Gene Details:

• Gene ID: MDP0000123888
• Gene Symbol: MdWRKY75
• Gene Name: WRKY transcription factor 75
• Genome: Golden ASM211411v1
• Species: Malus domestica

Functional Descriptions:

• Functional analysis of MdWRKY75 in the regulation of anthocyanin accumulation.
• Overexpressing MdWRKY75 promoted anthocyanin accumulation by activating the expression of MdMYB1 and anthocyanin biosynthetic genes , whereas the opposite trend was observed when we suppressed MdWRKY75 expression.
• MdPHR1 interacted with MdWRKY75 to enhance the MdWRKY75-activated transcription of MdMYB1, the master regulator of anthocyanin biosynthesis, leading to anthocyanin accumulation.
• MdPHR1 interacted with MdWRKY75, a positive regulator of anthocyanin biosynthesis, to enhance the MdWRKY75-activated transcription of MdMYB1, leading to anthocyanin accumulation. In addition, the E3 ubiquitin ligase SEVEN IN ABSENTIA1 (MdSINA1) negatively regulated MdPHR1-promoted anthocyanin biosynthesis via the ubiquitination-mediated degradation of MdPHR1.
• Transient overexpression of MdWRKY75 could significantly increase the sucrose content and promote the expression of MdSWEET1 in apple fruit.

Function-related keywords:

• transcription-regulator ,  ubiquitin ,  ubiquitin-e3-ligase ,  anthocyanin-biosynthesis

Literature:

• The E3 ubiquitin ligase SINA1 and the protein kinase BIN2 cooperatively regulate PHR1 in apple anthocyanin biosynthesis.   DOI:  10.1111/jipb.13538 ;  PMID:  37272713
• Comparative physiological and transcriptomic analysis reveal MdWRKY75 associated with sucrose accumulation in postharvest ‘Honeycrisp’ apples with bitter pit.   DOI:  10.1186/s12870-022-03453-8 ;  PMID:  35176994

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Gene Resources:

• NCBI ID:
• UniProt accessions:

Sequences: