Gene Details:

Functional Descriptions:

  • MdRGL2a and MdCIPK20 were ubiquitinated and degraded by E3 ubiquitin ligases MdSINA1 and MdSINA2, respectively, both of which were activated in the presence of GA.
  • MdRGL2a and MdCIPK20 could be ubiquitinated and degraded by MdSINA1 and MdSINA2, respectively, via the proteasome pathway, which contributes to the negative effect of GA on anthocyanin accumulation.
  • Transient overexpression or silence of MdSINA2 results in decreased and increased accumulation of anthocyanin, respectively, in the peel of apple.
  • In addition, stable transformation assay in apple callus and Arabidopsis showed that MdSINA2 and MdCIPK20 antagonistically regulate anthocyanin accumulation.
  • The E3 ubiquitin ligases SINA1 and SINA2 integrate with the protein kinase CIPK20 to regulate the stability of RGL2a, a positive regulator of anthocyanin biosynthesis.

Literature:

Gene Resources:

  • NCBI ID:
  • UniProt accessions:

Orthologs:

Sequences:

cDNA Sequence
mRNA Sequence
  • />MD01G1218700
    TTTTTGGCTTAGGACAATAAAGCGGATTAAATAATTAACTCAATCCACAATAGCCGTCCGATTTCAATCCCACTCTCAATTACTTTTCGAATCAACGGCCACCCTTGTCCCTCTCTTTTTCTCTCTCCTCACTCAGACGAAGAGAGAGAGAGAGGGAGCGGAGAAGGAAAGAAAGAACCTTTTTTTCACAGAAGAGGGGGTTGGAATCCCATCAATCCATCTTCCCCCTCCTTCGCTCCCTCCTTTTTCTTCCACTCTCTGAAAATTTCCCGGAAAATAATAGGGAAGAAGGAAGGTCCGAGAGAAACCCAGCAGCTCCGAGCAATCGGTCCTTCGATTTATGGGTTCGCTTCGGGATTTTGATTAGTGGGTTTTGGATAAGTTTCCATTTTTTCAATTGGGTTTGGTGAAAACTTCGATCTTTTGGGGGTGTTCGAGGGGAAGAGCGATGGACTTGGAAAGCATCGAGTGTGTGTCGTCCTCAGATGGACTCGATGAGGACGAGATCCATCCCCACCACAACACTCTGCACCCGCATCCTCATCCTCATCAGCACCACCATGAATTTTCCAAGCCCAGAAGCAATGTCACCACCAACGCCACCATCAACGGGCCCACCGCCATTGCTCCCGCCACCAGCGTCCACGAGCTGCTCGAATGCCCCGTCTGCACCAATTCCATGTACCCGCCAATCCATCAGTGCCACAATGGCCACACACTCTGTTCCACTTGTAAATCGAGGGTACACAATCGCTGCCCCACTTGTAGACAGGAGCTTGGAGATATTAGGTGTTTAGCGCTGGAGAAGGTGGCCGAGTCACTTGAGTTACCCTGCAAGTATTACGCCTTGGGATGCCCAGAGATATTCCCGTACTACAGCAAACTAAAGCATGAATCGGTGTGCAACTTCAGACCGTACAATTGCCCTTATGCTGGATCGGAGTGCTCTGTTGTTGGAGACATCCCTTTCCTGGTTGCCCATCTAAGGGATGATCACAAGGTGGACATGCACACAGGATGCACATTCAACCATCGTTATGTGAAGTCAAATCCGCGGGAAGTAGAGAACGCCACATGGATGCTAACAGTCTTCCATTGTTTTGGTCAATACTTCTGCCTACATTTTGAAGCCTTCCAGCTCGGCATGGCTCCTGTTTATATGGCATTCCTACGTTTTATGGGCGACGAGAATGAGGCCCGGAATTACAGCTACAGCTTAGAGGTTGGAGCGAATGGCAGGAAACTCATATGGGAGGGGACACCACGAAGTGTCCGTGATAGCCACCGGAAGGTCAGGGATAGCCACGATGGTCTCATTATCCAACGAAACATGGCTCTGTTCTTCTCCGGAGGCGACAGGAAGGAGCTGAAGCTGAGAGTTACCGGGAGGATATGGAAGGAACAGCAAAATCAAGATTCTGGGGTGTGCATACCAAACCTGTGTAGCTAAGACAAATGATTTTGAAAACTTTAATGTTTGTTACTTGAGACACTGTCGTGTGTTGTTGTACCTGTGCCAGCTTCTTCCTGGTACGTTGTAACGAACCCGGTTTCTTGAGTTTGGGAAGTTTTCAGCTTTAATAAAATTGTATAATACGCAGGCGTTTTCTTCATTTTCAATTTGCTTGGTAACAATACAACTAGCATGCTTTTGAATCAAGACAATTCCAATAAGCCTCAATGCCATAAACCCACTAATTCCAACTGAGAAAAACGATCTATCACAAATTTTCACCAGTTACCCAAATTCAAACCGATACCTGCTCAGTTGCGCCGTCACTTTTGGACTCTATCTCAGCTGAGCCTTGGCCTTCTTCTCCGCTACGTTCCTCCTGACCAGTCTGTGCAGCTTCACT
Protein Sequence
  • />MD01G1218700
    MDLESIECVSSSDGLDEDEIHPHHNTLHPHPHPHQHHHEFSKPRSNVTTNATINGPTAIAPATSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKSRVHNRCPTCRQELGDIRCLALEKVAESLELPCKYYALGCPEIFPYYSKLKHESVCNFRPYNCPYAGSECSVVGDIPFLVAHLRDDHKVDMHTGCTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMAPVYMAFLRFMGDENEARNYSYSLEVGANGRKLIWEGTPRSVRDSHRKVRDSHDGLIIQRNMALFFSGGDRKELKLRVTGRIWKEQQNQDSGVCIPNLCS