Gene Details:

Functional Descriptions:

  • A small ubiquitin-like modifier (SUMO) E3 ligase, SAP AND MIZ1 DOMAIN CONTAINING LIGASE1 (MdSIZ1), regulates wax accumulation and cuticle permeability in apple (Malus domestica Borkh), SUMO E2 CONJUGATING ENZYME 1(MdSCE1) physically interacts with MdMYB30, a transcription factor involved in the regulation of cuticle wax accumulation.
  • Apple SUMO E3 ligase MdSIZ1 regulates cuticular wax biosynthesis by SUMOylating transcription factor MdMYB30.
  • These findings indicate that the MdSIZ1–MdMYB30–MdKCS1 module positively regulates cuticular wax biosynthesis in apples.
  • MdSIZ1 promotes wax accumulation in a MdMYB30-dependent manner.
  • Apple SUMO E3 ligase MdSIZ1 facilitates SUMOylation of MdARF8 to regulate lateral root formation.
  • MdSIZ1 enhanced the conjugating enzyme activity of MdSCE1 to form a MdSCE1–MdSIZ1–MdARF8 complex, thereby facilitating SUMO modification.
  • The small ubiquitin-like modifier E3 ligase MdSIZ1 promotes anthocyanin accumulation by sumoylating MdMYB1 under low-temperature conditions in apple.
  • MdSIZ1 overexpression exerted a large positive influence on anthocyanin accumulation and red fruit coloration, suggesting its important role in the regulation of anthocyanin biosynthesis under stress conditions.

Literature:

Gene Resources:

Sequences:

cDNA Sequence
mRNA Sequence
  • />MD11G1131700
    TTGGTTCTGGTTGGGGGTCTTCGGTCAAAATAGAAAAAAAACGCAAAAACGATTACAGGGACGAAGAACAAGTAGCAGTATCGCAAAGTCGGCGCTCGGAAAAAACCCTAGACTCCCTCCCCCAATTCGATCAACAAAATCGGTCCCTGAGGAGGCTATGTGCTCGTTTTTCTGGTTTGGTGGTTGATTAAATTATTGGTCCGGAGGTGATTGTGTACTTTCTGGGCCTTCATTTTTGGCGGAGAAAATGGATTTGGTAGCTAGTTGCAAGGAAAAATTGGCATATTTTCGAATAAAAGAGCTCAAAGATGTTCTCACTGAATTAGGTCTATCAAAGCAGGGGAAGAAGCAGGATCTTGTTGACCGGATATTGGCCATTCTTTCTGATGAACAAGTCTCTAAAATGTGGGCAAAAAAGAATGCAGTTGGAAAGGAACAGGTGGCGGAACTTGTAGATCACACCTATAGAAAAATGCAGATTTCCGGTGCCCCTGATTTAGCATCAAAGGGACAATGCATCTCTGATAGTAGTAATGTGAAAATAAGAGGCGAAATTGAGGATCCCTACCAGTCAGCTATCAAGGTTCGCTGTCTCTGTGGGAATTCATTAGAAACAGAGTCAATGATTAAGTGTGAAGATCCAAGATGCCAAGTGTGGCAACACATGGGTTGCGTTATAGTTCCAGAGAAACCTATGGAAGGCAATCCACCAGTTCCCGAATTATTTTATTGTGAACTCTGTCGACTAAGTCGGGCTGATCCGTTTTGGGTAACGATTCAACATCCTTTACAGCCTGTTAAGTTGCATGTTACAAATATTCCAGCTGATGGTTCGAATCCAGTGCAAAGTGTGGAGAAAACGTTTCAACTCACAAGGGCAGACAAGGACCTGATGTCTAAACAAGAATATGATGTTCAGGTTTGGTGTATGCTTTTAAATGACAAAGTTGCATTCAGGATGCAATGGCCGCAATATGCAGATCTACAGGTCAATGGTATGCCTGTTCGTGCAATCAATAGACCTGGCTCGCAACTTCTTGGAGCTAATGGTCGTGATGATGGTCCAATTATCACACCATATACGAAAGACGGATTTAATAAGATTTCCTTAACAGGATGCGATGCCCGCATTTTCTGCTTAGGGGTTCGTATTGTGAAGAGACGCACAGTGCAACAGATTCTCAACCTGATTCCCAAGGAGTCTGATGGTGAGGGTTTTGAAGATGCGCTTGCTCGTGTGTGTCGATGTGTTGGTGGTGGGACTGCTACGGATAATGATGATAGTGACAGTGATTTGGAAGTTGTTGCAGATTCTTTTACTGTCAATCTACGTTGTCCGATGAGTGGTTCAAGAATGAAGGTTGCTGGGAGATTCAAGCCCTGCCCTCACATGGGCTGTTTTGATCTTGACGTTTTTGTGGAAATGAATCAACGTTCAAGGAAGTGGCAATGCCCCATTTGTCTCAAGAACTATGCGCTGGAGAATATCATTATCGACCCTTATTTCAACCGTATCACTTCAAAGATGAGGTATTGTGGAGAGGATGTAGCAGAGATTGAGGTGAAGCCTGATGGGTCTTGGCGAGTTAAGACTAAAAGTGAAAGTGATCGCAGGGAGCTTGGGGAACTTGGTCAGTGGCACCTGCCTGATGGTACACTTAGTGTCCCGACAGAAGGAGAAAGTATCCCAAAAACGGAAGTGTTGAAGCAGGTCAAACAGGAAGGTGTTTCAGAAGCTCATACTGGATTGAAACTTGGAATCAGGAAGAATCGCAATGGCTTTTGGGAAGTCAGCAAACCTGAAGATATGAACACTTCTTCTGGTAATAGATTACAAGAGCAGTTTGCAGACCATGAGCTAAAAGTTATCCCAATGAGTAGCAGTGCCACTGGAAGTGGTAGGGATGGCGAAGATGCAAGTGTTAATCAGGATGGTGGTGGAAACTTTGATTTCTCAACTAACAATGGAATTGAGATGGATTCTCTTTCTCTGAATGTTGATTCAGCATATGGATTTTCAGGACAAAATCCTTCTGCACCAGTAGGAGACGCAGAAGTTATTGTACTAAGTGATTCTGATGATGATATAATGCCCTCTGGAACCATCTATATGAATGACAGAACTGATGCTGCTGGGCTTGGTTTTCCTGTGGCGCCTTCTGGAATTGCTGATTCATATGGTGAAGATCACACGCTTGGAACTGGTGGGAACTCATGCTTGGGTCTTTTTGGCAACGAAGATGAATTTATTCCACTCTGGCCATTAGCTCCTGGAACTCAATCTGGTGCCGGGTTCCAGTTATTTACTTCTGAGGCAGATGTACCAGATACCCTAGGTGGTCTGCAGCATAGTTCCATCAATTGTTCCACATCCATGAATGGATACACTTTGGCTCCAGAAACTACCATGGGATCTGCTGCCCTAGGACTTGATTCTTCTGTTGCACGTTCAGATGTTGACATGAATGGTGGCTTAGTTGATAACCCAATGGCATTTCCTGGTGATGACCCTTCTCTTCAAATATTTCTTCCCACAAGACCATCTGATGCATCAGTTCATTCTGATTTGAGAGATCAAGCTGATATGTCAAATGGTGTCCACACTGATGATTGGATATCTCTTAGGCTTGGGGGTGACGCCAGTGGCATCAATGGGGCGCCTGCAAGTCCAAACGGTTTGAATTCTAGAATGCAAATGCCATCCAGAGAAGGTGCCATGGATTCTTTGGCTGATACAGCTTCTTTGCTTCTCGGTATGAATGACGGTAGCAGATCTGACAGGACAAGTAGGCAAAGATCAAACAGTCCTTTCTCATTTCCTCGCCAAAAACGTTCTGTGAGACCGCGATTATATCTTTCTATTGACTCGGACTCTGAATAGAGGAACTGGAGCTTGTTTTGAGAACAAGAGAATCTAGTTTTGGGTTTAATTGGAAGAACGCTGACAGACATTTGGTTCCTGACGAGATGAAGCGTTAGATGTTGCACTGGGCATCCGAGGTAGAAGAAAGCGATACAAATATACAAGGCATCCAAATCGACCGCATTGTTACAAAACTTGCGATGGCACCAGGATTCTTCGTGTTCCTCCCGTTAACAATCTGCAGGTCCGATGCTGGTATTGTACAGGAGATTGTGATTTGAATCCGAAAAATTGGGACGTGTCGGAGGAAACCCTGTCAAAGAAATAAAACATGGCTGCCTCGGCTCGGTTTTATAGTGACAAGCAATAGCCTGTAAATATTCACTCCGGCTTCAGTTTTTTTAAATAGATGGTCATTTTTTCGAAAATTGATAATACTGACTTTTTATTGGTGTGTCCATTACTGTTGGGGCATGACATTTGTATTAACTTATAGAGATCCATTTAAAGTACAGGGGATCGGCACTTTGTGCGTCGCGTCGCTCCGATGGCCGACGTTTTAAAGTCATGGTTGCTGCGAGATCATAGTAGAACGCTGACTTCTGGTGAGGCAACAGAGAAATTATACCAAAAAAACTTTTATTATATGTTTTATTGTATTTGGAATGCAATTGAGTTTCATGTTCGGTTATTCCAACTTTATGCAATGTCATCGGATTTCATTTTGTTGTGTAAAAATCCGAGGGCTTTATGATATCCCCACAATTGGATGGAAATTCAAGGGTTTCAAGCTTGCGGCGCAAGTGATTCAGTCTAGCAGTATTGTTCTTCATTTGTAAGTAAT
Protein Sequence
  • />MD11G1131700
    MDLVASCKEKLAYFRIKELKDVLTELGLSKQGKKQDLVDRILAILSDEQVSKMWAKKNAVGKEQVAELVDHTYRKMQISGAPDLASKGQCISDSSNVKIRGEIEDPYQSAIKVRCLCGNSLETESMIKCEDPRCQVWQHMGCVIVPEKPMEGNPPVPELFYCELCRLSRADPFWVTIQHPLQPVKLHVTNIPADGSNPVQSVEKTFQLTRADKDLMSKQEYDVQVWCMLLNDKVAFRMQWPQYADLQVNGMPVRAINRPGSQLLGANGRDDGPIITPYTKDGFNKISLTGCDARIFCLGVRIVKRRTVQQILNLIPKESDGEGFEDALARVCRCVGGGTATDNDDSDSDLEVVADSFTVNLRCPMSGSRMKVAGRFKPCPHMGCFDLDVFVEMNQRSRKWQCPICLKNYALENIIIDPYFNRITSKMRYCGEDVAEIEVKPDGSWRVKTKSESDRRELGELGQWHLPDGTLSVPTEGESIPKTEVLKQVKQEGVSEAHTGLKLGIRKNRNGFWEVSKPEDMNTSSGNRLQEQFADHELKVIPMSSSATGSGRDGEDASVNQDGGGNFDFSTNNGIEMDSLSLNVDSAYGFSGQNPSAPVGDAEVIVLSDSDDDIMPSGTIYMNDRTDAAGLGFPVAPSGIADSYGEDHTLGTGGNSCLGLFGNEDEFIPLWPLAPGTQSGAGFQLFTSEADVPDTLGGLQHSSINCSTSMNGYTLAPETTMGSAALGLDSSVARSDVDMNGGLVDNPMAFPGDDPSLQIFLPTRPSDASVHSDLRDQADMSNGVHTDDWISLRLGGDASGINGAPASPNGLNSRMQMPSREGAMDSLADTASLLLGMNDGSRSDRTSRQRSNSPFSFPRQKRSVRPRLYLSIDSDSE