Information report for ARF8
Gene Details
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Functional Descriptions
- It was also shown that expression of OsGH3-2, an rice IAA-conjugating enzyme, was positively regulated by ARF8.
- MicroRNA167 (miR167) was shown to cleave auxin responsive factor 8 (ARF8) mRNA in cultured rice cells.
- When cells grew in auxin-free medium, miR167 level decreased, resulting in an increase in the level of ARF8 mRNA.
- This study provides an evidence in which the exogeneous auxin signal is transduced to OsGH3-2 through miR167 and ARF8 in sequence.
- This proposed auxin signal transduction pathway, auxin-miR167-ARF8-OsGH3-2, could be, in conjunction with the other microRNA-mediated auxin signals, an important one for responding to exogeneous auxin and for determining the cellular free auxin level which guides appropriate auxin responses.
- ‘Evidence of an auxin signal pathway, microRNA167-ARF8-GH3, and its response to exogenous auxin in cultured rice cells’.
- Mutation of WRKY45 compromises the enhanced blast resistance and bacterial leaf blight resistance conferred by ARF8 mutant.
- miR160a enhances disease resistance partially by suppressing ARF8, as mutation of ARF8 in MIM160 background partially restores the compromised resistance resulting from MIM160.
- ARF8 protein binds directly to the promoter and suppresses the expression of WRKY45, which acts as a positive regulator of rice immunity.
Functional Keywords
- iaa , auxin , leaf , resistance , disease , disease-resistance , blight , blast , immunity , blast-resistance
Literature and News
Gene Resources
- UniProt: Q6K223
- EMBL: AK243230, AP006168, AP008208
- AlphaFoldDB: Q6K223
- EnsemblPlants: Os02t0628600-01
- Gramene: Os02t0628600-01
- KEGG: dosa:Os02g0628600
- Orthologous matrix: HGVAWNF
- InterPro: IPR003340, IPR010525, IPR015300
- PANTHER: PTHR31384, PTHR31384:SF37
- SUPFAM: SSF101936
- PROSITE: PS50863, PS51745
- Gene3D: 2.30.30.1040, 2.40.330.10, 3.10.20.90
- OrthoDB: Q6K223
- SWISS-MODEL: Q6K223
- Conserved Domain Database: cd10017
- eggNOG: ENOG502QQ5I
Homologs
- Brachypodium distachyon: Bradi3g49320.1.p
- Hordeum vulgare: MLOC_77438.2
- Panicum virgatum: Pavir.1KG387700.1.p
- Setaria italica: Seita.1G241500.1.p
- Setaria viridis: Sevir.1G246300.1.p
- Zea mays: GRMZM2G081406_P01
Sequences
cDNA Sequence
- >LOC_Os02g41800.1
GCGTGTTACCGTGGGAACGGCAGCCAAAAGCCACCACCACCAACCTCTCGTCTTCGCCTCCTCTCCCACCCCCTCACGACGAACACTCACACGGTCACACCACTACCCCTGCGAGATCGGTTGCTGGCGCTGCTGCTGGTGGTGGGTGCGTGGCGATGATCACGTTCGCGGACCTGGCGGAGCCGGCGCCCGGCGCCGAGCGGTGCGTCGACCGGCAGCTGTGGCTGGCGTGCGCGGGGGGCATGTGCACCGTGCCGCCGGTGGGCGCCGCCGTGTACTACTTCCCGCAGGGGCACGCCGAGCACGCGCTCGGCCTCGCCGCGCCGGAGCTCTCCGCGGCGCGCGTCCCGGCGCTCGTGCCCTGCCGCGTCGCGTCCGTGCGGTACATGGCCGACCCGGACACCGACGAGGTGTTCGCCAGGATCCGCCTCGTGCCGCTCCGCGCCGCGGAGGATGGGGACGTCGAGGAGGATGGCGCCGCGGCAGGCGAGGAGCACGAGAAGCCGGCGTCGTTCGCCAAGACGCTGACGCAGTCGGATGCCAACAACGGCGGGGGGTTCTCGGTGCCCAGGTACTGCGCCGAGACCATCTTCCCGCGCCTGGACTACGCCGCCGACCCGCCCGTGCAGACCGTCGTCGCCAAGGACGTCCATGGAGTCGCCTGGAACTTCCGCCACATCTACAGGGGCACGCCGCGCCGGCACCTGCTCACCACGGGGTGGAGCACGTTCGTGAACCAGAAGAAGCTCGTGGCCGGCGACTCCATCGTGTTCCTCCGCGGCGACGGAGGGGACCTGCACGTCGGCATCCGGCGCGCCAAGCGCGGGTTTTGCGGCGGCGGAGGCGGAGCCGAGGAGGCCTCCCTGCCCGGGTGGGACCAGTACGGCGGCCTGATGCGAGGCAATGCGAGCCCGTGCGCGGCCGCCAAGGGGCGGGGCAAGGTGCGCGCGGAGGACCTCGTCGAGGCGGCGAGGCTGGCGAACGGCGGGCAGCCGTTCGAGGTCGTGTACTACCCGCGCGCCAGCACGCCGGAGTTCTGCGTGCGCGCGGCGGCGGTCCGCGCGGCGATGCGGGTGCAGTGGTGCCCCGGGATGCGGTTCAAGATGGCGTTCGAGACCGAGGACTCCTCCCGGATCAGCTGGTTCATGGGCACCGTCGCCAGCGTCCAGGTCGCCGACCCCATCCGTTGGCCGCAGTCGCCGTGGCGGCTTCTCCAGGTGACCTGGGACGAACCGGACCTCCTCCAGAACGTGAAGCGGGTGAGCCCATGGTTGGTCGAGCTGGTGTCGAGCATGCCGGCCATCAACCTCTCGTCTTTCTCGCCGCCGCGCAAGAAGCCCCGGATTCTGGCGTACCCGGAGTTCCCCTTCGAGGGGCAGCTCCTCAACCCGGCGTTCCCGCCAAACCCGCTGGCACACGGCCACCACCATTACCATCACAACCACCCGTCCTTCTTCCCGTTCCCCGACGTTAGTGCTCCTGCAGGCATACAGGGAGCCAGGCATGCGCAATTTGGTCCATCTTTATCAGATCTCCACCTTACCCACCTGCAGTCGAGCCTCATGTACCCGGGGCTCCGCCGCCCCGATCATGTCGGTCCAACATCCATCCCGCCACCAAGAATCAGCACTGACCTGACAATGGGCAGCTCGCCGCCGGCGCGCGCTCTGTCCATGGGCGCCAAGAAGCCCGACGACGCCAAGCCGCCGGGGCTAATGCTGTTCGGGCAGAGGATACTGACCGAGCGCCAGATGAGCCTTAGCGGCACCACCTCGCCGGCGGCCACCGGGAACAGCTCTCTCAACTGGAACACCGAGAAAGGTGCCTCGGAGGGCTCGGGCTCCGGCGTCATCCAGAACAGCCCCACCGACAACACGTCGTCGGAGAGGCTCCAGTGGTTCAGGGAGAACAGCACCGTCTCCGAGCTCGGGCTGGAGCCCGGGCAGTGCAAGGTGTTCATCGAGTCCGACACGGTCGGCCGCAACCTCGACCTCTCGTCGCTGGCCTCGTTCGAGCAGCTCTACGGCCGGCTGTCCGAGATGTTCTGCATCGACAGCGCGGAGCTGAGGAGCCGTGTGCTCTACCGTGGCGCCACCGGCGAAGTGAGGCACGCCGGCGACGAGCCATTCAGCGAGTTCATTAAGTTGGCGAGGAGGCTTACCATACTAACCGACGCCGGGAGCGACAACTTAGGGAGCTAGAGAGCAAAGAGGACAACCGGGAGCATCGCCGTAGTATGTACAGCTTGAATGAGCTTATGATTTTGTATCAACTAGTAGCAGTAGTAGCAGCACTAGTAATTTCCGTTCAACTAGTAATGTCCCCAACTCTGCAGTAGAGATTTCAACAAGAAAGCTCAATCTGCACAGGTATCCTACTGTTCTCCTGTATCCTTCTTCATCATCATCAACAACGATCAGCTGCGTGTACTTGTTGATTCC - >LOC_Os02g41800.2
GCGTGTTACCGTGGGAACGGCAGCCAAAAGCCACCACCACCAACCTCTCGTCTTCGCCTCCTCTCCCACCCCCTCACGACGAACACTCACACGGTCACACCACTACCCCTGCGAGATCGGTTGCTGGCGCTGCTGCTGGTGGTGGGTGCGTGGCGATGATCACGTTCGCGGACCTGGCGGAGCCGGCGCCCGGCGCCGAGCGGTGCGTCGACCGGCAGCTGTGGCTGGCGTGCGCGGGGGGCATGTGCACCGTGCCGCCGGTGGGCGCCGCCGTGTACTACTTCCCGCAGGGGCACGCCGAGCACGCGCTCGGCCTCGCCGCGCCGGAGCTCTCCGCGGCGCGCGTCCCGGCGCTCGTGCCCTGCCGCGTCGCGTCCGTGCGGTACATGGCCGACCCGGACACCGACGAGGTGTTCGCCAGGATCCGCCTCGTGCCGCTCCGCGCCGCGGAGGATGGGGACGTCGAGGAGGATGGCGCCGCGGCAGGCGAGGAGCACGAGAAGCCGGCGTCGTTCGCCAAGACGCTGACGCAGTCGGATGCCAACAACGGCGGGGGGTTCTCGGTGCCCAGGTACTGCGCCGAGACCATCTTCCCGCGCCTGGACTACGCCGCCGACCCGCCCGTGCAGACCGTCGTCGCCAAGGACGTCCATGGAGTCGCCTGGAACTTCCGCCACATCTACAGGGGCACGCCGCGCCGGCACCTGCTCACCACGGGGTGGAGCACGTTCGTGAACCAGAAGAAGCTCGTGGCCGGCGACTCCATCGTGTTCCTCCGCGGCGACGGAGGGGACCTGCACGTCGGCATCCGGCGCGCCAAGCGCGGGTTTTGCGGCGGCGGAGGCGGAGCCGAGGAGGCCTCCCTGCCCGGGTGGGACCAGTACGGCGGCCTGATGCGAGGCAATGCGAGCCCGTGCGCGGCCGCCAAGGGGCGGGGCAAGGTGCGCGCGGAGGACCTCGTCGAGGCGGCGAGGCTGGCGAACGGCGGGCAGCCGTTCGAGGTCGTGTACTACCCGCGCGCCAGCACGCCGGAGTTCTGCGTGCGCGCGGCGGCGGTCCGCGCGGCGATGCGGGTGCAGTGGTGCCCCGGGATGCGGTTCAAGATGGCGTTCGAGACCGAGGACTCCTCCCGGATCAGCTGGTTCATGGGCACCGTCGCCAGCGTCCAGGTCGCCGACCCCATCCGTTGGCCGCAGTCGCCGTGGCGGCTTCTCCAGGTGACCTGGGACGAACCGGACCTCCTCCAGAACGTGAAGCGGGTGAGCCCATGGTTGGTCGAGCTGGTGTCGAGCATGCCGGCCATCAACCTCTCGTCTTTCTCGCCGCCGCGCAAGAAGCCCCGGATTCTGGCGTACCCGGAGTTCCCCTTCGAGGGGCAGCTCCTCAACCCGGCGTTCCCGCCAAACCCGCTGGCACACGGCCACCACCATTACCATCACAACCACCCGTCCTTCTTCCCGTTCCCCGACGTTAGTGCTCCTGCAGGCATACAGGGAGCCAGGCATGCGCAATTTGGTCCATCTTTATCAGATCTCCACCTTACCCACCTGCAGTCGAGCCTCATGTACCCGGGGCTCCGCCGCCCCGATCATGTCGGTCCAACATCCATCCCGCCACCAAGAATCAGCACTGACCTGACAATGGGCAGCTCGCCGCCGGCGCGCGCTCTGTCCATGGGCGCCAAGAAGCCCGACGACGCCAAGCCGCCGGGGCTAATGCTGTTCGGGCAGAGGATACTGACCGAGCGCCAGATGAGCCTTAGCGGCACCACCTCGCCGGCGGCCACCGGGAACAGCTCTCTCAACTGGAACACCGAGAAAGGTGCCTCGGAGGGCTCGGGCTCCGGCGTCATCCAGAACAGCCCCACCGACAACACGTCGTCGGAGAGGCTCCAGTGGTTCAGGGAGAACAGCACCGTCTCCGAGCTCGGGCTGGAGCCCGGGCAGTGCAAGGTGTTCATCGAGTCCGACACGGTCGGCCGCAACCTCGACCTCTCGTCGCTGGCCTCGTTCGAGCAGCTCTACGGCCGGCTGTCCGAGATGTTCTGCATCGACAGCGCGGAGCTGAGGAGCCGTGTGCTCTACCGTGGCGCCACCGGCGAAGTGAGGCACGCCGGCGACGAGCCATTCAGCGAGTTCATTAAGTTGGCGAGGAGGCTTACCATACTAACCGACGCCGGGAGCGACAACTTAGGGAGCTAGAGAGCAAAGAGGACAACCGGGAGCATCGCCGTAGTATGTACAGCTTGAATGAGCTTATGATTTTGTATCAACTAGTAGCAGTAGTAGCAGCACTAGTAATTTCCGTTCAACTAGTAATGTCCCCAACTCTGCAGTAGAGATTTCAACAAGAAAGCTCAATCTGCACAGGTATCCTACTGTTCTCCTGTATCCTTCTTCATCATCATCAACAACGATCAGCTGCGTGTACTTGTTGATTCC
CDS Sequence
- >LOC_Os02g41800.1
ATGATCACGTTCGCGGACCTGGCGGAGCCGGCGCCCGGCGCCGAGCGGTGCGTCGACCGGCAGCTGTGGCTGGCGTGCGCGGGGGGCATGTGCACCGTGCCGCCGGTGGGCGCCGCCGTGTACTACTTCCCGCAGGGGCACGCCGAGCACGCGCTCGGCCTCGCCGCGCCGGAGCTCTCCGCGGCGCGCGTCCCGGCGCTCGTGCCCTGCCGCGTCGCGTCCGTGCGGTACATGGCCGACCCGGACACCGACGAGGTGTTCGCCAGGATCCGCCTCGTGCCGCTCCGCGCCGCGGAGGATGGGGACGTCGAGGAGGATGGCGCCGCGGCAGGCGAGGAGCACGAGAAGCCGGCGTCGTTCGCCAAGACGCTGACGCAGTCGGATGCCAACAACGGCGGGGGGTTCTCGGTGCCCAGGTACTGCGCCGAGACCATCTTCCCGCGCCTGGACTACGCCGCCGACCCGCCCGTGCAGACCGTCGTCGCCAAGGACGTCCATGGAGTCGCCTGGAACTTCCGCCACATCTACAGGGGCACGCCGCGCCGGCACCTGCTCACCACGGGGTGGAGCACGTTCGTGAACCAGAAGAAGCTCGTGGCCGGCGACTCCATCGTGTTCCTCCGCGGCGACGGAGGGGACCTGCACGTCGGCATCCGGCGCGCCAAGCGCGGGTTTTGCGGCGGCGGAGGCGGAGCCGAGGAGGCCTCCCTGCCCGGGTGGGACCAGTACGGCGGCCTGATGCGAGGCAATGCGAGCCCGTGCGCGGCCGCCAAGGGGCGGGGCAAGGTGCGCGCGGAGGACCTCGTCGAGGCGGCGAGGCTGGCGAACGGCGGGCAGCCGTTCGAGGTCGTGTACTACCCGCGCGCCAGCACGCCGGAGTTCTGCGTGCGCGCGGCGGCGGTCCGCGCGGCGATGCGGGTGCAGTGGTGCCCCGGGATGCGGTTCAAGATGGCGTTCGAGACCGAGGACTCCTCCCGGATCAGCTGGTTCATGGGCACCGTCGCCAGCGTCCAGGTCGCCGACCCCATCCGTTGGCCGCAGTCGCCGTGGCGGCTTCTCCAGGTGACCTGGGACGAACCGGACCTCCTCCAGAACGTGAAGCGGGTGAGCCCATGGTTGGTCGAGCTGGTGTCGAGCATGCCGGCCATCAACCTCTCGTCTTTCTCGCCGCCGCGCAAGAAGCCCCGGATTCTGGCGTACCCGGAGTTCCCCTTCGAGGGGCAGCTCCTCAACCCGGCGTTCCCGCCAAACCCGCTGGCACACGGCCACCACCATTACCATCACAACCACCCGTCCTTCTTCCCGTTCCCCGACGTTAGTGCTCCTGCAGGCATACAGGGAGCCAGGCATGCGCAATTTGGTCCATCTTTATCAGATCTCCACCTTACCCACCTGCAGTCGAGCCTCATGTACCCGGGGCTCCGCCGCCCCGATCATGTCGGTCCAACATCCATCCCGCCACCAAGAATCAGCACTGACCTGACAATGGGCAGCTCGCCGCCGGCGCGCGCTCTGTCCATGGGCGCCAAGAAGCCCGACGACGCCAAGCCGCCGGGGCTAATGCTGTTCGGGCAGAGGATACTGACCGAGCGCCAGATGAGCCTTAGCGGCACCACCTCGCCGGCGGCCACCGGGAACAGCTCTCTCAACTGGAACACCGAGAAAGGTGCCTCGGAGGGCTCGGGCTCCGGCGTCATCCAGAACAGCCCCACCGACAACACGTCGTCGGAGAGGCTCCAGTGGTTCAGGGAGAACAGCACCGTCTCCGAGCTCGGGCTGGAGCCCGGGCAGTGCAAGGTGTTCATCGAGTCCGACACGGTCGGCCGCAACCTCGACCTCTCGTCGCTGGCCTCGTTCGAGCAGCTCTACGGCCGGCTGTCCGAGATGTTCTGCATCGACAGCGCGGAGCTGAGGAGCCGTGTGCTCTACCGTGGCGCCACCGGCGAAGTGAGGCACGCCGGCGACGAGCCATTCAGCGAGTTCATTAAGTTGGCGAGGAGGCTTACCATACTAACCGACGCCGGGAGCGACAACTTAGGGAGCTAG - >LOC_Os02g41800.2
ATGATCACGTTCGCGGACCTGGCGGAGCCGGCGCCCGGCGCCGAGCGGTGCGTCGACCGGCAGCTGTGGCTGGCGTGCGCGGGGGGCATGTGCACCGTGCCGCCGGTGGGCGCCGCCGTGTACTACTTCCCGCAGGGGCACGCCGAGCACGCGCTCGGCCTCGCCGCGCCGGAGCTCTCCGCGGCGCGCGTCCCGGCGCTCGTGCCCTGCCGCGTCGCGTCCGTGCGGTACATGGCCGACCCGGACACCGACGAGGTGTTCGCCAGGATCCGCCTCGTGCCGCTCCGCGCCGCGGAGGATGGGGACGTCGAGGAGGATGGCGCCGCGGCAGGCGAGGAGCACGAGAAGCCGGCGTCGTTCGCCAAGACGCTGACGCAGTCGGATGCCAACAACGGCGGGGGGTTCTCGGTGCCCAGGTACTGCGCCGAGACCATCTTCCCGCGCCTGGACTACGCCGCCGACCCGCCCGTGCAGACCGTCGTCGCCAAGGACGTCCATGGAGTCGCCTGGAACTTCCGCCACATCTACAGGGGCACGCCGCGCCGGCACCTGCTCACCACGGGGTGGAGCACGTTCGTGAACCAGAAGAAGCTCGTGGCCGGCGACTCCATCGTGTTCCTCCGCGGCGACGGAGGGGACCTGCACGTCGGCATCCGGCGCGCCAAGCGCGGGTTTTGCGGCGGCGGAGGCGGAGCCGAGGAGGCCTCCCTGCCCGGGTGGGACCAGTACGGCGGCCTGATGCGAGGCAATGCGAGCCCGTGCGCGGCCGCCAAGGGGCGGGGCAAGGTGCGCGCGGAGGACCTCGTCGAGGCGGCGAGGCTGGCGAACGGCGGGCAGCCGTTCGAGGTCGTGTACTACCCGCGCGCCAGCACGCCGGAGTTCTGCGTGCGCGCGGCGGCGGTCCGCGCGGCGATGCGGGTGCAGTGGTGCCCCGGGATGCGGTTCAAGATGGCGTTCGAGACCGAGGACTCCTCCCGGATCAGCTGGTTCATGGGCACCGTCGCCAGCGTCCAGGTCGCCGACCCCATCCGTTGGCCGCAGTCGCCGTGGCGGCTTCTCCAGGTGACCTGGGACGAACCGGACCTCCTCCAGAACGTGAAGCGGGTGAGCCCATGGTTGGTCGAGCTGGTGTCGAGCATGCCGGCCATCAACCTCTCGTCTTTCTCGCCGCCGCGCAAGAAGCCCCGGATTCTGGCGTACCCGGAGTTCCCCTTCGAGGGGCAGCTCCTCAACCCGGCGTTCCCGCCAAACCCGCTGGCACACGGCCACCACCATTACCATCACAACCACCCGTCCTTCTTCCCGTTCCCCGACGTTAGTGCTCCTGCAGGCATACAGGGAGCCAGGCATGCGCAATTTGGTCCATCTTTATCAGATCTCCACCTTACCCACCTGCAGTCGAGCCTCATGTACCCGGGGCTCCGCCGCCCCGATCATGTCGGTCCAACATCCATCCCGCCACCAAGAATCAGCACTGACCTGACAATGGGCAGCTCGCCGCCGGCGCGCGCTCTGTCCATGGGCGCCAAGAAGCCCGACGACGCCAAGCCGCCGGGGCTAATGCTGTTCGGGCAGAGGATACTGACCGAGCGCCAGATGAGCCTTAGCGGCACCACCTCGCCGGCGGCCACCGGGAACAGCTCTCTCAACTGGAACACCGAGAAAGGTGCCTCGGAGGGCTCGGGCTCCGGCGTCATCCAGAACAGCCCCACCGACAACACGTCGTCGGAGAGGCTCCAGTGGTTCAGGGAGAACAGCACCGTCTCCGAGCTCGGGCTGGAGCCCGGGCAGTGCAAGGTGTTCATCGAGTCCGACACGGTCGGCCGCAACCTCGACCTCTCGTCGCTGGCCTCGTTCGAGCAGCTCTACGGCCGGCTGTCCGAGATGTTCTGCATCGACAGCGCGGAGCTGAGGAGCCGTGTGCTCTACCGTGGCGCCACCGGCGAAGTGAGGCACGCCGGCGACGAGCCATTCAGCGAGTTCATTAAGTTGGCGAGGAGGCTTACCATACTAACCGACGCCGGGAGCGACAACTTAGGGAGCTAG
Protein Sequence
- >LOC_Os02g41800.1
MITFADLAEPAPGAERCVDRQLWLACAGGMCTVPPVGAAVYYFPQGHAEHALGLAAPELSAARVPALVPCRVASVRYMADPDTDEVFARIRLVPLRAAEDGDVEEDGAAAGEEHEKPASFAKTLTQSDANNGGGFSVPRYCAETIFPRLDYAADPPVQTVVAKDVHGVAWNFRHIYRGTPRRHLLTTGWSTFVNQKKLVAGDSIVFLRGDGGDLHVGIRRAKRGFCGGGGGAEEASLPGWDQYGGLMRGNASPCAAAKGRGKVRAEDLVEAARLANGGQPFEVVYYPRASTPEFCVRAAAVRAAMRVQWCPGMRFKMAFETEDSSRISWFMGTVASVQVADPIRWPQSPWRLLQVTWDEPDLLQNVKRVSPWLVELVSSMPAINLSSFSPPRKKPRILAYPEFPFEGQLLNPAFPPNPLAHGHHHYHHNHPSFFPFPDVSAPAGIQGARHAQFGPSLSDLHLTHLQSSLMYPGLRRPDHVGPTSIPPPRISTDLTMGSSPPARALSMGAKKPDDAKPPGLMLFGQRILTERQMSLSGTTSPAATGNSSLNWNTEKGASEGSGSGVIQNSPTDNTSSERLQWFRENSTVSELGLEPGQCKVFIESDTVGRNLDLSSLASFEQLYGRLSEMFCIDSAELRSRVLYRGATGEVRHAGDEPFSEFIKLARRLTILTDAGSDNLGS* - >LOC_Os02g41800.2
MITFADLAEPAPGAERCVDRQLWLACAGGMCTVPPVGAAVYYFPQGHAEHALGLAAPELSAARVPALVPCRVASVRYMADPDTDEVFARIRLVPLRAAEDGDVEEDGAAAGEEHEKPASFAKTLTQSDANNGGGFSVPRYCAETIFPRLDYAADPPVQTVVAKDVHGVAWNFRHIYRGTPRRHLLTTGWSTFVNQKKLVAGDSIVFLRGDGGDLHVGIRRAKRGFCGGGGGAEEASLPGWDQYGGLMRGNASPCAAAKGRGKVRAEDLVEAARLANGGQPFEVVYYPRASTPEFCVRAAAVRAAMRVQWCPGMRFKMAFETEDSSRISWFMGTVASVQVADPIRWPQSPWRLLQVTWDEPDLLQNVKRVSPWLVELVSSMPAINLSSFSPPRKKPRILAYPEFPFEGQLLNPAFPPNPLAHGHHHYHHNHPSFFPFPDVSAPAGIQGARHAQFGPSLSDLHLTHLQSSLMYPGLRRPDHVGPTSIPPPRISTDLTMGSSPPARALSMGAKKPDDAKPPGLMLFGQRILTERQMSLSGTTSPAATGNSSLNWNTEKGASEGSGSGVIQNSPTDNTSSERLQWFRENSTVSELGLEPGQCKVFIESDTVGRNLDLSSLASFEQLYGRLSEMFCIDSAELRSRVLYRGATGEVRHAGDEPFSEFIKLARRLTILTDAGSDNLGS*