Gene Details:

• Gene ID: Csa_5G623470
• Gene Symbol: CsMLO8
• Gene Name: Mildew Resistance Locus O8
• Genome: Cucumis sativus ASM407v2
• Species: Cucumis sativus

Functional Descriptions:

• The reverse mutation of CsMLO8 results in susceptibility to powdery mildew via inhibiting cell wall apposition formation and cell death in cucumber.
• The resistant line contains a transposon in susceptibility gene CsMLO8, causing alternative splicing and loss of function of the gene.
• Results showed that the loss of function of CsMLO8 mediated resistance to powdery mildew was related to cell wall apposition formation and cell death.
• The CsMLO8 revertant (m6326) showed a higher rate of spore penetration, longer hypha and more conidia.
• CsMLO8/CsMLO11 are required for full susceptibility of cucumber stem to powdery mildew and interact with CsCRK2 and CsRbohDCsMLO8/11 are required for full susceptibility of cucumber stem to powdery mildew and interact with CsCRK2 and CsRbohD.

Function-related keywords:

• stem ,  resistance ,  cell-death ,  cell-wall ,  resistant ,  powdery-mildew ,  mildew-resistance ,  mildew ,  powdery-mildew-resistance

Literature:

• CsMLO8/11 are required for full susceptibility of cucumber stem to powdery mildew and interact with CsCRK2 and CsRbohD.   DOI:  10.1093/hr/uhad295 ;  PMID:  38404593
• The reverse mutation of CsMLO8 results in susceptibility to powdery mildew via inhibiting cell wall apposition formation and cell death in cucumber (Cucumis sativus L.).   DOI:  10.1016/j.scienta.2023.111894

Related News:

Gene Resources:

• NCBI ID: 101218929
• UniProt accessions: A0A0A0KRN4

Orthologs:

Sequences: