Gene Details:

• Gene ID: AT5G44070
• Gene Symbol: ARA8, ATPCS1, CAD1, PCS1
• Gene Name: ARABIDOPSIS THALIANA PHYTOCHELATIN SYNTHASE 1, CADMIUM SENSITIVE 1, PHYTOCHELATIN SYNTHASE 1
• Description: phytochelatin synthase 1 (PCS1);(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G44070.1     AT5G44070.2

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009047  — stem — caña (Spanish, exact), culm (exact), eje primario (Spanish, exact), primary axis (exact), primary stem (exact), tallo (Spanish, exact), tronco (Spanish, exact), 茎 (Japanese, exact), bole (narrow), cane (narrow), caudex (narrow), caudices (narrow), core (narrow), primocane (narrow), scape (narrow), stalk (narrow), trunk (narrow)
• PO:0000084  — plant sperm cell — célula espermática o esperma (Spanish, exact), male gamete (exact), microgamete (exact), 植物精子細胞 (Japanese, exact), sperm nucleus (related), sperm cell (broad)

Function-related keywords:

• root ,  shoot system ,  vascular leaf ,  flower ,  stem ,  root ,  plant sperm cell

Literature:

• Molecular characterisation and expression of a wound-inducible cDNA encoding a novel cinnamyl-alcohol dehydrogenase enzyme in lucerne (Medicago sativa L.).   DOI:  10.1023/a:1006381630494 ;  PMID:  10579494
• Long-distance root-to-shoot transport of phytochelatins and cadmium in Arabidopsis.   DOI:  10.1073/pnas.1734072100 ;  PMID:  12909714
• Expression of Arabidopsis phytochelatin synthase 2 is too low to complement an AtPCS1-defective Cad1-3 mutant.   DOI:  S1016-8478(23)13140-2 ;  PMID:  15750344
• Arabidopsis thaliana expresses a second functional phytochelatin synthase.   DOI:  10.1016/s0014-5793(01)02976-3 ;  PMID:  11684101
• Function of phytochelatin synthase in catabolism of glutathione-conjugates.   DOI:  10.1111/j.1365-313X.2006.02993.x ;  PMID:  17253989
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Glucosinolate metabolites required for an Arabidopsis innate immune response.   DOI:  10.1126/science.1164627 ;  PMID:  19095898
• HMA P-type ATPases are the major mechanism for root-to-shoot Cd translocation in Arabidopsis thaliana.   DOI:  10.1111/j.1469-8137.2008.02638.x ;  PMID:  19076718
• Cytosolic action of phytochelatin synthase.   DOI:  10.1104/pp.109.149922 ;  PMID:  20304971
• Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters.   DOI:  10.1073/pnas.1013964107 ;  PMID:  21078981
• Glutathione-indole-3-acetonitrile is required for camalexin biosynthesis in Arabidopsis thaliana.   DOI:  10.1105/tpc.110.079145 ;  PMID:  21239642
• Isolation and characterization of Arabidopsis halleri and Thlaspi caerulescens phytochelatin synthases.   DOI:  10.1007/s00425-011-1378-z ;  PMID:  21369921
• In silico and in vivo studies of an Arabidopsis thaliana gene, ACR2, putatively involved in arsenic accumulation in plants.   DOI:  10.1007/s00894-012-1419-y ;  PMID:  22562211
• Arabidopsis NRT1.5 is another essential component in the regulation of nitrate reallocation and stress tolerance.   DOI:  10.1104/pp.112.199257 ;  PMID:  22685171
• Mutants impaired in vacuolar metal mobilization identify chloroplasts as a target for cadmium hypersensitivity in Arabidopsis thaliana.   DOI:  10.1111/pce.12016 ;  PMID:  22998565
• Correlation between hormonal homeostasis and morphogenic responses in Arabidopsis thaliana seedlings growing in a Cd/Cu/Zn multi-pollution context.   DOI:  10.1111/ppl.12050 ;  PMID:  23496095
• Arabidopsis thaliana phytochelatin synthase 2 is constitutively active in vivo and can rescue the growth defect of the PCS1-deficient cad1-3 mutant on Cd-contaminated soil.   DOI:  10.1093/jxb/eru195 ;  PMID:  24821959
• An eukaryotic translation initiation factor, AteIF5A-2, affects cadmium accumulation and sensitivity in Arabidopsis.   DOI:  10.1111/jipb.12329 ;  PMID:  25559189
• Endogenous Arabidopsis messenger RNAs transported to distant tissues.   DOI:  10.1038/nplants.2015.25 ;  PMID:  27247031
• Zinc-Finger Transcription Factor ZAT6 Positively Regulates Cadmium Tolerance through the Glutathione-Dependent Pathway in Arabidopsis.   DOI:  10.1104/pp.15.01882 ;  PMID:  26983992
• An emphasis of hydrogen sulfide-cysteine cycle on enhancing the tolerance to chromium stress in Arabidopsis.   DOI:  10.1016/j.envpol.2016.03.035 ;  PMID:  27038574
• A role for APX1 gene in lead tolerance in Arabidopsis thaliana.   DOI:  10.1016/j.plantsci.2016.11.015 ;  PMID:  28167043
• Dissecting the components controlling root-to-shoot arsenic translocation in Arabidopsis thaliana.   DOI:  10.1111/nph.14761 ;  PMID:  28857170
• Identification of C-terminal Regions in Arabidopsis thaliana Phytochelatin Synthase 1 Specifically Involved in Activation by Arsenite.   DOI:  10.1093/pcp/pcx204 ;  PMID:  29281059
• WRKY12 represses GSH1 expression to negatively regulate cadmium tolerance in Arabidopsis.   DOI:  10.1007/s11103-018-0809-7 ;  PMID:  30617455
• A substrate of the ABC transporter PEN3 stimulates bacterial flagellin (flg22)-induced callose deposition in Arabidopsis thaliana.   DOI:  10.1074/jbc.RA119.007676 ;  PMID:  30833326
• A plant genetic network for preventing dysbiosis in the phyllosphere.   DOI:  10.1038/s41586-020-2185-0 ;  PMID:  32350464
• MYB4 transcription factor, a member of R2R3-subfamily of MYB domain protein, regulates cadmium tolerance via enhanced protection against oxidative damage and increases expression of PCS1 and MT1C in Arabidopsis.   DOI:  10.1016/j.plantsci.2020.110501 ;  PMID:  32563471
• A MYB4-MAN3-Mannose-MNB1 signaling cascade regulates cadmium tolerance in Arabidopsis.   DOI:  10.1371/journal.pgen.1009636 ;  PMID:  34181654
• The transcription factor MYB40 is a central regulator in arsenic resistance in Arabidopsis.   DOI:  10.1016/j.xplc.2021.100234 ;  PMID:  34778748
• Phytochelatin-mediated metal detoxification pathway is crucial for an organomercurial phenylmercury tolerance in Arabidopsis.   DOI:  10.1007/s11103-021-01221-0 ;  PMID:  34837578
• Transcription factor ANAC004 enhances Cd tolerance in Arabidopsis thaliana by regulating cell wall fixation, translocation and vacuolar detoxification of Cd, ABA accumulation and antioxidant capacity.   DOI:  10.1016/j.jhazmat.2022.129121 ;  PMID:  35580499
• AIG2A and AIG2B limit the activation of salicylic acid-regulated defenses by tryptophan-derived secondary metabolism in Arabidopsis.   DOI:  10.1093/plcell/koac255 ;  PMID:  35972413
• and phytochelatin synthase-mediated catabolism of glutathione and glutathione S-conjugates in Arabidopsis thaliana.   DOI:  10.5511/plantbiotechnology.22.1003a ;  PMID:  37283618
• Analysis of protein complexes in Arabidopsis leaves using size exclusion chromatography and label-free protein correlation profiling.   DOI:  10.1016/j.jprot.2017.06.004 ;  PMID:  28627464

Sequences: