Information report for RAD51C
Gene Details
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Functional Descriptions
- These results suggest that RAD51C is essential for reproductive development by regulating meiosis as well as for DNA damage repair in somatic cells.
- The rice RAD51C gene is required for the meiosis of both female and male gametocytes and the DNA repair of somatic cells.
- Transferring RAD51C to the RAD51C-KO line restored fertility.
- The RAD51C-KO line showed no obvious difference from wild-type plants in mitosis in the anther wall cells, which was consistent with the observation that the RAD51C-KO line did not have obviously abnormal morphology during vegetative development.
- Cytological analyses showed that the sterility of RAD51C-KO plants was associated with abnormal early meiotic processes in both megasporocytes and pollen mother cells (PMCs).
- Knockout (KO) of RAD51C resulted in both female and male sterility in rice.
Functional Keywords
- meiosis , fertility , reproductive , anther , mitosis , pollen , meiotic , vegetative , sterility
Literature and News
- The rice RAD51C gene is required for the meiosis of both female and male gametocytes and the DNA repair of somatic cells . DOI: 10.1093/jxb/ers190 ; PMID: 22859673
- OsRAD51D promotes homologous pairing and recombination by preventing nonhomologous interactions in rice meiosis . DOI: 10.1111/nph.16595 ; PMID: 32275774
- Rice OsBRCA2 Is Required for DNA Double-Strand Break Repair in Meiotic Cells . DOI: 10.3389/fpls.2020.600820 ; PMID: 33304374
Gene Resources
- UniProt: Q657Q9
- EMBL: AK068701, AP003310
- AlphaFoldDB: Q657Q9
- EnsemblPlants: Os01t0578000-02
- Gramene: Os01t0578000-02
- InterPro: IPR013632, IPR020588, IPR027417
- PANTHER: PTHR46239, PTHR46239:SF1
- SUPFAM: SSF52540
- PROSITE: PS50162
- Gene3D: 3.40.50.300
- OrthoDB: Q657Q9
- Conserved Domain Database: cd19492
Sequences
cDNA Sequence
- >LOC_Os01g39630.2
AAAAAAAAAAACCATCGCCAGTCGCCGCCCGCGCGGAGCATCCATCCTCAACCTCCCAAGTTCGGCGCCCAATCCCGGCGATGGAGATCGCCGACCTCCCCATCGCCACCTCCCACCGCGCCAACCTCCTCGCCGCCGGCTACTCCTCCCTCGCCGCGCTCTCCGCCGCCTCCCCTCCCCGCCTCGCCCGAGATTTGAGCATTGAGGTACATGAGGCTGAAGAAATCCTCAAGGTTGCCGTGGGCGCCAACAAGTCCAAGGGAGCAGATGGGCCTAGCACCAGCAGTGTTCTCAAAGGTGTGCAAAATGCATGGGATATGCTATCTGATGAGCAATCACGGAGGCACATCAATACTGGATCTGCTGACCTCAACAACATCCTTGGTGGAGGGATTCACTGTAAAGAGGTTACTGAGATTGTTTGATTCAGGTGGTGTCCCAGGAGTCGGTAAAACTCAACTGGGGATTCAACTAGCAATCAATGTTCAAATTCCAGTGGAGTATGGTGGACTTGGTGGGAAAGCTGTTTATATAGATACAGAGGGAAGTTTCATGGTTGAACGTGTCTACCAAATTGCTGAAGGGTGCATCAGTGATATACTGGAGTACTTTCCACACTGCCATGACAAGGCTCCAGCCGGACAAGAAAAACTGAAGCCTGAGAGTTTCCTGGCTGACATCTACTACTTTCGAATATGCAGCTATACTGAACAAATTGCAGTCATAAACTATCTGGAAAAGTTTCTTGGGGAGCATAAAGATGTAAGAATAGTTATTATTGACAGCGTTACTTTCCACTTTCGGCAAGATTTTGATGATATGGCACTAAGGACTAGAGTGCTTAGTGGATTATCATTGAAGTTGATGAAACTTTCAAAGGCATATAACTTGGCGGTTGTCTTGTTGAACCAAGTTACTACTAAATTCACAGAAGGATCATTTCAGTTAACTCTTGCTCTAGGTGACAGTTGGTCCCACTCATGCACCAATCGACTAATTCTGTATTGGAACGGCAATGAGCGGTATGGATTCCTGGACAAGTCCCCTTCACTACCAGTAGCATCAGCACCATATGCAGTGACAGTTAAAGGGGTGAGAGATGCTGTGAATTCAAACAGCAAGCGAGTCCGGGTAATGTAGCAATCTTGGTGTTGAACCCTTTTACCATTAGTAGCCATCGACCGTCATGTCTAAACTGTGCAGCATTCTCTGATCTTTCTAACTAAGCTGATTGAAATTTGGATCATGTGTAACGCTGTCTTATTTGCTTCTGCCGGTAGCTAATTGTACAAAGGTAACTGAAGCAAAAGAGGGTGCTTCATTTTGGTTGATCCAAACATGTAACAGCTAACAAGTACTCTACAGGCCTGTTACAAACTTACAAACAGAATGATGCCGGATGTGTTCCGATGCCAGGAAATTATCCTCGTTTTTTCATGGGCTTTGCCTTTCAGTTTCTAGTCATGCCAAGCTGTGTAAACTGGGTGCTGGTTTTGGAGCAGTGACCGGTGAACAGTGACCCGTGAACTTTCACTTTATTCTGAGCTGTGCTTCTACTAGTTTGAGGAATAAAGCGAAAGTTCTTGGTATATGTCGAGGATTGGTAGAGTTTGCGTGTTTTATAGAATTGAATTAAACCATGCTCCACTCCTGCTTGTGCAGGGCCTCCCCTG - >LOC_Os01g39630.1
AAAAAAAAAAACCATCGCCAGTCGCCGCCCGCGCGGAGCATCCATCCTCAACCTCCCAAGTTCGGCGCCCAATCCCGGCGATGGAGATCGCCGACCTCCCCATCGCCACCTCCCACCGCGCCAACCTCCTCGCCGCCGGCTACTCCTCCCTCGCCGCGCTCTCCGCCGCCTCCCCTCCCCGCCTCGCCCGAGATTTGAGCATTGAGGTACATGAGGCTGAAGAAATCCTCAAGGTTGCCGTGGGCGCCAACAAGTCCAAGGGAGCAGATGGGCCTAGCACCAGCAGTGTTCTCAAAGGTGTGCAAAATGCATGGGATATGCTATCTGATGAGCAATCACGGAGGCACATCAATACTGGATCTGCTGACCTCAACAACATCCTTGGTGGAGGGATTCACTGTAAAGAGGTTACTGAGATTGTTTGATTCAGGTGGTGTCCCAGGAGTCGGTAAAACTCAACTGGGGATTCAACTAGCAATCAATGTTCAAATTCCAGTGGAGTATGGTGGACTTGGTGGGAAAGCTGTTTATATAGATACAGAGGGAAGTTTCATGGTTGAACGTGTCTACCAAATTGCTGAAGGGTGCATCAGTGATATACTGGAGTACTTTCCACACTGCCATGACAAGGCTCCAGCCGGACAAGAAAAACTGAAGCCTGAGAGTTTCCTGGCTGACATCTACTACTTTCGAATATGCAGCTATACTGAACAAATTGCAGTCATAAACTATCTGGAAAAGTTTCTTGGGGAGCATAAAGATGTAAGAATAGTTATTATTGACAGCGTTACTTTCCACTTTCGGCAAGATTTTGATGATATGGCACTAAGGACTAGAGTGCTTAGTGGATTATCATTGAAGTTGATGAAACTTTCAAAGGCATATAACTTGGCGGTTGTCTTGTTGAACCAAGTTACTACTAAATTCACAGAAGGATCATTTCAGTTAACTCTTGCTCTAGGTGACAGTTGGTCCCACTCATGCACCAATCGACTAATTCTGTATTGGAACGGCAATGAGCGGTATGGATTCCTGGACAAGTCCCCTTCACTACCAGTAGCATCAGCACCATATGCAGTGACAGTTAAAGGGGTGAGAGATGCTGTGAATTCAAACAGCAAGCGAGTCCGGGTAATGTAGCAATCTTGGTGTTGAACCCTTTTACCATTAGTAGCCATCGACCGTCATGTCTAAACTGTGCAGCATTCTCTGATCTTTCTAACTAAGCTGATTGAAATTTGGATCATGTGTAACGCTGTCTTATTTGCTTCTGCCGGTAGCTAATTGTACAAAGGTAACTGAAGCAAAAGAGGGTGCTTCATTTTGGTTGATCCAAACATGTAACAGCTAACAAGTACTCTACAGGCCTGTTACAAACTTACAAACAGAATGATGCCGGATGTGTTCCGATGCCAGGAAATTATCCTCGTTTTTTCATGGGCTTTGCCTTTCAGTTTCTAGTCATGCCAAGCTGTGTAAACTGGGTGCTGGTTTTGGAGCAGTGACCGGTGAACAGTGACCCGTGAACTTTCACTTTATTCTGAGCTGTGCTTCTACTAGTTTGAGGAATAAAGCGAAAGTTCTTGGTATATGTCGAGGATTGGTAGAGTTTGCGTGTTTTATAGAATTGAATTAAACCATGCTCCACTCCTGCTTGTGCAGGGCCTCCCCTG
CDS Sequence
- >LOC_Os01g39630.2
ATGAGGCTGAAGAAATCCTCAAGGTTGCCGTGGGCGCCAACAAGTCCAAGGGAGCAGATGGGCCTAGCACCAGCAGTGTTCTCAAAGGTGTGCAAAATGCATGGGATATGCTATCTGATGAGCAATCACGGAGGCACATCAATACTGGATCTGCTGACCTCAACAACATCCTTGGTGGAGGGATTCACTGTAAAGAGGTTACTGAGATTGTTTGATTCAGGTGGTGTCCCAGGAGTCGGTAAAACTCAACTGGGGATTCAACTAGCAATCAATGTTCAAATTCCAGTGGAGTATGGTGGACTTGGTGGGAAAGCTGTTTATATAGATACAGAGGGAAGTTTCATGGTTGAACGTGTCTACCAAATTGCTGAAGGGTGCATCAGTGATATACTGGAGTACTTTCCACACTGCCATGACAAGGCTCCAGCCGGACAAGAAAAACTGAAGCCTGAGAGTTTCCTGGCTGACATCTACTACTTTCGAATATGCAGCTATACTGAACAAATTGCAGTCATAAACTATCTGGAAAAGTTTCTTGGGGAGCATAAAGATGTAAGAATAGTTATTATTGACAGCGTTACTTTCCACTTTCGGCAAGATTTTGATGATATGGCACTAAGGACTAGAGTGCTTAGTGGATTATCATTGAAGTTGATGAAACTTTCAAAGGCATATAACTTGGCGGTTGTCTTGTTGAACCAAGTTACTACTAAATTCACAGAAGGATCATTTCAGTTAACTCTTGCTCTAGGTGACAGTTGGTCCCACTCATGCACCAATCGACTAATTCTGTATTGGAACGGCAATGAGCGGTATGGATTCCTGGACAAGTCCCCTTCACTACCAGTAGCATCAGCACCATATGCAGTGACAGTTAAAGGGGTGAGAGATGCTGTGAATTCAAACAGCAAGCGAGTCCGGGTAATGTAG - >LOC_Os01g39630.1
ATGAGGCTGAAGAAATCCTCAAGGTTGCCGTGGGCGCCAACAAGTCCAAGGGAGCAGATGGGCCTAGCACCAGCAGTGTTCTCAAAGGTGTGCAAAATGCATGGGATATGCTATCTGATGAGCAATCACGGAGGCACATCAATACTGGATCTGCTGACCTCAACAACATCCTTGGTGGAGGGATTCACTGTAAAGAGGTTACTGAGATTGTTTGATTCAGGTGGTGTCCCAGGAGTCGGTAAAACTCAACTGGGGATTCAACTAGCAATCAATGTTCAAATTCCAGTGGAGTATGGTGGACTTGGTGGGAAAGCTGTTTATATAGATACAGAGGGAAGTTTCATGGTTGAACGTGTCTACCAAATTGCTGAAGGGTGCATCAGTGATATACTGGAGTACTTTCCACACTGCCATGACAAGGCTCCAGCCGGACAAGAAAAACTGAAGCCTGAGAGTTTCCTGGCTGACATCTACTACTTTCGAATATGCAGCTATACTGAACAAATTGCAGTCATAAACTATCTGGAAAAGTTTCTTGGGGAGCATAAAGATGTAAGAATAGTTATTATTGACAGCGTTACTTTCCACTTTCGGCAAGATTTTGATGATATGGCACTAAGGACTAGAGTGCTTAGTGGATTATCATTGAAGTTGATGAAACTTTCAAAGGCATATAACTTGGCGGTTGTCTTGTTGAACCAAGTTACTACTAAATTCACAGAAGGATCATTTCAGTTAACTCTTGCTCTAGGTGACAGTTGGTCCCACTCATGCACCAATCGACTAATTCTGTATTGGAACGGCAATGAGCGGTATGGATTCCTGGACAAGTCCCCTTCACTACCAGTAGCATCAGCACCATATGCAGTGACAGTTAAAGGGGTGAGAGATGCTGTGAATTCAAACAGCAAGCGAGTCCGGGTAATGTAG
Protein Sequence
- >LOC_Os01g39630.2
MRLKKSSRLPWAPTSPREQMGLAPAVFSKVCKMHGICYLMSNHGGTSILDLLTSTTSLVEGFTVKRLLRLFDSGGVPGVGKTQLGIQLAINVQIPVEYGGLGGKAVYIDTEGSFMVERVYQIAEGCISDILEYFPHCHDKAPAGQEKLKPESFLADIYYFRICSYTEQIAVINYLEKFLGEHKDVRIVIIDSVTFHFRQDFDDMALRTRVLSGLSLKLMKLSKAYNLAVVLLNQVTTKFTEGSFQLTLALGDSWSHSCTNRLILYWNGNERYGFLDKSPSLPVASAPYAVTVKGVRDAVNSNSKRVRVM* - >LOC_Os01g39630.1
MRLKKSSRLPWAPTSPREQMGLAPAVFSKVCKMHGICYLMSNHGGTSILDLLTSTTSLVEGFTVKRLLRLFDSGGVPGVGKTQLGIQLAINVQIPVEYGGLGGKAVYIDTEGSFMVERVYQIAEGCISDILEYFPHCHDKAPAGQEKLKPESFLADIYYFRICSYTEQIAVINYLEKFLGEHKDVRIVIIDSVTFHFRQDFDDMALRTRVLSGLSLKLMKLSKAYNLAVVLLNQVTTKFTEGSFQLTLALGDSWSHSCTNRLILYWNGNERYGFLDKSPSLPVASAPYAVTVKGVRDAVNSNSKRVRVM*