Gene Details:

Functional Descriptions:

  • The E3 ubiquitin ligases SINA1 and SINA2 integrate with the protein kinase CIPK20 to regulate the stability of RGL2a, a positive regulator of anthocyanin biosynthesis.
  • In this study, we report the ubiquitination and phosphorylation of an apple DELLA protein MdRGL2a in response to GA signaling and its regulatory role in anthocyanin biosynthesis.
  • MdRGL2a and MdCIPK20 were ubiquitinated and degraded by E3 ubiquitin ligases MdSINA1 and MdSINA2, respectively, both of which were activated in the presence of GA.
  • MdRGL2a could interact with MdWRKY75 to enhance the MdWRKY75-activated transcription of anthocyanin activator MdMYB1 and interfere with the interaction between anthocyanin repressor MdMYB308 and MdbHLH3 or MdbHLH33, thereby promoting anthocyanin accumulation.

Literature:

Gene Resources:

  • NCBI ID:
  • UniProt accessions:

Sequences:

cDNA Sequence
mRNA Sequence
  • />MD09G1264800
    ATGAAGAGAGAACACTGCCATAGCTCTGCAACTGCAAGTCAGAATAATTCCAAACGAGAATACTCATCACCGCCGTCTTCCGCCCTGAACGGCAAGGCCAAGATTTGGGAAGATGAACAAGGCTACAGCGGCGGCGGCGACATGGACGAGCTGCTTGCCGTTTTGGGATACAAGGTTCGGACCGACGACATGGCCGACGTGGCCGAGAAGCTCGAGCAGCTCGAGATGGTCATGGGGTCGGCTCAGGAAGATGGGGTTTCTCAGCTCTCTGACACCGTCCATTACAACCCGTCCGATCTCTCCGGGTGGGTCCAAAGCATGCTCTCTGAGCTCAACACCGGCGACGATATGCCCTCAATCAACGGCCCTCTTCTCGCTCCAGGGGAGTCCTCGACGATAACGTCGACGAGCTTCTGCAATTCCCAGCGGACTCGGGTTTTCAGCGACGATTCCGAATACGATCTCAGGGCTATTCCTGGCGTGGCGGCGTACCCGCCGGCACATTCGTCGTCGGAGACCGAGAGTACGAGAAAGCGATTGAAGAGCTCAATTGGGTCTAATTCCGGCGGGATTGAAGTCTCCGGCGCTGTATCCGACCCGATTCGGCCTCTGGTCCTGGTCGACTCACAAGAAACCGGTGTCCAACTCGTCCACACACTCATGGCCTGTGCTGAGGCTGTCCAGCAGGAAAACTTGAAGCTTGCAGACGCGCTTGTGAAGCACGTGGGCCTACTCGCGGCTGCCCAAACCGGAGCTATGAGGAAAGTCGCCACGTACTTCGCTGAAGCTCTGGCTCGTCGGATTTACCGAATATACCCTCAGGATTGCCTCGATTCTTCCTACTCGGACATTCTCCAGATGCACTTCTACGAGACCTGCCCCTACCTGAAATTTGCTCACTTCACTGCCAACCAGGCAATACTCGAGGCTTTTGCCACGGCGACCAGAGTACACGTCATCGATTTCGGGCTTAAACAGGGGATGCAATGGCCAGCGCTCATGCAGGCGCTGGCACTAAGGCCCGGTGGCCCACCCGTGTTTCGCCTGACGGGTATTGGGCCGCCGCAGCCCGATAACACCGACGTTCTGCAGCAGGTGGGATGGAAGTTGGCTCAATTGGCAGAAACTATTGGGGTCGAGTTTGAATTTCGAGGATTCGTGGCCAATAGCCTGGCTGACCTCGAGCCGTCTATGCTTGACATCCGTCAGGACGAGGCCGTAGCGGTGAATTCGGTTTTCAAGCTTCACGGTCTCTTGGCTCGAGCCGGGGCGGTGGACAAAGTGTTGTCATCAATCAAGGCCATGAAGCCTAAAATTGTGACTATTGTGGAGCAGGAGGCGAACCATAACGGGCCGGTTTTCTTGGACCGGTTCACGGAGGCATTGCATTATTATTCAAGCTTGTTTGACTCTCTGGAGGGATCGTCCGGGCCGAGTCAAGATTTGGTCATGTCCGAGGTCTATTTGGGTAGGCAGATATGCAACGTGGTGGCATGTGAAGGTGGGGACCGAGTTGAGCGACACGAGACGCTGACTCAGTGGCGAGGCCGGATGGACTCCGCCGGGTTCGACCCAGTCCACCTCGGATCGAACGCGTTCAAGCAGGCTAGCATGCTGCTTGATCTTTTCGCCGGCGTAGATGGGTATCGGGTGCAGGAGAACAATGGGTCTCTCATGCTCGGGTGGCACACGCGGCCGCTCATAGTCACCTCGGCTTGGAAGCTGGCGAGCTCAACGGAGTGA
Protein Sequence
  • />MD09G1264800
    MKREHCHSSATASQNNSKREYSSPPSSALNGKAKIWEDEQGYSGGGDMDELLAVLGYKVRTDDMADVAEKLEQLEMVMGSAQEDGVSQLSDTVHYNPSDLSGWVQSMLSELNTGDDMPSINGPLLAPGESSTITSTSFCNSQRTRVFSDDSEYDLRAIPGVAAYPPAHSSSETESTRKRLKSSIGSNSGGIEVSGAVSDPIRPLVLVDSQETGVQLVHTLMACAEAVQQENLKLADALVKHVGLLAAAQTGAMRKVATYFAEALARRIYRIYPQDCLDSSYSDILQMHFYETCPYLKFAHFTANQAILEAFATATRVHVIDFGLKQGMQWPALMQALALRPGGPPVFRLTGIGPPQPDNTDVLQQVGWKLAQLAETIGVEFEFRGFVANSLADLEPSMLDIRQDEAVAVNSVFKLHGLLARAGAVDKVLSSIKAMKPKIVTIVEQEANHNGPVFLDRFTEALHYYSSLFDSLEGSSGPSQDLVMSEVYLGRQICNVVACEGGDRVERHETLTQWRGRMDSAGFDPVHLGSNAFKQASMLLDLFAGVDGYRVQENNGSLMLGWHTRPLIVTSAWKLASSTE