Gene Details:

• Gene ID: MDP0000894463
• Gene Symbol: MdMYB73
• Gene Name: R2R3-MYB transcription factor 73
• Genome: Golden ASM211411v1
• Species: Malus domestica

Functional Descriptions:

• The R2R3-MYB transcription factor (TF) MdMYB73 was identified as a protein that plays a critical role in determining malate accumulation and vacuolar acidification by directly regulating the transcription of aluminum-activated malate transporter 9 (MdALMT9), vacuolar ATPase subunit A (MdVHA-A), and vacuolar pyrophosphatase 1 (MdVHP1) in apple
• BTB-BACK-TAZ domain protein MdBT2-mediated MdMYB73 ubiquitination negatively regulates malate accumulation and vacuolar acidification in apple.
• In this study, we found that MdBT2 directly interacts with and degrades MdMYB73 through the ubiquitin/26S proteasome pathway to regulate malate accumulation and vacuolar acidification.
• A series of functional assays with apple calli and fruit showed that MdBT2 controls malate accumulation and vacuolar acidification in an MdMYB73-dependent manner.
• MdMYB73 can directly regulate the transcription of malate-related genes to adjust malate accumulation and vacuolar acidification.
• These findings help to elucidate how MdMYB73 directly modulates the vacuolar transport system to affect malate accumulation and vacuolar pH in apple.

Function-related keywords:

• transcription-factor ,  atpase ,  transporter ,  aluminum ,  ubiquitin ,  calli

Literature:

• BTB-BACK-TAZ domain protein MdBT2-mediated MdMYB73 ubiquitination negatively regulates malate accumulation and vacuolar acidification in apple.   DOI:  10.1038/s41438-020-00384-z ;  PMID:  32944259
• The R2R3-MYB transcription factor MdMYB73 is involved in malate accumulation and vacuolar acidification in apple.   DOI:  10.1111/tpj.13579 ;  PMID:  28423209

Related News:

• Hortic Res | 山东农业大学郝玉金教授课题组解析苹果中苹果酸积累和液泡酸化的调控机理

Gene Resources:

• NCBI ID:
• UniProt accessions:

Sequences: