Gene Details:

• MSU gene ID: LOC_Os03g01222
• RAPdb gene ID: Os03g0102100
• Gene Symbol: HPA1
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• In a further feeding assay with exogenous glutathione (GSH), a non-enzymatic antioxidant that consumes H2O2, the H2O2 accumulation and leaf senescence phenotypes of HPA1 were obviously compensated.
• Taken together, our findings suggest that the accumulation of H2O2 in HPA1 may be mediated by an altered folate status and redox homeostasis, subsequently triggering leaf senescence.
• Proteomics and enzyme activity analyses further revealed that mitochondria oxidative phosphorylation complex I and complex V were differentially expressed in HPA1, which was consistent with the H2O2 accumulation in HPA1.
• Map-based cloning revealed that HPA1 encodes a tetrahydrofolate deformylase, and its deficiency led to the accumulation of tetrahydrofolate, 5-formyl tetrahydrofolate and 10-formyl tetrahydrofolate, in contrast, a decrease in 5,10-methenyl-tetrahydrofolate.

Function-related keywords:

• leaf ,  leaf-senescence ,  senescence ,  mitochondria ,  map-based-cloning ,  oxidative ,  redox-homeostasis

Literature:

• Formyl tetrahydrofolate deformylase affects hydrogen peroxide accumulation and leaf senescence by regulating the folate status and redox homeostasis in rice .  DOI:  10.1007/s11427-020-1773-7 ;  PMID:  32949368

Related News:

Gene Resources:

• NCBI ID:
• UniProt accessions:

Sequences: