Gene Details:

• MSU gene ID: LOC_Os01g72880
• RAPdb gene ID: Os01g0958900
• Gene Symbol: OsMLH1 PSSR1
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• OsMLH3 and OsMLH1 (MutL-homolog 1) interact to form a heterodimer (MutL) to promote crossover formation in the macrospore and microspore mother cells and development of functional megaspore during meiosis, defective OsMLH3 or OsMLH1 in fsv1 and CRISPR/Cas9-based knockout lines results in reduced type I crossover and bivalent frequency.
• OsMLH1 interacts with OsMLH3 to regulate synapsis and interference-sensitive crossover formation during meiosis in rice.
• Here, we report the identification of OsMLH1 and reveal its functions during meiosis in rice.
• A retrotransposon insertion in MUTL-HOMOLOG 1 affects wild rice seed set and cultivated rice crossover rate.

Function-related keywords:

• development ,  microspore ,  crossover ,  meiosis ,  seed-set

Literature:

• Rapid generation of rice mutants via the dominant negative suppression of the mismatch repair protein OsPMS1 .  DOI:  10.1007/s00122-012-1888-5 ;  PMID:  22688271
• Rice MutLγ, the MLH1-MLH3 heterodimer, participates in the formation of type I crossovers and regulation of embryo sac fertility .  DOI:  10.1111/pbi.13563 ;  PMID:  33544956
• OsMLH1 interacts with OsMLH3 to regulate synapsis and interference-sensitive crossover formation during meiosis in rice .  DOI:  10.1016/j.jgg.2021.04.011 ;  PMID:  34257043
• A retrotransposon insertion in MUTL-HOMOLOG 1 affects wild rice seed set and cultivated rice crossover rate .  DOI:  10.1093/plphys/kiac378 ;  PMID:  35976143

Related News:

Gene Resources:

• NCBI ID:
• UniProt accessions:

Sequences: