Gene Details:

Functional Descriptions:

  • F-box protein MdAMR1L1 regulates ascorbate biosynthesis in apple by modulating GDP-mannose pyrophosphorylase.
  • This occurred because the MdAMR1L1 protein interacted with MdGMP1 and promoted its degradation via the ubiquitination pathway to inhibit Asc synthesis at the post-translational level.
  • The overexpression or silencing of MdAMR1L1 in apple indicated that MdAMR1L1 negatively regulated Asc levels.
  • This occurred because the MdAMR1L1 protein interacted with MdGMP1 and promoted its degradation via the ubiquitination pathway to inhibit Asc synthesis at the post-translational level. MdERF98, an apple ethylene response factor, whose transcription was modulated by Asc level, is directly bound to the promoter of MdGMP1 to promote the transcription of MdGMP1.

Literature:

Gene Resources:

  • NCBI ID:
  • UniProt accessions:

Sequences:

cDNA Sequence
mRNA Sequence
  • />MD15G1235900
    ATGGATGCAAAGAAGTTGAATGATTGTGGTATTTTTATGATTTGCAATGGCGGAAAGTTGGGTTTCTTGAGATTCGGGGATGAGAAATGGACCCATGTGGATGAACAAAACTCACATTATGATGATCTTATTGTGTATAAGGGTCAATGCTATGTTGTTGATAGATGGGGAACAGTTTCATGGGTCAATTCGGATTTGAATGTGATCCAATTTTCGCCTCCGTTATGTGGGTTTGGCGGGCGGAAGCATTTGGTTGAGTCCCTTGGCGATCTCTTCGTTGTTGATCGGTACCTTGACAAGTGTGAAATGGAAGGGTTACCAGAGCACAATGTTGAGAATGAAAATGTTAGTGTTTTTGGCCCTAATTTTCAAGCTCCTCCTCCTCCTTTCGCCGCTTCTGTTGACGGCAAGGCTGTTGATTTTAAAGTTTATAGGCTGGATCAAGAATGGGGTACGTGGGTTCAAATGAAAAACTTGGGAGATCAAGTGTTTATTTTGAGCAATGATGGGTCTTTCGCCGTCTCCACCAGAGACGTTGGTAGAGTGAAGGGAAATTGCATTTTATTCACTGATCAAAAGCTTCCTCATTTACACGGAATTGGGGGATCAAAAAGGCCTAACACTCGCGTGTTCATGCTAAAGGGTGACAGCATCATTCGGGACGGACATGCTTTGTCCGCCTTTAACAAAATGCTCCATCCACCATCCAGTTGGCTCCGCCCTGTTCTTGGTTTCCGTCGGCATCGGCTTGCTGACTGGGATAATGCTGACAGCGAGTGA
Protein Sequence
  • />MD15G1235900
    MDAKKLNDCGIFMICNGGKLGFLRFGDEKWTHVDEQNSHYDDLIVYKGQCYVVDRWGTVSWVNSDLNVIQFSPPLCGFGGRKHLVESLGDLFVVDRYLDKCEMEGLPEHNVENENVSVFGPNFQAPPPPFAASVDGKAVDFKVYRLDQEWGTWVQMKNLGDQVFILSNDGSFAVSTRDVGRVKGNCILFTDQKLPHLHGIGGSKRPNTRVFMLKGDSIIRDGHALSAFNKMLHPPSSWLRPVLGFRRHRLADWDNADSE