Gene Details:

• Gene ID: AT5G41315
• Gene Symbol: GL3, GL3, MYC6.2
• Gene Name: GLABRA 3, GLABROUS 3
• Description: basic helix-loop-helix (bHLH) DNA-binding superfamily protein;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G41315.1     AT5G41315.2     AT5G41315.3

Plant Ontology Annotations:

• PO:0000263  — non-hair root epidermal cell — atrichoblast (exact), atricoblasto (Spanish, exact), 非毛根形成細胞、アトリコブラスト (Japanese, exact), non-hair cell (broad)

Function-related keywords:

• non-hair root epidermal cell

Literature:

• Genetic control of trichome branch number in Arabidopsis: the roles of the FURCA loci.   DOI:  10.1242/dev.126.24.5547 ;  PMID:  10572032
• A model for cell-type determination and differentiation in plants.   DOI:  NA ;  PMID:  1843415
• Overexpression of the AtmybL2 gene represses trichome development in Arabidopsis.   DOI:  10.1093/dnares/9.2.31 ;  PMID:  12056412
• Cell-fate specification in the epidermis: a common patterning mechanism in the root and shoot.   DOI:  10.1016/s136952660200002x ;  PMID:  12495754
• The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.   DOI:  10.1093/molbev/msg088 ;  PMID:  12679534
• A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis.   DOI:  10.1242/dev.00681 ;  PMID:  12917293
• The bHLH genes GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) specify epidermal cell fate in the Arabidopsis root.   DOI:  10.1242/dev.00880 ;  PMID:  14627722
• The bHLH genes GL3 and EGL3 participate in an intercellular regulatory circuit that controls cell patterning in the Arabidopsis root epidermis.   DOI:  10.1242/dev.01565 ;  PMID:  15590742
• Epidermal cell patterning and differentiation throughout the apical-basal axis of the seedling.   DOI:  10.1093/jxb/eri213 ;  PMID:  15967776
• Positional information and mobile transcriptional regulators determine cell pattern in the Arabidopsis root epidermis.   DOI:  10.1093/jxb/erj037 ;  PMID:  16317033
• TT8 controls its own expression in a feedback regulation involving TTG1 and homologous MYB and bHLH factors, allowing a strong and cell-specific accumulation of flavonoids in Arabidopsis thaliana.   DOI:  10.1111/j.1365-313X.2006.02733.x ;  PMID:  16709193
• Nitrogen deficiency enhances expression of specific MYB and bHLH transcription factors and accumulation of end products in the flavonoid pathway.   DOI:  10.1007/s00425-006-0414-x ;  PMID:  17053893
• Functional analysis of the epidermal-specific MYB genes CAPRICE and WEREWOLF in Arabidopsis.   DOI:  10.1105/tpc.106.045732 ;  PMID:  17644729
• Expression analysis of anthocyanin regulatory genes in response to different light qualities in Arabidopsis thaliana.   DOI:  10.1016/j.jplph.2007.06.010 ;  PMID:  17766004
• Participation of the Arabidopsis bHLH factor GL3 in trichome initiation regulatory events.   DOI:  10.1104/pp.107.104521 ;  PMID:  17885086
• Nutrient depletion as a key factor for manipulating gene expression and product formation in different branches of the flavonoid pathway.   DOI:  10.1111/j.1365-3040.2007.01748.x ;  PMID:  18031469
• Salt-induced plasticity of root hair development is caused by ion disequilibrium in Arabidopsis thaliana.   DOI:  10.1007/s10265-007-0123-y ;  PMID:  18060349
• The TTG1-bHLH-MYB complex controls trichome cell fate and patterning through direct targeting of regulatory loci.   DOI:  10.1242/dev.016873 ;  PMID:  18434419
• Comprehensive analysis of single-repeat R3 MYB proteins in epidermal cell patterning and their transcriptional regulation in Arabidopsis.   DOI:  10.1186/1471-2229-8-81 ;  PMID:  18644155
• Quantitative analysis of heterogeneous spatial distribution of Arabidopsis leaf trichomes using micro X-ray computed tomography.   DOI:  10.1111/j.1365-313X.2008.03609.x ;  PMID:  18643999
• A mutual support mechanism through intercellular movement of CAPRICE and GLABRA3 can pattern the Arabidopsis root epidermis.   DOI:  10.1371/journal.pbio.0060235 ;  PMID:  18816165
• Arabidopsis transient expression analysis reveals that activation of GLABRA2 may require concurrent binding of GLABRA1 and GLABRA3 to the promoter of GLABRA2.   DOI:  10.1093/pcp/pcn159 ;  PMID:  18948276
• Jasmonic acid control of GLABRA3 links inducible defense and trichome patterning in Arabidopsis.   DOI:  10.1242/dev.030585 ;  PMID:  19234066
• SAD2 in Arabidopsis functions in trichome initiation through mediating GL3 function and regulating GL1, TTG1 and GL2 expression.   DOI:  10.1111/j.1744-7909.2008.00695.x ;  PMID:  18713401
• BHLH32 modulates several biochemical and morphological processes that respond to Pi starvation in Arabidopsis.   DOI:  10.1042/BJ20070102 ;  PMID:  17376028
• Temperature and nitrogen effects on regulators and products of the flavonoid pathway: experimental and kinetic model studies.   DOI:  10.1111/j.1365-3040.2008.01920.x ;  PMID:  19054348
• Functional diversity of R3 single-repeat genes in trichome development.   DOI:  10.1242/dev.021733 ;  PMID:  19336467
• The endogenous GL3, but not EGL3, gene is necessary for anthocyanin accumulation as induced by nitrogen depletion in Arabidopsis rosette stage leaves.   DOI:  10.1007/s00425-009-0978-3 ;  PMID:  19621239
• The GLABRA2 homeodomain protein directly regulates CESA5 and XTH17 gene expression in Arabidopsis roots.   DOI:  10.1111/j.1365-313X.2009.03976.x ;  PMID:  19619157
• Molecular mechanism for jasmonate-induction of anthocyanin accumulation in Arabidopsis.   DOI:  10.1093/jxb/erp223 ;  PMID:  19596700
• Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.   DOI:  10.1016/j.diff.2010.02.003 ;  PMID:  20219281
• Ethylene suppression of sugar-induced anthocyanin pigmentation in Arabidopsis.   DOI:  10.1104/pp.110.161869 ;  PMID:  20876338
• Analysis of purified glabra3-shapeshifter trichomes reveals a role for NOECK in regulating early trichome morphogenic events.   DOI:  10.1111/j.1365-313X.2010.04329.x ;  PMID:  21070410
• Auxin modulates the enhanced development of root hairs in Arabidopsis thaliana (L.) Heynh. under elevated CO(2).   DOI:  10.1111/j.1365-3040.2011.02330.x ;  PMID:  21477123
• The Jasmonate-ZIM-domain proteins interact with the WD-Repeat/bHLH/MYB complexes to regulate Jasmonate-mediated anthocyanin accumulation and trichome initiation in Arabidopsis thaliana.   DOI:  10.1105/tpc.111.083261 ;  PMID:  21551388
• Brassinosteroid enhances jasmonate-induced anthocyanin accumulation in Arabidopsis seedlings.   DOI:  10.1111/j.1744-7909.2011.01042.x ;  PMID:  21545406
• Cell fate in the Arabidopsis root epidermis is determined by competition between WEREWOLF and CAPRICE.   DOI:  10.1104/pp.111.185785 ;  PMID:  21914815
• Analysis of IIId, IIIe and IVa group basic-helix-loop-helix proteins expressed in Arabidopsis root epidermis.   DOI:  10.1016/j.plantsci.2011.07.006 ;  PMID:  21889054
• Functional characterization of TRICHOMELESS2, a new single-repeat R3 MYB transcription factor in the regulation of trichome patterning in Arabidopsis.   DOI:  10.1186/1471-2229-11-176 ;  PMID:  22168948
• Zinc finger protein5 is required for the control of trichome initiation by acting upstream of zinc finger protein8 in Arabidopsis.   DOI:  10.1104/pp.111.180281 ;  PMID:  21803862
• A single amino acid substitution in IIIf subfamily of basic helix-loop-helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis.   DOI:  10.1074/jbc.M111.280735 ;  PMID:  22334670
• Characterization of the regulatory network of BoMYB2 in controlling anthocyanin biosynthesis in purple cauliflower.   DOI:  10.1007/s00425-012-1665-3 ;  PMID:  22644767
• Control of plant trichome and root-hair development by a tomato (Solanum lycopersicum) R3 MYB transcription factor.   DOI:  10.1371/journal.pone.0054019 ;  PMID:  23326563
• Ubiquitin protein ligase 3 mediates the proteasomal degradation of GLABROUS 3 and ENHANCER OF GLABROUS 3, regulators of trichome development and flavonoid biosynthesis in Arabidopsis.   DOI:  10.1111/tpj.12132 ;  PMID:  23373825
• Zinc Finger Protein 6 (ZFP6) regulates trichome initiation by integrating gibberellin and cytokinin signaling in Arabidopsis thaliana.   DOI:  10.1111/nph.12211 ;  PMID:  23506479
• Modified bimolecular fluorescence complementation assay to study the inhibition of transcription complex formation by JAZ proteins.   DOI:  10.1007/978-1-62703-414-2_15 ;  PMID:  23615997
• Tomato (Solanum lycopersicum) homologs of TRIPTYCHON (SlTRY) and GLABRA3 (SlGL3) are involved in anthocyanin accumulation.   DOI:  10.4161/psb.24575 ;  PMID:  23603939
• Identification and characterization of cotton genes involved in fuzz-fiber development.   DOI:  10.1111/jipb.12072 ;  PMID:  23710824
• Mutual control of intracellular localisation of the patterning proteins AtMYC1, GL1 and TRY/CPC in Arabidopsis.   DOI:  10.1242/dev.094698 ;  PMID:  23900543
• Regulation of anthocyanin biosynthesis in Arabidopsis thaliana red pap1-D cells metabolically programmed by auxins.   DOI:  10.1007/s00425-013-2011-0 ;  PMID:  24370633
• Arabidopsis DELLA and JAZ proteins bind the WD-repeat/bHLH/MYB complex to modulate gibberellin and jasmonate signaling synergy.   DOI:  10.1105/tpc.113.121731 ;  PMID:  24659329
• Comparison of five major trichome regulatory genes in Brassica villosa with orthologues within the Brassicaceae.   DOI:  10.1371/journal.pone.0095877 ;  PMID:  24755905
• Arabidopsis TTG2 regulates TRY expression through enhancement of activator complex-triggered activation.   DOI:  10.1105/tpc.114.129379 ;  PMID:  25304203
• Expression of PRX36, PMEI6 and SBT1.7 is controlled by complex transcription factor regulatory networks for proper seed coat mucilage extrusion.   DOI:  10.4161/15592324.2014.977734 ;  PMID:  25531128
• RPN1a, a subunit of the 26S proteasome, controls trichome development in Arabidopsis.   DOI:  10.1016/j.plaphy.2015.01.012 ;  PMID:  25676129
• Analysis of interactions between heterologously produced bHLH and MYB proteins that regulate anthocyanin biosynthesis: quantitative interaction kinetics by Microscale Thermophoresis.   DOI:  10.1016/j.phytochem.2015.01.004 ;  PMID:  25659750
• GLABROUS INFLORESCENCE STEMS3 (GIS3) regulates trichome initiation and development in Arabidopsis.   DOI:  10.1111/nph.13218 ;  PMID:  25640859
• TRANSPARENT TESTA GLABRA1 and GLABRA1 Compete for Binding to GLABRA3 in Arabidopsis.   DOI:  10.1104/pp.15.00328 ;  PMID:  25926482
• Overexpressing CAPRICE and GLABRA3 did not change the anthocyanin content of tomato (Solanum lycopersicum) fruit peel.   DOI:  10.1080/15592324.2014.1000131 ;  PMID:  26039466
• WEREWOLF and ENHANCER of GLABRA3 are interdependent regulators of the spatial expression pattern of GLABRA2 in Arabidopsis.   DOI:  10.1016/j.bbrc.2015.09.115 ;  PMID:  26408906
• Arabidopsis LEAFY COTYLEDON1 controls cell fate determination during post-embryonic development.   DOI:  10.3389/fpls.2015.00955 ;  PMID:  26579186
• A single amino acid substitution in the R3 domain of GLABRA1 leads to inhibition of trichome formation in Arabidopsis without affecting its interaction with GLABRA3.   DOI:  10.1111/pce.12695 ;  PMID:  26667588
• Ectopic expression of R3 MYB transcription factor gene OsTCL1 in Arabidopsis, but not rice, affects trichome and root hair formation.   DOI:  10.1038/srep19254 ;  PMID:  26758286
• Arabidopsis thaliana G2-LIKE FLAVONOID REGULATOR and BRASSINOSTEROID ENHANCED EXPRESSION1 are low-temperature regulators of flavonoid accumulation.   DOI:  10.1111/nph.13986 ;  PMID:  27125220
• The Second Intron Is Essential for the Transcriptional Control of the Arabidopsis thaliana GLABRA3 Gene in Leaves.   DOI:  10.3389/fpls.2017.01382 ;  PMID:  28848584
• The C-terminal domains of Arabidopsis GL3/EGL3/TT8 interact with JAZ proteins and mediate dimeric interactions.   DOI:  10.1080/15592324.2017.1422460 ;  PMID:  29293407
• The novel transcription factor TRP interacts with ZFP5, a trichome initiation-related transcription factor, and negatively regulates trichome initiation through gibberellic acid signaling.   DOI:  10.1007/s11103-018-0697-x ;  PMID:  29335898
• GCN5 modulates trichome initiation in Arabidopsis by manipulating histone acetylation of core trichome initiation regulator genes.   DOI:  10.1007/s00299-019-02404-2 ;  PMID:  30927071
• Updates on molecular mechanisms in the development of branched trichome in Arabidopsis and nonbranched in cotton.   DOI:  10.1111/pbi.13167 ;  PMID:  31111642
• Arabidopsis MYB4 plays dual roles in flavonoid biosynthesis.   DOI:  10.1111/tpj.14570 ;  PMID:  31626358
• Arabidopsis ZINC FINGER PROTEIN1 Acts Downstream of GL2 to Repress Root Hair Initiation and Elongation by Directly Suppressing bHLH Genes.   DOI:  10.1105/tpc.19.00226 ;  PMID:  31732703
• Molecular Basis for a Cell Fate Switch in Response to Impaired Ribosome Biogenesis in the Arabidopsis Root Epidermis.   DOI:  10.1105/tpc.19.00773 ;  PMID:  32371546
• Arabidopsis JMJ29 is involved in trichome development by regulating the core trichome initiation gene GLABRA3.   DOI:  10.1111/tpj.14858 ;  PMID:  32445267
• Quantitative insight into the combinatorial interactions within MYB-BHLH-WD complex in Arabidopsis thaliana.   DOI:  10.17912/micropub.biology.000293 ;  PMID:  32844153
• Airborne fungus-induced biosynthesis of anthocyanins in Arabidopsis thaliana via jasmonic acid and salicylic acid signaling.   DOI:  10.1016/j.plantsci.2020.110635 ;  PMID:  33180713
• TCP transcription factors suppress cotyledon trichomes by impeding a cell differentiation-regulating complex.   DOI:  10.1093/plphys/kiab053 ;  PMID:  33576799
• The Carboxyl-Terminus of TRANSPARENT TESTA GLABRA1 Is Critical for Its Functions in Arabidopsis.   DOI:  10.3390/ijms221810039 ;  PMID:  34576199
• A molecular framework for signaling crosstalk between jasmonate and ethylene in anthocyanin biosynthesis, trichome development, and defenses against insect herbivores in Arabidopsis.   DOI:  10.1111/jipb.13319 ;  PMID:  35763421
• ARF2 positively regulates flavonols and proanthocyanidins biosynthesis in Arabidopsis thaliana.   DOI:  10.1007/s00425-022-03936-w ;  PMID:  35857143
• TOE1/TOE2 Interacting with GIS to Control Trichome Development in Arabidopsis.   DOI:  10.3390/ijms24076698 ;  PMID:  37047669
• SDG26 Is Involved in Trichome Control in Arabidopsis thaliana: Affecting Phytohormones and Adjusting Accumulation of H3K27me3 on Genes Related to Trichome Growth and Development.   DOI:  10.3390/plants12081651 ;  PMID:  37111875
• The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.   DOI:  10.1093/molbev/msg088 ;  PMID:  12679534

Sequences: