Gene Details:

• MSU gene ID: LOC_Os03g02010
• RAPdb gene ID: Os03g0110800
• Gene Symbol: OsDRM2
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• Whereas Arabidopsis drm1 drm2 double mutants showed no morphological alterations, targeted disruptants of rice OsDRM2 displayed pleiotropic developmental phenotypes in both vegetative and reproductive stages, including growth defects, semi-dwarfed stature, reductions in tiller number, delayed heading or no heading, abnormal panicle and spikelet morphology, and complete sterility.
• Our results suggest that OsDRM2 is responsible for de novo, CG and non-CG methylation in rice genomic sequences, and that DNA methylation regulated by OsDRM2 is essential for proper rice development in both vegetative and reproductive stages.
• Impaired growth and abnormal DNA methylation of OsDRM2 disruptants were restored by the complementation of wild-type OsDRM2 cDNA.
• Targeted disruption of an orthologue of DOMAINS REARRANGED METHYLASE 2, OsDRM2, impairs the growth of rice plants by abnormal DNA methylation.

Function-related keywords:

• dwarf ,  spikelet ,  tiller ,  reproductive ,  sterility ,  growth ,  vegetative ,  panicle ,  tiller-number

Literature:

• Functional characterization of a rice de novo DNA methyltransferase, OsDRM2, expressed in Escherichia coli and yeast .  DOI:  10.1016/j.bbrc.2013.01.067 ;  PMID:  23357425
• De novo methyltransferase, OsDRM2, interacts with the ATP-dependent RNA helicase, OseIF4A, in rice .  DOI:  10.1016/j.jmb.2013.05.021 ;  PMID:  23732981
• Targeted disruption of an orthologue of DOMAINS REARRANGED METHYLASE 2, OsDRM2, impairs the growth of rice plants by abnormal DNA methylation .  DOI:  10.1111/j.1365-313X.2012.04974.x ;  PMID:  22380881
• The ortholog of DDM1 is mainly required for CHG and CG methylation of heterochromatin and is involved in DRM2-mediated CHH methylation that targets mostly genic regions of the rice genome .  DOI:  10.1104/pp.16.00393 ;  PMID:  27208249

Related News:

Gene Resources:

• NCBI ID: AK065147
• UniProt accessions:

Sequences: