Gene Details:
- Gene ID: AT5G27807
- Gene Symbol: EEP1, MIR164, MIR164C
- Gene Name: EARLY EXTRA PETALS 1, MICRORNA 164, microRNA164C
- Description: microRNA ath-MIR164c precursor;(source:Araport11)
- TAIR Accession: locus:1009023466
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0000017 — vascular leaf primordium — leaf primordium (exact), portion of vascular leaf primordium tissue (exact), primordio de hoja (Spanish, exact), vascular leaf primordia (exact, plural), 葉原基 (Japanese, exact)
- PO:0020148 — shoot apical meristem — SAM (exact), meristema apical del epiblasto (epiblastema) (Spanish, exact), 茎頂分裂組織 (Japanese, exact), primary shoot meristem (related), promeristem (broad)
- PO:0000229 — flower meristem — floral meristem (exact), mersitema floral (Spanish, exact), 花芽分裂組織 (Japanese, exact), floral apical meristem (related), Poaceae floret meristem (narrow), ear floret meristem (narrow), floret meristem (narrow), tassel floret meristem (narrow)
- PO:0000230 — inflorescence meristem — meristema de la inflorescencia (Spanish, exact), 花序分裂組織 (Japanese, exact)
- PO:0005021 — sepal margin — margen del sépalo (Spanish, exact), がく片縁 (Japanese, exact)
- PO:0009030 — carpel — carpelo (Spanish, exact), 心皮 (Japanese, exact), Poaceae carpel (narrow), Zea carpel (narrow), pistil (broad)
Gene Ontology:
- GO:0035195 — acts upstream of or within — miRNA-mediated gene silencing
- GO:0045892 — acts upstream of or within — negative regulation of DNA-templated transcription
- GO:0005575 — is active in — cellular_component
- GO:0010150 — acts upstream of or within — leaf senescence
- GO:0048835 — acts upstream of or within — specification of decreased petal number
- GO:0048451 — acts upstream of or within — petal formation
- GO:0000900 — enables — mRNA regulatory element binding translation repressor activity
Germplasm Phenotype:
- CS65826 — Extra petals in early-arising flowers due to a loss of function of miR164c, which leads to increased levels of CUC1 and CUC2.
- CS65828 — Slightly increased leaf serration during vegetative development; increased number of sepals and petals during reproductive development; irregular flower arrangement due to repressed cell division in the internodes that separate individual flowers.
- CS65837 — No visible phenotype.
- eep1 — Flowers have more petals than the wild-type, particularly in the first 10 flowers. Four petal primordia are initiated in the same positions as in wild-type. The extra petals, if initiated, always arise adjacent to these normally positioned petals. Occasionally, petals form incisions at their distal tip and adopt a heart shape. There is also a subtle carpel fusion defect at the distal end of the gynoecium in a small portion of mutant flowers. The organ-number defect is petal specific. In mutant plants, the transcript levels of the transcription factors CUC1 and CUC2 are significantly increased compared to wild-type. Overall expression domains of CUC1 and CUC2 appear to be normal. However, during floral stages 5-7, extra CUC1- and CUC2-expressing cells are observed in the second whorl.
- mir164abc — Plants appear normal during vegetative growth. Phenotypic alterations start after the switch to reproductive development. Flowers have an increased number of sepals and petals. Floral organ numbers are highly variable. Individual organs varied in size. Carpels failed to fuse resulting in severe reduction of fertility. In addition, plants display a highly unequal and distorted arrangement of flowers, both with respect to the angle formed by two consecutive flowers and their distance from each other along the axis of the stem.
Function-related keywords:
- vascular leaf primordium , shoot apical meristem , flower meristem , inflorescence meristem , sepal margin , carpel
Literature:
- microRNA-directed phasing during trans-acting siRNA biogenesis in plants. DOI: 10.1016/j.cell.2005.04.004 ; PMID: 15851028
- MicroRNA directs mRNA cleavage of the transcription factor NAC1 to downregulate auxin signals for arabidopsis lateral root development. DOI: 10.1105/tpc.105.030841 ; PMID: 15829603
- Arabidopsis small RNAs and their targets during cyst nematode parasitism. DOI: 10.1094/MPMI-21-12-1622 ; PMID: 18986258
- Gene structures and processing of Arabidopsis thaliana HYL1-dependent pri-miRNAs. DOI: 10.1093/nar/gkp189 ; PMID: 19304749
- An array platform for identification of stress-responsive microRNAs in plants. DOI: 10.1007/978-1-60761-702-0_15 ; PMID: 20387051
- Sculpting the flower; the role of microRNAs in flower development. DOI: 10.1016/S0070-2153(10)91012-0 ; PMID: 20705188
- TCP transcription factors regulate the activities of ASYMMETRIC LEAVES1 and miR164, as well as the auxin response, during differentiation of leaves in Arabidopsis. DOI: 10.1105/tpc.110.075598 ; PMID: 21119060
- Evolution and diverse roles of the CUP-SHAPED COTYLEDON genes in Arabidopsis leaf development. DOI: 10.1105/tpc.110.081448 ; PMID: 21258003
- Transcriptional and post-transcriptional regulation of a NAC1 transcription factor in Medicago truncatula roots. DOI: 10.1111/j.1469-8137.2011.03719.x ; PMID: 21770944
- miRNA164-directed cleavage of ZmNAC1 confers lateral root development in maize (Zea mays L.). DOI: 10.1186/1471-2229-12-220 ; PMID: 23171309
- Identification of miRNAs associated with dark-induced senescence in Arabidopsis. DOI: 10.1186/s12870-015-0656-5 ; PMID: 26530097
- A Conserved Role for the NAM/miR164 Developmental Module Reveals a Common Mechanism Underlying Carpel Margin Fusion in Monocarpous and Syncarpous Eurosids. DOI: 10.3389/fpls.2015.01239 ; PMID: 26793217
- Combinations of Mutations Sufficient to Alter Arabidopsis Leaf Dissection. DOI: 10.3390/plants2020230 ; PMID: 27137374
- Regulation of MicroRNA-Mediated Developmental Changes by the SWR1 Chromatin Remodeling Complex. DOI: 10.1104/pp.16.00332 ; PMID: 27208270
- An Arabidopsis NAC transcription factor NAC4 promotes pathogen-induced cell death under negative regulation by microRNA164. DOI: 10.1111/nph.14371 ; PMID: 28032643
- MicroRNAs Are Intensively Regulated during Induction of Somatic Embryogenesis in Arabidopsis. DOI: 10.3389/fpls.2017.00018 ; PMID: 28167951
- Arabidopsis thaliana miRNAs promote embryo pattern formation beginning in the zygote. DOI: 10.1016/j.ydbio.2017.09.009 ; PMID: 28912016
- Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network. DOI: 10.1242/dev.157081 ; PMID: 29650590
- Circadian control of ORE1 by PRR9 positively regulates leaf senescence in Arabidopsis. DOI: 10.1073/pnas.1722407115 ; PMID: 30065116
- Genome-wide profiling of sRNAs in the Verticillium dahliae-infected Arabidopsis roots. DOI: 10.1080/21501203.2018.1426062 ; PMID: 30181922
- Genome-wide identification and comprehensive analysis of the NAC transcription factor family in sunflower during salt and drought stress. DOI: 10.1038/s41598-021-98107-4 ; PMID: 34615898
- MIR164b represses iron uptake by regulating the NAC domain transcription factor5-Nuclear Factor Y, Subunit A8 module in Arabidopsis. DOI: 10.1093/plphys/kiac114 ; PMID: 35285505
- Scaffold protein RACK1A positively regulates leaf senescence by coordinating the EIN3-miR164-ORE1 transcriptional cascade in Arabidopsis. DOI: 10.1111/jipb.13483 ; PMID: 36939002
- MicroRNA regulation of NAC-domain targets is required for proper formation and separation of adjacent embryonic, vegetative, and floral organs. DOI: 10.1016/j.cub.2004.06.022 ; PMID: 15202996
- Computational identification of plant microRNAs and their targets, including a stress-induced miRNA. DOI: 10.1016/j.molcel.2004.05.027 ; PMID: 15200956
- MicroRNA regulation of the CUC genes is required for boundary size control in Arabidopsis meristems. DOI: 10.1242/dev.01320 ; PMID: 15294871
- microRNA-directed phasing during trans-acting siRNA biogenesis in plants. DOI: 10.1016/j.cell.2005.04.004 ; PMID: 15851028
- Spatio-temporal accumulation of microRNAs is highly coordinated in developing plant tissues. DOI: 10.1111/j.1365-313X.2006.02766.x ; PMID: 16824182
- The balance between the MIR164A and CUC2 genes controls leaf margin serration in Arabidopsis. DOI: 10.1105/tpc.106.045617 ; PMID: 17098808
- TCP transcription factors control the morphology of shoot lateral organs via negative regulation of the expression of boundary-specific genes in Arabidopsis. DOI: 10.1105/tpc.106.044792 ; PMID: 17307931
- Interplay of miR164, CUP-SHAPED COTYLEDON genes and LATERAL SUPPRESSOR controls axillary meristem formation in Arabidopsis thaliana. DOI: 10.1111/j.1365-313X.2008.03483.x ; PMID: 18346190
Sequences:
cDNA Sequence
CDS Sequence
Protein Sequence