Gene Details:

• MSU gene ID: LOC_Os02g31140
• RAPdb gene ID: Os02g0516400
• Gene Symbol: CFL1
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• We overexpressed both rice and Arabidopsis CFL1 in Arabidopsis thaliana; these transgenic plants showed severely impaired cuticle development, similar to that in CFL1 rice.
• Reduced expression of At CFL1 resulted in reinforcement of cuticle structure.
• Suppression of HDG1 function resulted in similar defective cuticle phenotypes in wild-type Arabidopsis but much alleviated phenotypes in At CFL1-1 mutants.
• The expression of two cuticle development-associated genes, BDG and FDH, was downregulated in At CFL1 overexpressor and HDG1 suppression plants.
• Our results suggest that rice and Arabidopsis CFL1 negatively regulate cuticle development by affecting the function of HDG1, which regulates the downstream genes BDG and FDH.
• CFL1, a WW domain protein, regulates cuticle development by modulating the function of HDG1, a class IV homeodomain transcription factor, in rice and Arabidopsis.
• Biochemical evidence showed that At CFL1 interacts with HDG1, a class IV homeodomain-leucine zipper transcription factor.
• We identified a rice (Oryza sativa) dominant curly leaf mutant, curly flag leaf1 (CFL1), and cloned CFL1, which encodes a WW domain protein.

Function-related keywords:

• cuticle ,  transcription-factor ,  leaf

Literature:

• CFL1, a WW domain protein, regulates cuticle development by modulating the function of HDG1, a class IV homeodomain transcription factor, in rice and Arabidopsis .  DOI:  10.1105/tpc.111.088625 ;  PMID:  21954461

Related News:

Gene Resources:

• NCBI ID: Q67UM8
• UniProt accessions:

Sequences: