Gene Details:

• Gene ID:
• Gene Symbol: MdSQS1
• Gene Name: squalene synthase 1
• Genome: Golden ASM211411v1
• Species: Malus domestica

Functional Descriptions:

• Virus-induced gene silencing of the two squalene synthase isoforms of apple tree (Malus × domestica L.) negatively impacts phytosterol biosynthesis, plastid pigmentation and leaf growth.
• The concomitant down-regulation of both MdSQS isoforms strongly affected phytosterol synthesis without alteration in triterpene accumulation, since triterpene-specific oxidosqualene synthases were found to be up-regulated to compensate metabolic flux reduction.
• MdSQS silencing in apple tree by VIGS leads to abnormal leaves.
• The squalene synthesis activity of MdSQS1 and MdSQS2 was finally demonstrated in vitro using yeast crude extracts.

Function-related keywords:

• leaf ,  growth ,  plastid ,  pigmentation ,  virus

Literature:

• Virus-induced gene silencing of the two squalene synthase isoforms of apple tree (Malus × domestica L.) negatively impacts phytosterol biosynthesis, plastid pigmentation and leaf growth.   DOI:  10.1007/s00425-017-2681-0 ;  PMID:  28349256

Related News:

Gene Resources:

• NCBI ID: KC895979.1
• UniProt accessions: S5VRK5

Orthologs:

Sequences: