Gene Details:

• Gene ID: AT5G35410
• Gene Symbol: ATSOS2, CIPK24, SNRK3.11, SOS2
• Gene Name: SALT OVERLY SENSITIVE 2, CBL-INTERACTING PROTEIN KINASE 24, SNF1-RELATED PROTEIN KINASE 3.11, SALT OVERLY SENSITIVE 2
• Description: Protein kinase superfamily protein;(source:Araport11)
• TAIR Accession: locus:2155233
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G35410.1     AT5G35410.2

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0000084  — plant sperm cell — célula espermática o esperma (Spanish, exact), male gamete (exact), microgamete (exact), 植物精子細胞 (Japanese, exact), sperm nucleus (related), sperm cell (broad)

Gene Ontology:

• GO:0005515  — enables — protein binding
• GO:0004674  — enables — protein serine/threonine kinase activity
• GO:0009705  — located in — plant-type vacuole membrane
• GO:0006468  — involved in — protein phosphorylation
• GO:0009651  — acts upstream of or within — response to salt stress
• GO:0005737  — located in — cytoplasm
• GO:0004672  — enables — protein kinase activity
• GO:0035556  — involved in — intracellular signal transduction
• GO:0007165  — involved in — signal transduction

Function-related keywords:

• root ,  root ,  plant sperm cell

Literature:

• The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na+/H+ antiporter.   DOI:  10.1073/pnas.120170197 ;  PMID:  10823923
• The Arabidopsis SOS2 protein kinase physically interacts with and is activated by the calcium-binding protein SOS3.   DOI:  10.1073/pnas.97.7.3735 ;  PMID:  10725350
• Genetic analysis of salt tolerance in arabidopsis. Evidence for a critical role of potassium nutrition.   DOI:  10.1105/tpc.10.7.1181 ;  PMID:  9668136
• Interaction specificity of Arabidopsis calcineurin B-like calcium sensors and their target kinases.   DOI:  10.1104/pp.124.4.1844 ;  PMID:  11115898
• Genes that are uniquely stress regulated in salt overly sensitive (sos) mutants.   DOI:  10.1104/pp.126.1.363 ;  PMID:  11351099
• Ion homeostasis during salt stress in plants.   DOI:  10.1016/s0955-0674(00)00227-1 ;  PMID:  11454443
• Reconstitution in yeast of the Arabidopsis SOS signaling pathway for Na+ homeostasis.   DOI:  10.1073/pnas.132092099 ;  PMID:  12070350
• Differential expression and function of Arabidopsis thaliana NHX Na+/H+ antiporters in the salt stress response.   DOI:  10.1046/j.1365-313x.2002.01309.x ;  PMID:  12047628
• Regulation of SOS1, a plasma membrane Na+/H+ exchanger in Arabidopsis thaliana, by SOS2 and SOS3.   DOI:  10.1073/pnas.122224699 ;  PMID:  12034882
• Regulation of expression of the vacuolar Na+/H+ antiporter gene AtNHX1 by salt stress and abscisic acid.   DOI:  10.1023/a:1019859319617 ;  PMID:  12369629
• The Arabidopsis CDPK-SnRK superfamily of protein kinases.   DOI:  10.1104/pp.102.011999 ;  PMID:  12805596
• Regulation of vacuolar Na+/H+ exchange in Arabidopsis thaliana by the salt-overly-sensitive (SOS) pathway.   DOI:  10.1074/jbc.M307982200 ;  PMID:  14570921
• The protein kinase SOS2 activates the Arabidopsis H(+)/Ca(2+) antiporter CAX1 to integrate calcium transport and salt tolerance.   DOI:  10.1074/jbc.M309084200 ;  PMID:  14583601
• Transgenic evaluation of activated mutant alleles of SOS2 reveals a critical requirement for its kinase activity and C-terminal regulatory domain for salt tolerance in Arabidopsis thaliana.   DOI:  10.1105/tpc.019174 ;  PMID:  14742879
• Salinity-induced ion flux patterns from the excised roots of Arabidopsis sos mutants.   DOI:  10.1007/s00425-005-0074-2 ;  PMID:  16079998
• Salt stress affects cortical microtubule organization and helical growth in Arabidopsis.   DOI:  10.1093/pcp/pcj090 ;  PMID:  16861712
• Conservation of the salt overly sensitive pathway in rice.   DOI:  10.1104/pp.106.092635 ;  PMID:  17142477
• SCABP8/CBL10, a putative calcium sensor, interacts with the protein kinase SOS2 to protect Arabidopsis shoots from salt stress.   DOI:  10.1105/tpc.106.042291 ;  PMID:  17449811
• Interaction of SOS2 with nucleoside diphosphate kinase 2 and catalases reveals a point of connection between salt stress and H2O2 signaling in Arabidopsis thaliana.   DOI:  10.1128/MCB.00429-07 ;  PMID:  17785451
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.   DOI:  10.1104/pp.108.126375 ;  PMID:  18775970
• The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3.   DOI:  10.1016/j.molcel.2007.04.013 ;  PMID:  17499048
• SOS2 promotes salt tolerance in part by interacting with the vacuolar H+-ATPase and upregulating its transport activity.   DOI:  10.1128/MCB.00430-07 ;  PMID:  17875927
• and salt-stress signaling in plants: shedding light on SOS pathway.   DOI:  10.1016/j.abb.2008.01.010 ;  PMID:  18241665
• Overexpression of SOS (Salt Overly Sensitive) genes increases salt tolerance in transgenic Arabidopsis.   DOI:  10.1093/mp/ssn058 ;  PMID:  19529826
• Na(+)/H(+) antiporter activity of the SOS1 gene: lifetime imaging analysis and electrophysiological studies on Arabidopsis seedlings.   DOI:  10.1111/j.1399-3054.2009.01274.x ;  PMID:  19758408
• Regulation by salt of vacuolar H+-ATPase and H+-pyrophosphatase activities and Na+/H+ exchange.   DOI:  10.4161/psb.4.8.9236 ;  PMID:  19820346
• Functional analysis of TaDi19A, a salt-responsive gene in wheat.   DOI:  10.1111/j.1365-3040.2009.02063.x ;  PMID:  19895399
• The woody plant poplar has a functionally conserved salt overly sensitive pathway in response to salinity stress.   DOI:  10.1007/s11103-010-9680-x ;  PMID:  20803312
• Comparative genomic analysis of 1047 completely sequenced cDNAs from an Arabidopsis-related model halophyte, Thellungiella halophila.   DOI:  10.1186/1471-2229-10-261 ;  PMID:  21106055
• and K(+)-sensitive 1, regulates ion homeostasis in an SOS-independent pathway in Arabidopsis.   DOI:  10.1016/j.phytochem.2010.12.005 ;  PMID:  21227472
• Species specific amino acid sequence-protein local structure relationships: An analysis in the light of a structural alphabet.   DOI:  10.1016/j.jtbi.2011.01.047 ;  PMID:  21333657
• Activation of the plasma membrane Na/H antiporter Salt-Overly-Sensitive 1 (SOS1) by phosphorylation of an auto-inhibitory C-terminal domain.   DOI:  10.1073/pnas.1018921108 ;  PMID:  21262798
• Autophosphorylation profiling of Arabidopsis protein kinases using the cell-free system.   DOI:  10.1016/j.phytochem.2011.02.029 ;  PMID:  21477822
• Phosphorylation of SOS3-like calcium-binding proteins by their interacting SOS2-like protein kinases is a common regulatory mechanism in Arabidopsis.   DOI:  10.1104/pp.111.173377 ;  PMID:  21685179
• Molecular cloning and functional characterization of a novel apple MdCIPK6L gene reveals its involvement in multiple abiotic stress tolerance in transgenic plants.   DOI:  10.1007/s11103-012-9899-9 ;  PMID:  22382993
• Phosphorylation of calcineurin B-like (CBL) calcium sensor proteins by their CBL-interacting protein kinases (CIPKs) is required for full activity of CBL-CIPK complexes toward their target proteins.   DOI:  10.1074/jbc.M111.279331 ;  PMID:  22253446
• A novel protein kinase involved in Na(+) exclusion revealed from positional cloning.   DOI:  10.1111/j.1365-3040.2012.02595.x ;  PMID:  22897323
• Expression, purification and analysis of an Arabidopsis recombinant CBL-interacting protein kinase3 (CIPK3) and its constitutively active form.   DOI:  10.1016/j.pep.2012.08.013 ;  PMID:  22985939
• Release of SOS2 kinase from sequestration with GIGANTEA determines salt tolerance in Arabidopsis.   DOI:  10.1038/ncomms2357 ;  PMID:  23322040
• Structural insights on the plant salt-overly-sensitive 1 (SOS1) Na(+)/H(+) antiporter.   DOI:  10.1016/j.jmb.2012.09.015 ;  PMID:  23022605
• A role for GIGANTEA: keeping the balance between flowering and salinity stress tolerance.   DOI:  10.4161/psb.24820 ;  PMID:  23656866
• Co-expression of the Arabidopsis SOS genes enhances salt tolerance in transgenic tall fescue (Festuca arundinacea Schreb.).   DOI:  10.1007/s00709-013-0540-9 ;  PMID:  24022678
• Heterologous expression of the wheat aquaporin gene TaTIP2;2 compromises the abiotic stress tolerance of Arabidopsis thaliana.   DOI:  10.1371/journal.pone.0079618 ;  PMID:  24223981
• Identification of TaWD40D, a wheat WD40 repeat-containing protein that is associated with plant tolerance to abiotic stresses.   DOI:  10.1007/s00299-014-1717-1 ;  PMID:  25447637
• Chrysanthemum WRKY gene CmWRKY17 negatively regulates salt stress tolerance in transgenic chrysanthemum and Arabidopsis plants.   DOI:  10.1007/s00299-015-1793-x ;  PMID:  25893877
• CYCLIN-DEPENDENT KINASE G2 regulates salinity stress response and salt mediated flowering in Arabidopsis thaliana.   DOI:  10.1007/s11103-015-0324-z ;  PMID:  25948280
• Arabidopsis CALCINEURIN B-LIKE10 Functions Independently of the SOS Pathway during Reproductive Development in Saline Conditions.   DOI:  10.1104/pp.16.00334 ;  PMID:  26979332
• Structural basis of the regulatory mechanism of the plant CIPK family of protein kinases controlling ion homeostasis and abiotic stress.   DOI:  10.1073/pnas.1407610111 ;  PMID:  25288725
• EIN3 and SOS2 synergistically modulate plant salt tolerance.   DOI:  10.1038/srep44637 ;  PMID:  28300216
• The AtrbohF-dependent regulation of ROS signaling is required for melatonin-induced salinity tolerance in Arabidopsis.   DOI:  10.1016/j.freeradbiomed.2017.04.009 ;  PMID:  28412199
• A novel cotton WRKY gene, GhWRKY6-like, improves salt tolerance by activating the ABA signaling pathway and scavenging of reactive oxygen species.   DOI:  10.1111/ppl.12651 ;  PMID:  29027659
• Glutamate Receptor Homolog3.4 is Involved in Regulation of Seed Germination Under Salt Stress in Arabidopsis.   DOI:  10.1093/pcp/pcy034 ;  PMID:  29432559
• AtDIV2, an R-R-type MYB transcription factor of Arabidopsis, negatively regulates salt stress by modulating ABA signaling.   DOI:  10.1007/s00299-018-2321-6 ;  PMID:  30014159
• Pseudomonas knackmussii MLR6, a rhizospheric strain isolated from halophyte, enhances salt tolerance in Arabidopsis thaliana.   DOI:  10.1111/jam.14082 ;  PMID:  30142236
• SENSITIVE TO SALT1, An Endoplasmic Reticulum-Localized Chaperone, Positively Regulates Salt Resistance.   DOI:  10.1104/pp.18.00840 ;  PMID:  30287478
• Calcium-activated 14-3-3 proteins as a molecular switch in salt stress tolerance.   DOI:  10.1038/s41467-019-09181-2 ;  PMID:  30867421
• The SOS2-SCaBP8 Complex Generates and Fine-Tunes an AtANN4-Dependent Calcium Signature under Salt Stress.   DOI:  10.1016/j.devcel.2019.02.010 ;  PMID:  30861376
• Calcineurin B-Like Proteins CBL4 and CBL10 Mediate Two Independent Salt Tolerance Pathways in Arabidopsis.   DOI:  10.3390/ijms20102421 ;  PMID:  31100786
• The protein kinase complex CBL10-CIPK8-SOS1 functions in Arabidopsis to regulate salt tolerance.   DOI:  10.1093/jxb/erz549 ;  PMID:  31858132
• The plasma-membrane polyamine transporter PUT3 is regulated by the Na(+) /H(+) antiporter SOS1 and protein kinase SOS2.   DOI:  10.1111/nph.16407 ;  PMID:  31901205
• Salinity Stress-Mediated Suppression of Expression of Salt Overly Sensitive Signaling Pathway Genes Suggests Negative Regulation by AtbZIP62 Transcription Factor in Arabidopsis thaliana.   DOI:  10.3390/ijms21051726 ;  PMID:  32138325
• E2 conjugases UBC1 and UBC2 regulate MYB42-mediated SOS pathway in response to salt stress in Arabidopsis.   DOI:  10.1111/nph.16538 ;  PMID:  32167578
• 14-3-3 Proteins and Other Candidates form Protein-Protein Interactions with the Cytosolic C-terminal End of SOS1 Affecting Its Transport Activity.   DOI:  10.3390/ijms21093334 ;  PMID:  32397251
• ESCRT-I Component VPS23A Sustains Salt Tolerance by Strengthening the SOS Module in Arabidopsis.   DOI:  10.1016/j.molp.2020.05.010 ;  PMID:  32439321
• PLATZ2 negatively regulates salt tolerance in Arabidopsis seedlings by directly suppressing the expression of the CBL4/SOS3 and CBL10/SCaBP8 genes.   DOI:  10.1093/jxb/eraa259 ;  PMID:  32453821
• The GSK3-like Kinase BIN2 Is a Molecular Switch between the Salt Stress Response and Growth Recovery in Arabidopsis thaliana.   DOI:  10.1016/j.devcel.2020.08.005 ;  PMID:  32891194
• A Salt-Signaling Network Involving Ethylene, Extracellular ATP, Hydrogen Peroxide, and Calcium Mediates K(+)/Na(+) Homeostasis in Arabidopsis.   DOI:  10.3390/ijms21228683 ;  PMID:  33213111
• Identification and Functional Analysis of Two Purple Acid Phosphatases AtPAP17 and AtPAP26 Involved in Salt Tolerance in Arabidopsis thaliana Plant.   DOI:  10.3389/fpls.2020.618716 ;  PMID:  33679819
• Ethylene signaling in salt-stressed Arabidopsis thaliana ein2-1 and ctr1-1 A dissection of molecular mechanisms involved in acclimation.   DOI:  10.1016/j.plaphy.2021.09.029 ;  PMID:  34592706
• Distinct Roles of N-Terminal Fatty Acid Acylation of the Salinity-Sensor Protein SOS3.   DOI:  10.3389/fpls.2021.691124 ;  PMID:  34630451
• Interactome of Arabidopsis Thaliana.   DOI:  10.3390/plants11030350 ;  PMID:  35161331
• Linker histone variant HIS1-3 and WRKY1 oppositely regulate salt stress tolerance in Arabidopsis.   DOI:  10.1093/plphys/kiac174 ;  PMID:  35474141
• Arabidopsis Toxicos en Levadura 12 Modulates Salt Stress and ABA Responses in Arabidopsis thaliana.   DOI:  10.3390/ijms23137290 ;  PMID:  35806295
• Karrikin Receptor KAI2 Coordinates Salt Tolerance Mechanisms in Arabidopsis thaliana.   DOI:  10.1093/pcp/pcac121 ;  PMID:  35997763
• SALT OVERLY SENSITIVE 1 is inhibited by clade D Protein phosphatase 2C D6 and D7 in Arabidopsis thaliana.   DOI:  10.1093/plcell/koac283 ;  PMID:  36149299
• S-acylated and nucleus-localized SALT OVERLY SENSITIVE3/CALCINEURIN B-LIKE4 stabilizes GIGANTEA to regulate Arabidopsis flowering time under salt stress.   DOI:  10.1093/plcell/koac289 ;  PMID:  36135824
• RAP2.6 enhanced salt stress tolerance by reducing Na(+) accumulation and stabilizing the electron transport in Arabidopsis thaliana.   DOI:  10.1016/j.plaphy.2023.01.003 ;  PMID:  36634508
• Phosphatidic acid-regulated SOS2 controls sodium and potassium homeostasis in Arabidopsis under salt stress.   DOI:  10.15252/embj.2022112401 ;  PMID:  36811145
• SALT OVERLY SENSITIVE2 stabilizes phytochrome-interacting factors PIF4 and PIF5 to promote Arabidopsis shade avoidance.   DOI:  10.1093/plcell/koad119 ;  PMID:  37119311
• Phytochromes enhance SOS2-mediated PIF1 and PIF3 phosphorylation and degradation to promote Arabidopsis salt tolerance.   DOI:  10.1093/plcell/koad117 ;  PMID:  37119239
• A salt stress-activated GSO1-SOS2-SOS1 module protects the Arabidopsis root stem cell niche by enhancing sodium ion extrusion.   DOI:  10.15252/embj.2022113004 ;  PMID:  37211994

Sequences: