Gene Details:

• Gene ID: CotAD_21502
• Gene Symbol: GhMKK6
• Gene Name: mitogen-activated protein kinase 6
• Genome: TM1_NBI
• Species: Gossypium hirsutum

Functional Descriptions:

• Scaffold protein GhMORG1 enhances the resistance of cotton to Fusarium oxysporum by facilitating the GhMKK6-GhMPK4 cascade.
• GhMORG1 interacted with GhMKK6 and GhMPK4, and the overexpression of GhMORG1 in cotton protoplasts dramatically increased the activity of the GhMKK6-GhMPK4 cascade.
• Identified as putative substrates of the GhMORG1-dependent GhMKK6-GhMPK4 cascade and participated in the resistance of cotton to F. oxysporum.
• Ghr-miR5272a-mediated regulation of GhMKK6 gene transcription contributes to the immune response in cotton.
• These results indicated that GhMORG1 regulated the resistance of cotton to F. oxysporum by mediating the GhMKK6-GhMPK4 cascade.
• These results suggest that GhMORG1 regulates several different disease resistance processes by facilitating the phosphorylation of GhMKK6-GhMPK4 cascade substrates. Taken together, these findings reveal a new plant MAPK scaffold protein and provide insights into the mechanism of plant resistance to pathogens.

Function-related keywords:

• resistance ,  disease ,  disease-resistance ,  immune-response ,  protoplasts ,  protein

Literature:

• Scaffold protein GhMORG1 enhances the resistance of cotton to Fusarium oxysporum by facilitating the MKK6-MPK4 cascade.   DOI:  10.1111/pbi.13307 ;  PMID:  31794094
• ghr-miR5272a-mediated regulation of GhMKK6 gene transcription contributes to the immune response in cotton.   DOI:  10.1093/jxb/erx373 ;  PMID:  29069454

Related News:

Gene Resources:

• NCBI ID: GU188977.1
• UniProt accessions:

Orthologs:

Sequences: