Gene Details:

  • Gene ID:
  • Gene Symbol: MdDIPM4
  • Gene Name: Malus domestica DspA/E-interacting proteins of M.4
  • Genome: Golden ASM211411v1
  • Species: Malus domestica

Functional Descriptions:

  • The bacterium Erwinia amylovora, the causal agent of fire blight disease in apple, triggers its infection through the DspA/E effector which interacts with the apple susceptibility protein MdDIPM4.
  • MdDIPM4 knockout has been produced in two Malus × domestica susceptible cultivars using the CRISPR/Cas9 system delivered via Agrobacterium tumefaciens. Fifty-seven transgenic lines were screened to identify CRISPR/Cas9-induced mutations.
  • MdDIPM4 is involved in apple susceptibility to fire blight and that the inactivation of this single gene of the DIPM family is sufficient to significantly reduce disease symptoms.
  • The knockout of MdDIPM4 resulted in a highly significant reduction in susceptibility, on average 50% in both cultivars.

Literature:

Gene Resources:

  • NCBI ID:
  • UniProt accessions:

Sequences:

cDNA Sequence
CDS Sequence
Protein Sequence