATTCTGTTGGATGAAGATTTTGAGGCAGTCGTGGGTGACTTTGGACTGGCCAAACTTATGGATTACAAGGACACTCATGTAACCACAGCTGTTCGTGGGACGATCGGACACATTGCTCCTGAGTACCTCTCTACTGGGAAGTCCTCTGAGAAGACTGATGTTTTTGGCTATGGAATCATGCTTCTTGAGCTCATTACAGGACAAAGGGCATTTGATCTTGCTCGTCTTGCAAACGATGATGATGTGATGTTGCTCGATTGGGTGAAAGGGCTCCTGAAAGAGAAGAAGGTGGAGATGCTGGTGGACCCGGACCTCCAGAGCGGCTTCGTGGAGCATGAGGTGGAGTCACTCATCCAGGTGGCTCTGCTCTGCACGCAGGGCTCCCCGATGGACCGGCCCAAGATGTCGGAGGTGGTGAGGATGCTGGAGGGCGATGGCCTCGCGGAGCGGTGGGAGGAGTGGCAGAAGGTGGAGGTGGTCCGGCAGGAGGCGGAGCTGGCCCCCCGCCACAACGACTGGATCGTCGACTCGACCTACAATCTCCGGGCAATGGAGCTGTCCGGCCCGAGGTAAAAGAAACGAAAGACAAAATCACAAAGCATCCAACCTTTGCTCGACGGCTTCCTCGCCCTTGTTTGTGTATATGACAGACAGATCGATAGCTGGCAAATCTGGAGGGAAAAATGGTTTACTTGTAACCCTCCCTGGTGCCTCGGTAATTTTCAAGTAGGCTCTGCACTTGGTTGTCGTTAGAAATGCATGGCCGGGCGGAATTGCAACACATTGTTGTGGCGGCTCTGCGTCTGTAATGGCTGAACAACTGATGCCTCTCTCTCTGCTGTATTGTACGTACAACTCTCTCTTTTGACGGTGCTAAACATCCTAGGCAATCTTTTTTGGTCTCCCGGGTCACACCGTGTCCGCCTGTACTTTGTTACTCTTCGTTGAAAAACTATACTGGTAGCAAACTCAACTCTTTATCTGAAAAAAA - >LOC_Os04g38480.2
GGTAAAAAAAAAAGGAGAGAGAGAGGAGAGACAGGTCGCTTCCTGCTTCCATTGGAGAAGAGGAGAGGAGAGGAGAGGAGACCGAGCCGGCGGCGGCGGCGACGAGGAGAGGGAGCTGATCGGGCGGTCCCCCCCTTTGCCGAGGGGACGCCGGCGGCCTCCGGGTTGGGTCCACTTGGCAGCGGTGAGCGGCGGCGGGGGATGGCGGAGGCGCGGCTGCTGCGGCGGCGGCGGCTGTGCTTGGCGGTGCCGTTCGTGTGGGTGGTGGCGGTGGCCGTGAGCCGGGTCGGCGCCAACACGGAGGGTGATGCCCTATATAGTCTGCGCCAAAGTCTGAAAGATGCTAACAATGTGCTGCAGAGTTGGGATCCCACTCTGGTCAATCCATGCACATGGTTCCATGTAACTTGTAACCCTGACAACAGCGTGATCAGAGTTGATCTTGGAAATGCACAACTGTCAGGTGCATTGGTTCCCCAGCTTGGGCAGTTGAAAAATCTGCAATATCTGGAGCTTTACAGCAACAACATAAGTGGGACAATACCTAATGAACTGGGAAACTTAACTAACTTGGTCAGTTTGGATCTTTACCTGAACAACTTCACTGGTTTTATTCCGGAAACCTTGGGGCAACTCTACAAGCTGCGTTTCCTTCGTCTTAACAACAACAGTCTTTCTGGTTCAATTCCAAAATCCTTGACCAATATCACTACTCTTCAAGTTCTGGATCTCTCAAATAACAATCTCTCAGGAGAGGTTCCGTCTACTGGCTCCTTTTCACTCTTTACCCCTATAAGTTTTGCTAATAATAAAGATCTTTGTGGCCCGGGTACTACAAAACCCTGCCCTGGAGCTCCACCTTTTTCTCCACCACCTCCTTTCAATCCCCCAACACCTACTGTGTCACAAGGTGACTCCAAAACTGGAGCAATTGCTGGAGGTGTTGCTGCAGCTGCTGCATTGCTGTTTGCGGTTCCGGCAATTGGATTTGCATGGTGGCGGCGGCGTAAACCTGAAGAACACTTCTTTGATGTCCCTGCTGAGGAGGATCCGGAAGTGCACCTTGGCCAACTTAAGAGATTCTCACTCCGGGAGCTTCAAGTTGCTACTGATAACTTTAGCAATAAGAATATTCTGGGAAGAGGTGGCTTTGGAAAGGTGTACAAAGGTAGACTGGCAGATGGCTCGTTGGTAGCAGTGAAAAGATTAAAAGAAGAACGTACCCCTGGTGGTGAGCTCCAGTTCCAAACAGAAGTTGAAATGATTAGCATGGCGGTGCATAGGAACCTGCTTCGGCTCCGTGGATTTTGCATGACGCCTACAGAACGGTTACTTGTCTATCCCTACATGGCTAATGGGAGTGTCGCATCACGATTGCGAGAGCGGCAGCCAAATGATCCGCCGCTTGAATGGCAAACAAGAACTCGGATTGCGCTGGGATCTGCCAGAGGATTGTCCTACTTGCACGACCATTGTGATCCCAAGATCATTCATCGTGATGTCAAAGCTGCAAATATTCTGTTGGATGAAGATTTTGAGGCAGTCGTGGGTGACTTTGGACTGGCCAAACTTATGGATTACAAGGACACTCATGTAACCACAGCTGTTCGTGGGACGATCGGACACATTGCTCCTGAGTACCTCTCTACTGGGAAGTCCTCTGAGAAGACTGATGTTTTTGGCTATGGAATCATGCTTCTTGAGCTCATTACAGGACAAAGGGCATTTGATCTTGCTCGTCTTGCAAACGATGATGATGTGATGTTGCTCGATTGGGTGAAAGGGCTCCTGAAAGAGAAGAAGGTGGAGATGCTGGTGGACCCGGACCTCCAGAGCGGCTTCGTGGAGCATGAGGTGGAGTCACTCATCCAGGTGGCTCTGCTCTGCACGCAGGGCTCCCCGATGGACCGGCCCAAGATGTCGGAGGTGGTGAGGATGCTGGAGGGCGATGGCCTCGCGGAGCGGTGGGAGGAGTGGCAGAAGGTGGAGGTGGTCCGGCAGGAGGCGGAGCTGGCCCCCCGCCACAACGACTGGATCGTCGACTCGACCTACAATCTCCGGGCAATGGAGCTGTCCGGCCCGAGGTAAAAGAAACGAAAGACAAAATCACAAAGCATCCAACCTTTGCTCGACGGCTTCCTCGCCCTTGTTTGTGTATATGACAGACAGATCGATAGCTGGCAAATCTGGAGGGAAAAATGGTTTACTTGTAACCCTCCCTGGTGCCTCGGTAATTTTCAAGTAGGCTCTGCACTTGGTTGTCGTTAGAAATGCATGGCCGGGCGGAATTGCAACACATTGTTGTGGCGGCTCTGCGTCTGTAATGGCTGAACAACTGATGCCTCTCTCTCTGCTGTATTGTACGTACAACTCTCTCTTTTGACGGTGCTAAACATCCTAGGCAATCTTTTTTGGTCTCCCGGGTCACACCGTGTCCGCCTGTACTTTGTTACTCTTCGTTGAAAAACTATACTGGTAGCAAACTCAACTCTTTATCTGAAAAAAA
CDS Sequence
- >LOC_Os04g38480.1
ATGGCGGAGGCGCGGCTGCTGCGGCGGCGGCGGCTGTGCTTGGCGGTGCCGTTCGTGTGGGTGGTGGCGGTGGCCGTGAGCCGGGTCGGCGCCAACACGGAGGGTGATGCCCTATATAGTCTGCGCCAAAGTCTGAAAGATGCTAACAATGTGCTGCAGAGTTGGGATCCCACTCTGGTCAATCCATGCACATGGTTCCATGTAACTTGTAACCCTGACAACAGCGTGATCAGAGTTGATCTTGGAAATGCACAACTGTCAGGTGCATTGGTTCCCCAGCTTGGGCAGTTGAAAAATCTGCAATATCTGGAGCTTTACAGCAACAACATAAGTGGGACAATACCTAATGAACTGGGAAACTTAACTAACTTGGTCAGTTTGGATCTTTACCTGAACAACTTCACTGGTTTTATTCCGGAAACCTTGGGGCAACTCTACAAGCTGCGTTTCCTTCGTCTTAACAACAACAGTCTTTCTGGTTCAATTCCAAAATCCTTGACCAATATCACTACTCTTCAAGTTCTGGATCTCTCAAATAACAATCTCTCAGGAGAGGTTCCGTCTACTGGCTCCTTTTCACTCTTTACCCCTATAAGTTTTGCTAATAATAAAGATCTTTGTGGCCCGGGTACTACAAAACCCTGCCCTGGAGCTCCACCTTTTTCTCCACCACCTCCTTTCAATCCCCCAACACCTACTGTGTCACAAGGTGACTCCAAAACTGGAGCAATTGCTGGAGGTGTTGCTGCAGCTGCTGCATTGCTGTTTGCGGTTCCGGCAATTGGATTTGCATGGTGGCGGCGGCGTAAACCTGAAGAACACTTCTTTGATGTCCCTGCTGAGGAGGATCCGGAAGTGCACCTTGGCCAACTTAAGAGATTCTCACTCCGGGAGCTTCAAGTTGCTACTGATAACTTTAGCAATAAGAATATTCTGGGAAGAGGTGGCTTTGGAAAGGTGTACAAAGGTAGACTGGCAGATGGCTCGTTGGTAGCAGTGAAAAGATTAAAAGAAGAACGTACCCCTGGTGGTGAGCTCCAGTTCCAAACAGAAGTTGAAATGATTAGCATGGCGGTGCATAGGAACCTGCTTCGGCTCCGTGGATTTTGCATGACGCCTACAGAACGGTTACTTGTCTATCCCTACATGGCTAATGGGAGTGTCGCATCACGATTGCGAGAGCGGCAGCCAAATGATCCGCCGCTTGAATGGCAAACAAGAACTCGGATTGCGCTGGGATCTGCCAGAGGATTGTCCTACTTGCACGACCATTGTGATCCCAAGATCATTCATCGTGATGTCAAAGCTGCAAATATTCTGTTGGATGAAGATTTTGAGGCAGTCGTGGGTGACTTTGGACTGGCCAAACTTATGGATTACAAGGACACTCATGTAACCACAGCTGTTCGTGGGACGATCGGACACATTGCTCCTGAGTACCTCTCTACTGGGAAGTCCTCTGAGAAGACTGATGTTTTTGGCTATGGAATCATGCTTCTTGAGCTCATTACAGGACAAAGGGCATTTGATCTTGCTCGTCTTGCAAACGATGATGATGTGATGTTGCTCGATTGGGTGAAAGGGCTCCTGAAAGAGAAGAAGGTGGAGATGCTGGTGGACCCGGACCTCCAGAGCGGCTTCGTGGAGCATGAGGTGGAGTCACTCATCCAGGTGGCTCTGCTCTGCACGCAGGGCTCCCCGATGGACCGGCCCAAGATGTCGGAGGTGGTGAGGATGCTGGAGGGCGATGGCCTCGCGGAGCGGTGGGAGGAGTGGCAGAAGGTGGAGGTGGTCCGGCAGGAGGCGGAGCTGGCCCCCCGCCACAACGACTGGATCGTCGACTCGACCTACAATCTCCGGGCAATGGAGCTGTCCGGCCCGAGGTAA - >LOC_Os04g38480.2
ATGGCGGAGGCGCGGCTGCTGCGGCGGCGGCGGCTGTGCTTGGCGGTGCCGTTCGTGTGGGTGGTGGCGGTGGCCGTGAGCCGGGTCGGCGCCAACACGGAGGGTGATGCCCTATATAGTCTGCGCCAAAGTCTGAAAGATGCTAACAATGTGCTGCAGAGTTGGGATCCCACTCTGGTCAATCCATGCACATGGTTCCATGTAACTTGTAACCCTGACAACAGCGTGATCAGAGTTGATCTTGGAAATGCACAACTGTCAGGTGCATTGGTTCCCCAGCTTGGGCAGTTGAAAAATCTGCAATATCTGGAGCTTTACAGCAACAACATAAGTGGGACAATACCTAATGAACTGGGAAACTTAACTAACTTGGTCAGTTTGGATCTTTACCTGAACAACTTCACTGGTTTTATTCCGGAAACCTTGGGGCAACTCTACAAGCTGCGTTTCCTTCGTCTTAACAACAACAGTCTTTCTGGTTCAATTCCAAAATCCTTGACCAATATCACTACTCTTCAAGTTCTGGATCTCTCAAATAACAATCTCTCAGGAGAGGTTCCGTCTACTGGCTCCTTTTCACTCTTTACCCCTATAAGTTTTGCTAATAATAAAGATCTTTGTGGCCCGGGTACTACAAAACCCTGCCCTGGAGCTCCACCTTTTTCTCCACCACCTCCTTTCAATCCCCCAACACCTACTGTGTCACAAGGTGACTCCAAAACTGGAGCAATTGCTGGAGGTGTTGCTGCAGCTGCTGCATTGCTGTTTGCGGTTCCGGCAATTGGATTTGCATGGTGGCGGCGGCGTAAACCTGAAGAACACTTCTTTGATGTCCCTGCTGAGGAGGATCCGGAAGTGCACCTTGGCCAACTTAAGAGATTCTCACTCCGGGAGCTTCAAGTTGCTACTGATAACTTTAGCAATAAGAATATTCTGGGAAGAGGTGGCTTTGGAAAGGTGTACAAAGGTAGACTGGCAGATGGCTCGTTGGTAGCAGTGAAAAGATTAAAAGAAGAACGTACCCCTGGTGGTGAGCTCCAGTTCCAAACAGAAGTTGAAATGATTAGCATGGCGGTGCATAGGAACCTGCTTCGGCTCCGTGGATTTTGCATGACGCCTACAGAACGGTTACTTGTCTATCCCTACATGGCTAATGGGAGTGTCGCATCACGATTGCGAGAGCGGCAGCCAAATGATCCGCCGCTTGAATGGCAAACAAGAACTCGGATTGCGCTGGGATCTGCCAGAGGATTGTCCTACTTGCACGACCATTGTGATCCCAAGATCATTCATCGTGATGTCAAAGCTGCAAATATTCTGTTGGATGAAGATTTTGAGGCAGTCGTGGGTGACTTTGGACTGGCCAAACTTATGGATTACAAGGACACTCATGTAACCACAGCTGTTCGTGGGACGATCGGACACATTGCTCCTGAGTACCTCTCTACTGGGAAGTCCTCTGAGAAGACTGATGTTTTTGGCTATGGAATCATGCTTCTTGAGCTCATTACAGGACAAAGGGCATTTGATCTTGCTCGTCTTGCAAACGATGATGATGTGATGTTGCTCGATTGGGTGAAAGGGCTCCTGAAAGAGAAGAAGGTGGAGATGCTGGTGGACCCGGACCTCCAGAGCGGCTTCGTGGAGCATGAGGTGGAGTCACTCATCCAGGTGGCTCTGCTCTGCACGCAGGGCTCCCCGATGGACCGGCCCAAGATGTCGGAGGTGGTGAGGATGCTGGAGGGCGATGGCCTCGCGGAGCGGTGGGAGGAGTGGCAGAAGGTGGAGGTGGTCCGGCAGGAGGCGGAGCTGGCCCCCCGCCACAACGACTGGATCGTCGACTCGACCTACAATCTCCGGGCAATGGAGCTGTCCGGCCCGAGGTAA
Protein Sequence
- >LOC_Os04g38480.1
MAEARLLRRRRLCLAVPFVWVVAVAVSRVGANTEGDALYSLRQSLKDANNVLQSWDPTLVNPCTWFHVTCNPDNSVIRVDLGNAQLSGALVPQLGQLKNLQYLELYSNNISGTIPNELGNLTNLVSLDLYLNNFTGFIPETLGQLYKLRFLRLNNNSLSGSIPKSLTNITTLQVLDLSNNNLSGEVPSTGSFSLFTPISFANNKDLCGPGTTKPCPGAPPFSPPPPFNPPTPTVSQGDSKTGAIAGGVAAAAALLFAVPAIGFAWWRRRKPEEHFFDVPAEEDPEVHLGQLKRFSLRELQVATDNFSNKNILGRGGFGKVYKGRLADGSLVAVKRLKEERTPGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASRLRERQPNDPPLEWQTRTRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEDFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGIMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKVEMLVDPDLQSGFVEHEVESLIQVALLCTQGSPMDRPKMSEVVRMLEGDGLAERWEEWQKVEVVRQEAELAPRHNDWIVDSTYNLRAMELSGPR* - >LOC_Os04g38480.2
MAEARLLRRRRLCLAVPFVWVVAVAVSRVGANTEGDALYSLRQSLKDANNVLQSWDPTLVNPCTWFHVTCNPDNSVIRVDLGNAQLSGALVPQLGQLKNLQYLELYSNNISGTIPNELGNLTNLVSLDLYLNNFTGFIPETLGQLYKLRFLRLNNNSLSGSIPKSLTNITTLQVLDLSNNNLSGEVPSTGSFSLFTPISFANNKDLCGPGTTKPCPGAPPFSPPPPFNPPTPTVSQGDSKTGAIAGGVAAAAALLFAVPAIGFAWWRRRKPEEHFFDVPAEEDPEVHLGQLKRFSLRELQVATDNFSNKNILGRGGFGKVYKGRLADGSLVAVKRLKEERTPGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASRLRERQPNDPPLEWQTRTRIALGSARGLSYLHDHCDPKIIHRDVKAANILLDEDFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGIMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKEKKVEMLVDPDLQSGFVEHEVESLIQVALLCTQGSPMDRPKMSEVVRMLEGDGLAERWEEWQKVEVVRQEAELAPRHNDWIVDSTYNLRAMELSGPR*