Gene Details:

Functional Descriptions:

  • MdRGL2a and MdCIPK20 were ubiquitinated and degraded by E3 ubiquitin ligases MdSINA1 and MdSINA2, respectively, both of which were activated in the presence of GA.
  • MdSINA1 mediates ubiquitination and degradation of MdRGL2a via the 26S proteasome pathway.
  • In MdRGL2a-overexpressing apple callus, overexpression of MdSINA1 caused a significant decrease in anthocyanin accumulation, while silencing of MdSINA1 resulted in a significant increase in anthocyanin accumulation.
  • These results suggested that MdSINA1 interacts with and antagonizes MdRGL2a in the regulation of anthocyanin accumulation.
  • The E3 ubiquitin ligases SINA1 and SINA2 integrate with the protein kinase CIPK20 to regulate the stability of RGL2a, a positive regulator of anthocyanin biosynthesis.
  • The E3 ubiquitin ligase SINA1 and the protein kinase BIN2 cooperatively regulate PHR1 in apple anthocyanin biosynthesis.

Literature:

Gene Resources:

  • NCBI ID:
  • UniProt accessions:

Orthologs:

Sequences:

cDNA Sequence
mRNA Sequence
  • />MD01G1082000
    TATTCTATTAACCTACCAATCAAAACCCTTAACTGAATCTTTAACGGGCATTTGATACCCGTCTGATCTTAATCAGACGGCTGATATCATCGGGAAGGTGACCCATCTCTTTCTCTCTCTATCTGTAAACCAACGATGAAGAAGCACCCCTTTTGCGAAAAAACAAAATAAAATTTTGGGTTTCATCGCACAATGCATTCCAAAATTTTCGTTATTTTCCCTTCCAATTTTCTATTCGTTTTTGTATAATTGCGTATTGGGGAATCATACCCATCAGTCAAAGAATCGAAAGATTTCATCTTTTTCCCTAAATTTTTGGTGGTGGGGGTTTGTTTCCATTGAAGAATGGAATCAGACATCATTGAAAGTCTTGCGTCTTTGGATTTGATTGACGATGATGAGATCCATGGCCGTCCGATTCATCAATTTGTTTCAGTTCCGAAGGCGCACAGCAACACCGGCAATAACATTCCCGGCACCACCAGCGTCCACGAGCTTCTTGAATGCCCTGTTTGCACCAATTCAATGTACCCTCCAATCCATCAGTGTCACAATGGGCATACCCTTTGTTCCACCTGTAAAGCAAGGGTGCATAATCGGTGCCCAACGTGTAGACAGGAGCTTGGTGACATAAGGTGTCTAGCACTGGAGAAGGTTGCTGAATCGCTTGAACTGCCCTGCAAGTATTGCTCTCTTGGGTGCTCAGAGATATTTCCCTATTATAGTAAACTGAAACACGAGGCTGTCTGTAACTTCAGACCATACAACTGTCCATATGCTGGATCAGACTGCTCCGCTGTTGGGGATATTCCATTCCTTGTTTCTCATCTCCGGGATGATCACAAGGTGGACATGCATTCCGGATGCACTTTTAATCATCGTTATGTAAAGTCTAATCCTCGTGAAGTAGAAAATGCCACGTGGATGTTAACTGTCTTCCACTGTTTTGGTCAGTACTTCTGTCTACATTTTGAAGCCTTCCAGCTTGGTATGGCCCCCGTTTACATGGCATTTCTCCGGTTCATGGGGGATGAAACAGAAGCTCGGAATTACAGCTACAGCTTGGAGGTTGGTGGAAATGGCCGAAAGCTGATTTGGGAGGGCAACCCAAGAAGCATAAGGGATAGCCACAAGAAGGTTAGAGACAGCCATGATGGCCTCATAATACAGCGCAACATGGCACTTTTCTTCTCTGGCGGGGATAGGAAAGAGCTGAAGCTGCGGGTCACGGGACGGATATGGAAGGAACAGCAGAACCCAGAAGGGGCGAAGGTTTGTGAAGTAATGCGTACGATTGCGGTTTAGACAGATTGATAAAGAAGTTGGTGAGACATCTGGAGCTTGGGGTTTCAGTTTATTTACTTGGTAGTGTTGAAGTATGTATCAATGTCAAATATATAAACCATAAGCTTTTTCATCCTATGATCTACAAGTACTCAACAGGGAAATCACTCCTTTACTTGTCTTGGAATTACTCTACTTTATTTGATGTACCAAGCTCAACGTTGAATCAAATGATACCTAAACAAGTTGATCGGTGAGGAGTCATCGTTTCATCCATCGTGTTTGCTATGAGTCGGGGGCAAAACTGGAGATAAGATGGGCAATCTTTAAGTCTCTCCAGCCCTCAGCCGGATCAGAAACAAAGGACCACTCGCTCTTGCATCCTTTGGTGGTTGCCATTGCGGTCGTTGATGGCTCATGATCATCTGATGATGCTACTGTGCAGTAATGGACCGGATGGGGTTCGCCGGGGACTCCTCTATTCCGAGAGTGTTTTCCTTGCCATTTTGATGATTCTGTGTTTCTTTTCCATGAGAGGTTGAGAGAAACAAGAAAAAGGAACTTGAAATGTCTGTACGTCTCTGTGAGGTTTGAATTTGTATCTTTTTGCTGGAGCACACTAGGCTTGTTAAACAGATCACAAACATTTCAAATTAGGTCACAACTTTCATGATATTCGGACTCAAATCATTTTTAAATTTCGATTTGTAATAATACCAAAGGCTCACATTTCTCTTTTGCTTGTAAGTGAGAGGCTTTTAAGTTCAATTC
Protein Sequence
  • />MD01G1082000
    MESDIIESLASLDLIDDDEIHGRPIHQFVSVPKAHSNTGNNIPGTTSVHELLECPVCTNSMYPPIHQCHNGHTLCSTCKARVHNRCPTCRQELGDIRCLALEKVAESLELPCKYCSLGCSEIFPYYSKLKHEAVCNFRPYNCPYAGSDCSAVGDIPFLVSHLRDDHKVDMHSGCTFNHRYVKSNPREVENATWMLTVFHCFGQYFCLHFEAFQLGMAPVYMAFLRFMGDETEARNYSYSLEVGGNGRKLIWEGNPRSIRDSHKKVRDSHDGLIIQRNMALFFSGGDRKELKLRVTGRIWKEQQNPEGAKVCEVMRTIAV