Information report for BSR-D1;ZFP36
Gene Details
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Functional Descriptions
- This allele causes a single nucleotide change in the promoter of the BSR-D1 gene, which results in reduced expression of the gene through the binding of the repressive MYB transcription factor and, consequently, an inhibition of H2O2 degradation and enhanced disease resistance.
- The ascorbate peroxidase APX1 is a direct target of a zinc finger transcription factor ZFP36 and a late embryogenesis abundant protein OsLEA5 interacts with ZFP36 to co-regulate OsAPX1 in seed germination in rice.
- The seed germination is highly inhibited in ZFP36 overexpression plants under ABA treatment, while an RNA interference (RNAi) mutant of OsLEA5 rice seeds were less sensitive to ABA, and exogenous ASC (ascorbate acid) could alleviate the inhibition induced by ABA.
- Thus, our conclusion is that OsAPX1 is a direct target of ZFP36 and OsLEA5 could interact with ZFP36 to co-regulate ABA-inhibited seed germination by controlling the expression of OsAPX1.
- oryzae-induced expression of BSR-D1 RNA and degradation of hydrogen peroxide to achieve resistance to M.
- However, the global effect of biological process and molecular function on blast resistance mediated by BSR-D1 remains unknown.
- Furthermore, we identified a novel peroxidase-encoding gene, Perox3, as a new BSR-D1 target gene that reduces resistance to M.
- We further found that BSR-D1 indirectly regulates salicylic acid biosynthesis, metabolism, and signal transduction downstream of the activation of H2 O2 signalling in the BSR-D1-mediated immune response.
Functional Keywords
Literature and News
- A Natural Allele of a Transcription Factor in Rice Confers Broad-Spectrum Blast Resistance . DOI: 10.1016/j.cell.2017.06.008 ; PMID: 28666113
- The ascorbate peroxidase APX1 is a direct target of a zinc finger transcription factor ZFP36 and a late embryogenesis abundant protein OsLEA5 interacts with ZFP36 to co-regulate OsAPX1 in seed germination in rice . DOI: 10.1016/j.bbrc.2017.10.128 ; PMID: 29106954
- New insights into bsr-d1-mediated broad-spectrum resistance to rice blast . DOI: 10.1111/mpp.12941 ; PMID: 32394633
Gene Resources
- UniProt: Q75KE5
- EMBL: AC106887, AC147803, AK059839
- AlphaFoldDB: Q75KE5
- EnsemblPlants: Os03t0437200-01
- Gramene: Os03t0437200-01
- KEGG: dosa:Os03g0437200, osa:4333197
- Orthologous matrix: PESYAGM
Homologs
- Hordeum vulgare: MLOC_70662.1
- Panicum virgatum: Pavir.9NG503800.1.p
- Setaria italica: Seita.9G357400.1.p
- Setaria viridis: Sevir.9G363500.1.p
- Zea mays: GRMZM2G106026_P01, GRMZM2G069176_P01, GRMZM2G113860_P01
Sequences
cDNA Sequence
- >LOC_Os03g32230.1
GCTCATCATCCATCCATCTCCCTGCAGCTACGTACTGTACTTGTTAGCAATCAATCCCATCAAATCATCCACCGCTCGCTGCTGCTGCTACGTACTATACAGCTTGATTAATTAGGTTTTACGACGACGGCAACGGGGACAGATATGACGGCCGCCCTGCAAGCGCTGCTCGACCCGACGGCGCTGTCCTTGGGCCTGCCCACGCCGGCGATCAACAAGGAGGAGTACCTCGCCATCTGCCTCGCCGCGCTCGCCTGCACGCGGGCGGGGAAGGCCCTGGTGGGAGTGGGAGGCCAGCAGCAGGTGCAGGCCTGCAATAAGTGGCTGTGCCCAGCGCCCGCGGCGCCTGAGGAGCTCCGCTTCCGGTGCACCGTCTGCGGGAAGGCCTTCGCCTCGTACCAGGCGCTCGGCGGACACAAGTCCAGCCACCGGAAGCCGCCTTCCCCGGGAGACCACTACGGCGCCGCCGCCGCGGCGCAGCAGCTGGCATCCGCTGGTGACTCGAAGGAGGACTCGGCGTCGTCAGCGGCCGGGAGCACTGGCCCGCACCGGTGCACCATCTGCAGGAGGAGCTTCGCGACGGGGCAGGCGCTCGGCGGCCACAAGCGCTGCCACTACTGGGACGGCACGTCGGTGTCCGTCTCCGTCTCGGCGTCCGCGTCGGCCGCCTCGTCGGCCGTCAGGAACTTCGACCTCAACCTGATGCCGCTGCCGGAGAGCACAGCCGCCGCCGGGATCAAGAGGTGGGCGGAGGAGGAGGAGGTGCAGAGTCCACTGCCGGTCAAGAAGCTCAGGATGTCCAACTAATTCATCATACGCCATCTTGTAAAAACAAGAGATCTGCCCATTGATCGACTCTATTGAACAGAGTCTATTCTTTGATTTTTTTTTTCTTTTCAACTCACTAATTGTTTGGTTTCTGTCATCGAGTATGCAACAAGCTAAGCTGGTGACCATGGATCTTCCAAGATTGATTGTCGCCAAGGGACATATATGGTTCTAGGAGTGTTGATTCATTTGATTCTTTGTATATTTGTTCAATCTAAAAATTAATGTACTCAATCTGCTCAATATATATAGACGCTATATTATTACGACTCCA
CDS Sequence
- >LOC_Os03g32230.1
ATGACGGCCGCCCTGCAAGCGCTGCTCGACCCGACGGCGCTGTCCTTGGGCCTGCCCACGCCGGCGATCAACAAGGAGGAGTACCTCGCCATCTGCCTCGCCGCGCTCGCCTGCACGCGGGCGGGGAAGGCCCTGGTGGGAGTGGGAGGCCAGCAGCAGGTGCAGGCCTGCAATAAGTGGCTGTGCCCAGCGCCCGCGGCGCCTGAGGAGCTCCGCTTCCGGTGCACCGTCTGCGGGAAGGCCTTCGCCTCGTACCAGGCGCTCGGCGGACACAAGTCCAGCCACCGGAAGCCGCCTTCCCCGGGAGACCACTACGGCGCCGCCGCCGCGGCGCAGCAGCTGGCATCCGCTGGTGACTCGAAGGAGGACTCGGCGTCGTCAGCGGCCGGGAGCACTGGCCCGCACCGGTGCACCATCTGCAGGAGGAGCTTCGCGACGGGGCAGGCGCTCGGCGGCCACAAGCGCTGCCACTACTGGGACGGCACGTCGGTGTCCGTCTCCGTCTCGGCGTCCGCGTCGGCCGCCTCGTCGGCCGTCAGGAACTTCGACCTCAACCTGATGCCGCTGCCGGAGAGCACAGCCGCCGCCGGGATCAAGAGGTGGGCGGAGGAGGAGGAGGTGCAGAGTCCACTGCCGGTCAAGAAGCTCAGGATGTCCAACTAA
Protein Sequence
- >LOC_Os03g32230.1
MTAALQALLDPTALSLGLPTPAINKEEYLAICLAALACTRAGKALVGVGGQQQVQACNKWLCPAPAAPEELRFRCTVCGKAFASYQALGGHKSSHRKPPSPGDHYGAAAAAQQLASAGDSKEDSASSAAGSTGPHRCTICRRSFATGQALGGHKRCHYWDGTSVSVSVSASASAASSAVRNFDLNLMPLPESTAAAGIKRWAEEEEVQSPLPVKKLRMSN*