Gene Details:

• Gene ID: AT5G42540
• Gene Symbol: AtXRN2, XRN2
• Gene Name: EXORIBONUCLEASE 2, exoribonuclease 2
• Description: exoribonuclease 2;(source:Araport11)
• TAIR Accession: locus:2152676
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G42540.1     AT5G42540.2

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009047  — stem — caña (Spanish, exact), culm (exact), eje primario (Spanish, exact), primary axis (exact), primary stem (exact), tallo (Spanish, exact), tronco (Spanish, exact), 茎 (Japanese, exact), bole (narrow), cane (narrow), caudex (narrow), caudices (narrow), core (narrow), primocane (narrow), scape (narrow), stalk (narrow), trunk (narrow)

Gene Ontology:

• GO:0004534  — enables — 5-3 RNA exonuclease activity
• GO:0010587  — acts upstream of or within — miRNA catabolic process
• GO:0003723  — enables — RNA binding
• GO:0005634  — located in — nucleus
• GO:0005634  — is active in — nucleus
• GO:0000967  — involved in — rRNA 5-end processing GO:0000967 29422 P other cellular processes IMP none Publication:501736341|PMID:20338880 2021-03-31 AT5G42540 locus:2152676 AT5G42540 involved in nuclear polyadenylation-dependent rRNA catabolic process GO:0071035 32918 P other cellular processes IMP none Publication:501736341|PMID:20338880 2021-03-31 AT5G42540 locus:2152676 AT5G42540 acts upstream of or within miRNA catabolic process GO:0010587 29498 P other cellular processes IMP analysis of visible trait NONE Publication:501723596|PMID:17993620 TAIR 2008-08-22 AT5G42540 locus:2152676 AT5G42540 involved in nuclear-transcribed mRNA catabolic process GO:0000956 29411 P nucleobase-containing compound metabolic process IBA none PANTHER:PTN002643517|TAIR:locus:2020073|FB:FBgn0020261|SGD:S000003141|SGD:S000005574|UniProtKB:Q8IZH2|PomBase:SPAC26A3.12c Communication:501741973 2023-06-07 AT5G42540 locus:2152676 AT5G42540 enables 5-3 RNA exonuclease activity GO:0004534 853 F catalytic activity IGI Functional complementation in heterologous system Publication:1346012|PMID:11106401 TAIR 2008-04-04 AT5G42540 locus:2152676 AT5G42540 involved in miRNA catabolic process GO:0010587 29498 P nucleobase-containing compound metabolic process IMP none Publication:501723596|PMID:17993620 2021-03-31 AT5G42540 locus:2152676 AT5G42540 located in nucleus GO:0005634 537 C nucleus IMP none Publication:501736341|PMID:20338880 2017-07-02 AT5G42540 locus:2152676 AT5G42540 enables zinc ion binding GO:0008270 4661 F other binding IEA none InterPro:IPR001878|InterPro:IPR036875 AnalysisReference:501756966 2023-06-11 AT5G42540 locus:2152676 AT5G42540 enables 5-3 RNA exonuclease activity GO:0004534 853 F nuclease activity IBA none PANTHER:PTN002643517|WB:WBGene00006964|UniProtKB:Q9FQ02|PomBase:SPAC26A3.12c|PomBase:SPAC17A5.14|UniProtKB:Q8IZH2|CGD:CAL0000180194|SGD:S000003141|TAIR:locus:2020073|MGI:MGI:891964|SGD:S000005574|TAIR:locus:2005614|CGD:CAL0000192354|FB:FBgn0031868 Communication:501741973 2023-06-07 AT5G42540 locus:2152676 AT5G42540 involved in miRNA catabolic process GO:0010587 29498 P catabolic process IMP none Publication:501723596|PMID:17993620 2021-03-31 AT5G42540 locus:2152676 AT5G42540 enables 5-3 RNA exonuclease activity GO:0004534 853 F catalytic activity IDA none Publication:1346012|PMID:11106401 2021-04-01 AT5G42540 locus:2152676 AT5G42540 involved in nuclear-transcribed mRNA catabolic process GO:0000956 29411 P other cellular processes IBA none PANTHER:PTN002643517|TAIR:locus:2020073|FB:FBgn0020261|SGD:S000003141|SGD:S000005574|UniProtKB:Q8IZH2|PomBase:SPAC26A3.12c Communication:501741973 2023-06-07 AT5G42540 locus:2152676 AT5G42540 involved in nuclear-transcribed mRNA catabolic process GO:0000956 29411 P catabolic process IBA none PANTHER:PTN002643517|TAIR:locus:2020073|FB:FBgn0020261|SGD:S000003141|SGD:S000005574|UniProtKB:Q8IZH2|PomBase:SPAC26A3.12c Communication:501741973 2023-06-07 AT5G42540 locus:2152676 AT5G42540 involved in nuclear-transcribed mRNA catabolic process GO:0000956 29411 P other metabolic processes IBA none PANTHER:PTN002643517|TAIR:locus:2020073|FB:FBgn0020261|SGD:S000003141|SGD:S000005574|UniProtKB:Q8IZH2|PomBase:SPAC26A3.12c Communication:501741973 2023-06-07 AT5G42540 locus:2152676 AT5G42540 involved in rRNA 5-end processing
• GO:0071035  — involved in — nuclear polyadenylation-dependent rRNA catabolic process
• GO:0003676  — enables — nucleic acid binding
• GO:0060149  — involved in — negative regulation of post-transcriptional gene silencing
• GO:0010587  — involved in — miRNA catabolic process

Function-related keywords:

• root ,  vascular leaf ,  flower ,  stem ,  root

Literature:

• Novel features of the XRN-family in Arabidopsis: evidence that AtXRN4, one of several orthologs of nuclear Xrn2p/Rat1p, functions in the cytoplasm.   DOI:  10.1073/pnas.97.25.13985 ;  PMID:  11106401
• Arabidopsis FIERY1, XRN2, and XRN3 are endogenous RNA silencing suppressors.   DOI:  10.1105/tpc.107.055319 ;  PMID:  17993620
• Arabidopsis thaliana XRN2 is required for primary cleavage in the pre-ribosomal RNA.   DOI:  10.1093/nar/gkq172 ;  PMID:  20338880
• The bifunctional abiotic stress signalling regulator and endogenous RNA silencing suppressor FIERY1 is required for lateral root formation.   DOI:  10.1111/j.1365-3040.2010.02218.x ;  PMID:  20807376
• The second face of a known player: Arabidopsis silencing suppressor AtXRN4 acts organ-specifically.   DOI:  10.1111/j.1469-8137.2010.03482.x ;  PMID:  21039560
• Surveillance of 3' Noncoding Transcripts Requires FIERY1 and XRN3 in Arabidopsis.   DOI:  10.1534/g3.111.001362 ;  PMID:  22540040
• atBRX1-1 and atBRX1-2 are involved in an alternative rRNA processing pathway in Arabidopsis thaliana.   DOI:  10.1261/rna.047563.114 ;  PMID:  25605960
• The Nuclear Ribonucleoprotein SmD1 Interplays with Splicing, RNA Quality Control, and Posttranscriptional Gene Silencing in Arabidopsis.   DOI:  10.1105/tpc.15.01045 ;  PMID:  26842463
• Activity and roles of Arabidopsis thaliana XRN family exoribonucleases in noncoding RNA pathways.   DOI:  10.1007/s10265-016-0887-z ;  PMID:  27988817
• Defective XRN3-mediated transcription termination in Arabidopsis affects the expression of protein-coding genes.   DOI:  10.1111/tpj.13826 ;  PMID:  29356198
• FIERY1 promotes microRNA accumulation by suppressing rRNA-derived small interfering RNAs in Arabidopsis.   DOI:  10.1038/s41467-019-12379-z ;  PMID:  31562313
• AtXRN4 Affects the Turnover of Chosen miRNA*s in Arabidopsis.   DOI:  10.3390/plants9030362 ;  PMID:  32182993
• XRN2 suppresses aberrant entry of tRNA trailers into argonaute in humans and Arabidopsis.   DOI:  10.1371/journal.pgen.1010755 ;  PMID:  37146074

Sequences: