Gene Details:

• Gene ID: AT5G35750
• Gene Symbol: AHK2, HK2
• Gene Name: histidine kinase 2, histidine kinase 2
• Description: histidine kinase 2;(source:Araport11)
• TAIR Accession: locus:2177261
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G35750.1

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)

Gene Ontology:

• GO:0010271  — acts upstream of or within — regulation of chlorophyll catabolic process
• GO:0009909  — involved in — regulation of flower development
• GO:0070417  — involved in — cellular response to cold
• GO:0000155  — enables — phosphorelay sensor kinase activity
• GO:0005515  — enables — protein binding
• GO:0071215  — involved in — cellular response to abscisic acid stimulus
• GO:0000160  — involved in — phosphorelay signal transduction system
• GO:0048509  — involved in — regulation of meristem development
• GO:0010029  — acts upstream of or within — regulation of seed germination
• GO:0019900  — enables — kinase binding
• GO:0009884  — enables — cytokinin receptor activity
• GO:0009736  — acts upstream of or within — cytokinin-activated signaling pathway
• GO:0043424  — enables — protein histidine kinase binding
• GO:0004673  — enables — protein histidine kinase activity
• GO:0010087  — involved in — phloem or xylem histogenesis
• GO:0034757  — involved in — negative regulation of iron ion transport
• GO:0009414  — acts upstream of or within — response to water deprivation
• GO:0009651  — acts upstream of or within — response to salt stress
• GO:0048831  — acts upstream of or within — regulation of shoot system development
• GO:0006970  — acts upstream of or within — response to osmotic stress
• GO:0009737  — acts upstream of or within — response to abscisic acid
• GO:0009636  — involved in — response to toxic substance
• GO:0042802  — enables — identical protein binding
• GO:0005886  — located in — plasma membrane
• GO:0005034  — enables — osmosensor activity
• GO:0080117  — involved in — secondary growth

Function-related keywords:

• root

Literature:

• The Arabidopsis AHK4 histidine kinase is a cytokinin-binding receptor that transduces cytokinin signals across the membrane.   DOI:  10.1093/pcp/pce127 ;  PMID:  11577198
• The AHK4 gene involved in the cytokinin-signaling pathway as a direct receptor molecule in Arabidopsis thaliana.   DOI:  10.1093/pcp/pce094 ;  PMID:  11479382
• The Arabidopsis sensor His-kinase, AHk4, can respond to cytokinins.   DOI:  10.1093/pcp/pce037 ;  PMID:  11230563
• Novel family of sensor histidine kinase genes in Arabidopsis thaliana.   DOI:  10.1093/pcp/pce015 ;  PMID:  11230578
• Two-component signal transduction pathways in Arabidopsis.   DOI:  10.1104/pp.005504 ;  PMID:  12068096
• His-Asp phosphorelay signal transduction in higher plants: receptors and response regulators for cytokinin signaling in Arabidopsis thaliana.   DOI:  10.1266/ggs.77.383 ;  PMID:  12589073
• Cytokinin signal transduction in plant cells.   DOI:  10.1007/s10265-003-0094-6 ;  PMID:  12836044
• Histidine kinase homologs that act as cytokinin receptors possess overlapping functions in the regulation of shoot and root growth in Arabidopsis.   DOI:  10.1105/tpc.021477 ;  PMID:  15155880
• In planta functions of the Arabidopsis cytokinin receptor family.   DOI:  10.1073/pnas.0402887101 ;  PMID:  15166290
• Interaction between phosphate-starvation, sugar, and cytokinin signaling in Arabidopsis and the roles of cytokinin receptors CRE1/AHK4 and AHK3.   DOI:  10.1104/pp.105.060517 ;  PMID:  15923327
• Arabidopsis cytokinin receptor mutants reveal functions in shoot growth, leaf senescence, seed size, germination, root development, and cytokinin metabolism.   DOI:  10.1105/tpc.105.037796 ;  PMID:  16361392
• Cytokinin receptors are required for normal development of auxin-transporting vascular tissues in the hypocotyl but not in adventitious roots.   DOI:  10.1093/pcp/pci240 ;  PMID:  16357038
• Cytokinins regulate a bidirectional phosphorelay network in Arabidopsis.   DOI:  10.1016/j.cub.2006.04.030 ;  PMID:  16753566
• Cytokinin receptors are involved in alkamide regulation of root and shoot development in Arabidopsis.   DOI:  10.1104/pp.107.107953 ;  PMID:  17965178
• Identification of amino acid substitutions that render the Arabidopsis cytokinin receptor histidine kinase AHK4 constitutively active.   DOI:  10.1093/pcp/pcm145 ;  PMID:  17956858
• Three type-B response regulators, ARR1, ARR10 and ARR12, play essential but redundant roles in cytokinin signal transduction throughout the life cycle of Arabidopsis thaliana.   DOI:  10.1093/pcp/pcm165 ;  PMID:  18037673
• Functional analysis of AHK1/ATHK1 and cytokinin receptor histidine kinases in response to abscisic acid, drought, and salt stress in Arabidopsis.   DOI:  10.1073/pnas.0706547105 ;  PMID:  18077346
• Zeatin-induced nitric oxide (NO) biosynthesis in Arabidopsis thaliana mutants of NO biosynthesis and of two-component signaling genes.   DOI:  10.1111/j.1469-8137.2008.02383.x ;  PMID:  18298431
• Toward an interaction map of the two-component signaling pathway of Arabidopsis thaliana.   DOI:  10.1021/pr0703831 ;  PMID:  18642946
• Type B response regulators of Arabidopsis play key roles in cytokinin signaling and plant development.   DOI:  10.1105/tpc.108.059584 ;  PMID:  18723577
• The role of auxins and cytokinins in the mutualistic interaction between Arabidopsis and Piriformospora indica.   DOI:  10.1094/MPMI-21-10-1371 ;  PMID:  18785832
• Reproductive organs regulate leaf nitrogen metabolism mediated by cytokinin signal.   DOI:  10.1007/s00425-008-0858-2 ;  PMID:  19048287
• The histidine kinases CYTOKININ-INDEPENDENT1 and ARABIDOPSIS HISTIDINE KINASE2 and 3 regulate vascular tissue development in Arabidopsis shoots.   DOI:  10.1105/tpc.109.066696 ;  PMID:  19622803
• Cytokinin overproduction-caused alteration of flower development is partially mediated by CUC2 and CUC3 in Arabidopsis.   DOI:  10.1016/j.gene.2009.11.003 ;  PMID:  19913077
• STIMPY mediates cytokinin signaling during shoot meristem establishment in Arabidopsis seedlings.   DOI:  10.1242/dev.041426 ;  PMID:  20110319
• A subset of cytokinin two-component signaling system plays a role in cold temperature stress response in Arabidopsis.   DOI:  10.1074/jbc.M109.096644 ;  PMID:  20463025
• E. coli-based cell-free expression, purification and characterization of the membrane-bound ligand-binding CHASE-TM domain of the cytokinin receptor CRE1/AHK4 of Arabidopsis thaliana.   DOI:  10.1007/s12033-010-9331-0 ;  PMID:  20886313
• The specificity of cytokinin signalling in Arabidopsis thaliana is mediated by differing ligand affinities and expression profiles of the receptors.   DOI:  10.1111/j.1365-313X.2011.04584.x ;  PMID:  21426428
• Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system.   DOI:  10.1016/j.phytochem.2011.02.029 ;  PMID:  21477822
• The cytokinin receptors of Arabidopsis are located mainly to the endoplasmic reticulum.   DOI:  10.1104/pp.111.180539 ;  PMID:  21709172
• Bacterial assay to study plant sensor histidine kinases.   DOI:  10.1007/978-1-61779-264-9_7 ;  PMID:  21837564
• N-glucosyltransferase UGT76C2 is involved in cytokinin homeostasis and cytokinin response in Arabidopsis thaliana.   DOI:  10.1093/pcp/pcr152 ;  PMID:  22051886
• Programmed cell death induced by high levels of cytokinin in Arabidopsis cultured cells is mediated by the cytokinin receptor CRE1/AHK4.   DOI:  10.1093/jxb/ers008 ;  PMID:  22312114
• Cytokinin receptor-dependent and receptor-independent pathways in the dehydration response of Arabidopsis thaliana.   DOI:  10.1016/j.jplph.2012.05.007 ;  PMID:  22704545
• Arabidopsis response Regulator1 and Arabidopsis histidine phosphotransfer Protein2 (AHP2), AHP3, and AHP5 function in cold signaling.   DOI:  10.1104/pp.112.207621 ;  PMID:  23124324
• A novel protective function for cytokinin in the light stress response is mediated by the Arabidopsis histidine kinase2 and Arabidopsis histidine kinase3 receptors.   DOI:  10.1104/pp.113.224667 ;  PMID:  24424319
• Lateral root formation and growth of Arabidopsis is redundantly regulated by cytokinin metabolism and signalling genes.   DOI:  10.1093/jxb/ert291 ;  PMID:  24023250
• Involvement of two-component signalling systems in the regulation of stomatal aperture by light in Arabidopsis thaliana.   DOI:  10.1111/nph.12813 ;  PMID:  24758561
• Stress physiology functions of the Arabidopsis histidine kinase cytokinin receptors.   DOI:  10.1111/ppl.12290 ;  PMID:  25263537
• and AHK3-like cytokinin receptors in Brassica napus reveals two subfamilies of AHK2 orthologues.   DOI:  10.1093/jxb/eru422 ;  PMID:  25336686
• Plant membrane assays with cytokinin receptors underpin the unique role of free cytokinin bases as biologically active ligands.   DOI:  10.1093/jxb/eru522 ;  PMID:  25609827
• The Sensor Histidine Kinases AHK2 and AHK3 Proceed into Multiple Serine/Threonine/Tyrosine Phosphorylation Pathways in Arabidopsis thaliana.   DOI:  10.1016/j.molp.2015.10.002 ;  PMID:  26485051
• Volatile compounds emitted by diverse phytopathogenic microorganisms promote plant growth and flowering through cytokinin action.   DOI:  10.1111/pce.12759 ;  PMID:  27092473
• Cytokinin Regulates the Etioplast-Chloroplast Transition through the Two-Component Signaling System and Activation of Chloroplast-Related Genes.   DOI:  10.1104/pp.16.00640 ;  PMID:  27388681
• Plastid osmotic stress influences cell differentiation at the plant shoot apex.   DOI:  10.1242/dev.136234 ;  PMID:  27510974
• Gain-of-Function Mutants of the Cytokinin Receptors AHK2 and AHK3 Regulate Plant Organ Size, Flowering Time and Plant Longevity.   DOI:  10.1104/pp.16.01903 ;  PMID:  28096190
• Opposite roles of the Arabidopsis cytokinin receptors AHK2 and AHK3 in the expression of plastid genes and genes for the plastid transcriptional machinery during senescence.   DOI:  10.1007/s11103-016-0580-6 ;  PMID:  28150126
• Divergent expression of cytokinin biosynthesis, signaling and catabolism genes underlying differences in feeding sites induced by cyst and root-knot nematodes.   DOI:  10.1111/tpj.13647 ;  PMID:  28746737
• Cytokinin activity of N(6)-benzyladenine derivatives assayed by interaction with the receptors in planta, in vitro, and in silico.   DOI:  10.1016/j.phytochem.2018.02.008 ;  PMID:  29544164
• Crosstalk between the cytokinin and MAX2 signaling pathways in growth and callus formation of Arabidopsis thaliana.   DOI:  10.1016/j.bbrc.2019.02.038 ;  PMID:  30795866
• The role of cytokinin in selenium stress response in Arabidopsis.   DOI:  10.1016/j.plantsci.2019.01.028 ;  PMID:  30824045
• Nitrate Induction of Primary Root Growth Requires Cytokinin Signaling in Arabidopsis thaliana.   DOI:  10.1093/pcp/pcz199 ;  PMID:  31730198
• Studies of cytokinin receptor-phosphotransmitter interaction provide evidences for the initiation of cytokinin signalling in the endoplasmic reticulum.   DOI:  10.1071/FP16292 ;  PMID:  32291033
• Photoperiod stress induces an oxidative burst-like response and is associated with increased apoplastic peroxidase and decreased catalase activities.   DOI:  10.1016/j.jplph.2020.153252 ;  PMID:  32949889
• Azospirillum brasilense Sp245 triggers cytokinin signaling in root tips and improves biomass accumulation in Arabidopsis through canonical cytokinin receptors.   DOI:  10.1007/s12298-021-01036-9 ;  PMID:  34539107
• Root-specific Reduction of Cytokinin Perception Enhances Shoot Growth in Arabidopsis thaliana.   DOI:  10.1093/pcp/pcac013 ;  PMID:  35134216
• Back From the Dead: The Atypical Kinase Activity of a Pseudokinase Regulator of Cation Fluxes During Inducible Immunity.   DOI:  10.3389/fpls.2022.931324 ;  PMID:  36035673
• In Planta, In Vitro and In Silico Studies of Chiral N(6)-Benzyladenine Derivatives: Discovery of Receptor-Specific S-Enantiomers with Cytokinin or Anticytokinin Activities.   DOI:  10.3390/ijms231911334 ;  PMID:  36232653
• The Role of a Cytokinin Antagonist in the Progression of Clubroot Disease.   DOI:  10.3390/biom13020299 ;  PMID:  36830668
• Reproductive organs regulate leaf nitrogen metabolism mediated by cytokinin signal.   DOI:  10.1007/s00425-008-0858-2 ;  PMID:  19048287

Sequences: