Gene Details:
- Gene ID: AT5G27380
- Gene Symbol: AtGSH2, GSH2, GSHB
- Gene Name: glutathione synthetase 2
- Description: glutathione synthetase 2;(source:Araport11)
- TAIR Accession:
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Plant Ontology Annotations:
- PO:0006504 — leaf trichome — tricoma de hoja (Spanish, exact), 葉毛(毛茸、糸状体) (Japanese, exact), phyllid trichome (narrow)
- PO:0009005 — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
- PO:0000293 — guard cell — célula guardiana (Spanish, exact), occlusive cell (exact), 孔辺細胞 (Japanese, exact)
Germplasm Phenotype:
- CS68140 — Bleached embryo and seedling lethal phenotype. GSH-supplemented growth allows partial rescue of homozygous mutants leading to partial greening, stunted growth, and delayed lethality.
- CS69965 — Moderately reduced luciferase response to cadmium compared to pSULTR1;2::LUC parental control reporter line (CS69963). Yellow leaves and reduced seedling size. Elevated levels of cysteine and gamma-glutamylcysteine (gamma-EC), decreased level of glutathione (GSH), and shorter roots in the presence of cadmium compared to parental control.
- SAIL_301_C06 — Seedling lethal. 25% seeds of the selfed heterozygous plant gave rise to small, white seedlings that ceased growth soon after germination. Bleached mutant embryos contained no detectable glutathione, but elevated gamma-glutamylcysteine, the immediate precursor of glutathione.
Function-related keywords:
Literature:
- Coordinated activation of metabolic pathways for antioxidants and defence compounds by jasmonates and their roles in stress tolerance in Arabidopsis. DOI: 10.1111/j.1365-313X.2005.02560.x ; PMID: 16262714
- Systems analysis of seed filling in Arabidopsis: using general linear modeling to assess concordance of transcript and protein expression. DOI: 10.1104/pp.109.152413 ; PMID: 20118269
- Identification of nuclear genes encoding chloroplast-localized proteins required for embryo development in Arabidopsis. DOI: 10.1104/pp.110.168120 ; PMID: 21139083
- Feedback inhibition by thiols outranks glutathione depletion: a luciferase-based screen reveals glutathione-deficient γ-ECS and glutathione synthetase mutants impaired in cadmium-induced sulfate assimilation. DOI: 10.1111/j.1365-313X.2012.04924.x ; PMID: 22283708
- Correlation between hormonal homeostasis and morphogenic responses in Arabidopsis thaliana seedlings growing in a Cd/Cu/Zn multi-pollution context. DOI: 10.1111/ppl.12050 ; PMID: 23496095
- Zinc-Finger Transcription Factor ZAT6 Positively Regulates Cadmium Tolerance through the Glutathione-Dependent Pathway in Arabidopsis. DOI: 10.1104/pp.15.01882 ; PMID: 26983992
- A role for APX1 gene in lead tolerance in Arabidopsis thaliana. DOI: 10.1016/j.plantsci.2016.11.015 ; PMID: 28167043
- WRKY12 represses GSH1 expression to negatively regulate cadmium tolerance in Arabidopsis. DOI: 10.1007/s11103-018-0809-7 ; PMID: 30617455
- Endoplasmic reticulum stress regulates glutathione metabolism and activities of glutathione related enzymes in Arabidopsis. DOI: 10.1071/FP17151 ; PMID: 32291042
- The effect of light quality on plant physiology, photosynthetic, and stress response in Arabidopsis thaliana leaves. DOI: 10.1371/journal.pone.0247380 ; PMID: 33661984
- A MYB4-MAN3-Mannose-MNB1 signaling cascade regulates cadmium tolerance in Arabidopsis. DOI: 10.1371/journal.pgen.1009636 ; PMID: 34181654
- Unexpected protein families including cell defense components feature in the N-myristoylome of a higher eukaryote. DOI: 10.1074/jbc.M307321200 ; PMID: 12912986
- Coordinated activation of metabolic pathways for antioxidants and defence compounds by jasmonates and their roles in stress tolerance in Arabidopsis. DOI: 10.1111/j.1365-313X.2005.02560.x ; PMID: 16262714
- Analysis of protein complexes in Arabidopsis leaves using size exclusion chromatography and label-free protein correlation profiling. DOI: 10.1016/j.jprot.2017.06.004 ; PMID: 28627464
Sequences:
cDNA Sequence
- >AT5G27380.1
ATTTAACAAAACGAAAAAGAGAACAAATACTGTAGTAGCGATCTTTTTGATCCAAACAAAAAAAATCAAACCAAAAAATCGTAGCGATCTTTGTTTGACTGAGATGGGCAGTGGCTGCTCTTCTCTCTCTTACTCATCATCTTCCACTTGCAATGCCACTGTTTTCTCTATTTCTTCTTCTCCATCATCTTCTTCTTCGCTGAAACTCAATCCAAGTAGCTTCCTTTTCCAGAACCCTAAAACTCTGAGAAATCAGTCACCTTTGAGGTGTGGGAGATCATTTAAGATGGAATCACAGAAACCCATTTTCGATTTGGAGAAATTAGATGATGAGTTTGTTCAGAAACTGGTTTACGATGCTCTCGTTTGGTCTTCTCTTCACGGACTCGTCGTTGGTGACAAAAGTTATCAGAAATCAGGAAATGTTCCAGGGGTTGGATTGATGCACGCACCTATTGCATTGCTACCAACTGCATTCCCAGAAGCTTATTGGAAGCAAGCTTGTAATGTTACTCCTCTTTTCAATGAATTGATTGATCGTGTTAGCTTGGATGGCAAATTCTTACAGGATAGTCTCTCTAGAACGAAGAAAGTTGATGTCTTTACATCTAGACTTCTTGACATTCACTCCAAGATGCTAGAAAGAAATAAGAAAGAGGACATTCGTTTGGGTTTACACCGGTTTGATTATATGCTTGACGAAGAAACAAATTCACTTCTTCAGATTGAGATGAATACTATCTCGTGTTCGTTTCCTGGCCTTAGTCGTCTTGTTAGCCAGCTACATCAGTCATTGCTTCGATCTTATGGGGATCAGATTGGCATAGACTCTGAACGTGTACCTATAAACACATCCACAATCCAATTTGCTGATGCATTGGCTAAAGCTTGGTTGGAGTACAGTAACCCAAGAGCGGTAGTCATGGTAATTGTACAGCCAGAAGAACGCAACATGTACGATCAACATTTGCTGAGCAGTATATTGAGAGAAAAGCATAATATAGTTGTCATCAGGAAGACTCTAGCAGAAGTCGAAAAAGAAGGGAGTGTACAAGAGGATGAAACCCTTATTGTTGGCGGCCAAGCAGTCGCAGTGGTTTATTTCAGATCTGGCTATACTCCTAATGATCATCCGTCTGAATCAGAATGGAATGCTAGGCTGCTTATTGAGGAGTCTTCAGCTGTCAAATGCCCGAGCATAGCTTACCATTTAACTGGCTCCAAGAAAATCCAGCAAGAACTGGCTAAACCAGGTGTTCTCGAGAGGTTTCTGGACAACAAAGAGGACATTGCTAAGCTGAGGAAATGCTTTGCTGGGCTTTGGAGCTTGGATGACTCAGAAATTGTCAAGCAGGCTATCGAAAAACCCGGATTGTTTGTTATGAAGCCTCAGAGAGAAGGCGGAGGAAACAACATCTATGGAGATGATGTGAGGGAAAATCTTTTGAGACTGCAGAAAGAAGGAGAGGAAGGAAACGCTGCGTATATCCTGATGCAGAGGATATTCCCAAAAGTCTCAAACATGTTCTTGGTGCGAGAAGGCGTTTACCATAAGCATCAAGCTATATCAGAACTCGGTGTCTATGGTGCTTACCTCAGGAGCAAAGACGAAGTTATAGTAAACGAGCAGAGTGGTTATCTAATGCGCACGAAGATCGCATCATCAGATGAAGGCGGCGTTGCAGCTGGTTTTGGAGTCTTGGACAGCATATATCTGATTTGAGATGGATAACATTCACAACCATCTTGATCAGTTTTTCTTCTGGTTTATTCCTTCTTCTTCTCTTCTTGCTTGTTAAAGATTTGTGTATTAATCATGAAGATCAATAAGACTAGGCAAAGCTCTTTACAATTCTTTCCACAGGACCGCAAAGCCTACATTGCTTATTGTTATTTTTAGACCGTGTGAGATGATTACTCGTTTATAAAGATCATGAATTGAATAAGATAAGATCAATCATGGAATTTGGGGTATAAAGATTATTACCATAGCAACATATTTAGACCATAGGCACATATATG
CDS Sequence
Protein Sequence