Gene Details:

• Gene ID: AT5G27150
• Gene Symbol: AT-NHX1, ATNHX, ATNHX1, NHX1
• Gene Name: Na+/H+ exchanger 1
• Description: Na+/H+ exchanger 1;(source:Araport11)
• TAIR Accession:
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G27150.1

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)

Germplasm Phenotype:

• nhx1  — Reduced monovalent cation-dependent proton transport activity. Vacuoles isolated from leaves had a much lower Na+/H+ exchange activity. Altered leaf development, with a reduction in the frequency of large epidermal cells and a reduction in overally leaf area compared to wt plants.

Function-related keywords:

• root

Literature:

• The Arabidopsis thaliana proton transporters, AtNhx1 and Avp1, can function in cation detoxification in yeast.   DOI:  10.1073/pnas.96.4.1480 ;  PMID:  9990049
• Na+/H+ antiporter from Synechocystis species PCC 6803, homologous to SOS1, contains an aspartic residue and long C-terminal tail important for the carrier activity.   DOI:  10.1104/pp.125.1.437 ;  PMID:  11154351
• Halotolerant cyanobacterium Aphanothece halophytica contains an Na(+)/H(+) antiporter, homologous to eukaryotic ones, with novel ion specificity affected by C-terminal tail.   DOI:  10.1074/jbc.M103650200 ;  PMID:  11479290
• Phylogenetic relationships within cation transporter families of Arabidopsis.   DOI:  10.1104/pp.126.4.1646 ;  PMID:  11500563
• Differential expression and function of Arabidopsis thaliana NHX Na+/H+ antiporters in the salt stress response.   DOI:  10.1046/j.1365-313x.2002.01309.x ;  PMID:  12047628
• Regulation of expression of the vacuolar Na+/H+ antiporter gene AtNHX1 by salt stress and abscisic acid.   DOI:  10.1023/a:1019859319617 ;  PMID:  12369629
• Regulation of vacuolar Na+/H+ exchange in Arabidopsis thaliana by the salt-overly-sensitive (SOS) pathway.   DOI:  10.1074/jbc.M307982200 ;  PMID:  14570921
• DNA array analyses of Arabidopsis thaliana lacking a vacuolar Na+/H+ antiporter: impact of AtNHX1 on gene expression.   DOI:  10.1111/j.1365-313X.2004.02253.x ;  PMID:  15546358
• Cloning and characterization of a wheat vacuolar cation/proton antiporter and pyrophosphatase proton pump.   DOI:  10.1016/j.plaphy.2005.02.010 ;  PMID:  15907686
• Vacuolar Na+/H+ antiporter cation selectivity is regulated by calmodulin from and pH-dependent manner.   DOI:  10.1073/pnas.0504437102 ;  PMID:  16249341
• Alkali cation exchangers: roles in cellular homeostasis and stress tolerance.   DOI:  10.1093/jxb/erj114 ;  PMID:  16513813
• Arabidopsis-rice-wheat gene orthologues for Na+ transport and transcript analysis in wheat-L. elongatum aneuploids under salt stress.   DOI:  10.1007/s00438-006-0184-y ;  PMID:  17103227
• AtNHX8, a member of the monovalent cation: proton antiporter-1 family in Arabidopsis thaliana, encodes a putative Li/H antiporter.   DOI:  10.1111/j.1365-313X.2006.02990.x ;  PMID:  17270011
• Impact of AtNHX1, a vacuolar Na+/H+ antiporter, upon gene expression during and long-term salt stress in Arabidopsis thaliana.   DOI:  10.1186/1471-2229-7-18 ;  PMID:  17411438
• Enhanced salt tolerance of transgenic progeny of tall fescue (Festuca arundinacea) expressing a vacuolar Na+/H+ antiporter gene from Arabidopsis.   DOI:  10.1016/j.jplph.2007.04.001 ;  PMID:  17561307
• Salt tolerance conferred by overexpression of Arabidopsis vacuolar Na(+)/H (+) antiporter gene AtNHX1 in common buckwheat (Fagopyrum esculentum).   DOI:  10.1007/s11248-007-9085-z ;  PMID:  17541720
• Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.   DOI:  10.1104/pp.108.126375 ;  PMID:  18775970
• Overexpression of SOS (Salt Overly Sensitive) genes increases salt tolerance in transgenic Arabidopsis.   DOI:  10.1093/mp/ssn058 ;  PMID:  19529826
• HKT transporter-mediated salinity resistance mechanisms in Arabidopsis and monocot crop plants.   DOI:  10.1016/j.tplants.2009.08.009 ;  PMID:  19783197
• Comparative effect of potassium on K and Na uptake and transport in two accessions of Arabidopsis thaliana during salinity stress.   DOI:  10.1016/j.crvi.2009.05.003 ;  PMID:  19748453
• Regulation by salt of vacuolar H+-ATPase and H+-pyrophosphatase activities and Na+/H+ exchange.   DOI:  10.4161/psb.4.8.9236 ;  PMID:  19820346
• Overexpression of soybean ubiquitin-conjugating enzyme gene GmUBC2 confers enhanced drought and salt tolerance through modulating abiotic stress-responsive gene expression in Arabidopsis.   DOI:  10.1007/s11103-009-9575-x ;  PMID:  19941154
• Dynamic aspects of ion accumulation by vesicle traffic under salt stress in Arabidopsis.   DOI:  10.1093/pcp/pcp143 ;  PMID:  19880402
• Variation in salinity tolerance and shoot sodium accumulation in Arabidopsis ecotypes linked to differences in the natural expression levels of transporters involved in sodium transport.   DOI:  10.1111/j.1365-3040.2009.02105.x ;  PMID:  20040066
• A novel plant vacuolar Na+/H+ antiporter gene evolved by DNA shuffling confers improved salt tolerance in yeast.   DOI:  10.1074/jbc.M109.073783 ;  PMID:  20457597
• Comparative genomic analysis of 1047 completely sequenced cDNAs from an Arabidopsis-related model halophyte, Thellungiella halophila.   DOI:  10.1186/1471-2229-10-261 ;  PMID:  21106055
• Assessing the role of root plasma membrane and tonoplast Na+/H+ exchangers in salinity tolerance in wheat: in planta quantification methods.   DOI:  10.1111/j.1365-3040.2011.02296.x ;  PMID:  21342209
• The Arabidopsis Na+/H+ antiporters NHX1 and NHX2 control vacuolar pH and K+ homeostasis to regulate growth, flower development, and reproduction.   DOI:  10.1105/tpc.111.089581 ;  PMID:  21954467
• Arabidopsis NRT1.5 is another essential component in the regulation of nitrate reallocation and stress tolerance.   DOI:  10.1104/pp.112.199257 ;  PMID:  22685171
• A stress inducible SUMO conjugating enzyme gene (SaSce9) from a grass halophyte Spartina alterniflora enhances salinity and drought stress tolerance in Arabidopsis.   DOI:  10.1186/1471-2229-12-187 ;  PMID:  23051937
• Physiological and molecular mechanisms of plant salt tolerance.   DOI:  10.1007/s11120-013-9813-6 ;  PMID:  23539361
• A Medicago truncatula EF-hand family gene, MtCaMP1, is involved in drought and salt stress tolerance.   DOI:  10.1371/journal.pone.0058952 ;  PMID:  23593126
• SKIP Confers Osmotic Tolerance during Salt Stress by Controlling Alternative Gene Splicing in Arabidopsis.   DOI:  10.1016/j.molp.2015.01.011 ;  PMID:  25617718
• Chrysanthemum WRKY gene CmWRKY17 negatively regulates salt stress tolerance in transgenic chrysanthemum and Arabidopsis plants.   DOI:  10.1007/s00299-015-1793-x ;  PMID:  25893877
• Heterologous expression of the halophyte Zoysia matrella H⁺-pyrophosphatase gene improved salt tolerance in Arabidopsis thaliana.   DOI:  10.1016/j.plaphy.2015.04.004 ;  PMID:  25874657
• Potassium Retention under Salt Stress Is Associated with Natural Variation in Salinity Tolerance among Arabidopsis Accessions.   DOI:  10.1371/journal.pone.0124032 ;  PMID:  25993093
• Endogenous Arabidopsis messenger RNAs transported to distant tissues.   DOI:  10.1038/nplants.2015.25 ;  PMID:  27247031
• Co-overexpressing a Plasma Membrane and a Vacuolar Membrane Sodium/Proton Antiporter Significantly Improves Salt Tolerance in Transgenic Arabidopsis Plants.   DOI:  10.1093/pcp/pcw055 ;  PMID:  26985021
• Cold stress increases salt tolerance of the extremophytes Eutrema salsugineum (Thellungiella salsuginea) and Eutrema (Thellungiella) botschantzevii.   DOI:  10.1016/j.jplph.2016.10.009 ;  PMID:  27940414
• Beneficial Rhizobacterium Bacillus amyloliquefaciens SQR9 Induces Plant Salt Tolerance through Spermidine Production.   DOI:  10.1094/MPMI-02-17-0027-R ;  PMID:  28291380
• Salt stress-induced FERROCHELATASE 1 improves resistance to salt stress by limiting sodium accumulation in Arabidopsis thaliana.   DOI:  10.1038/s41598-017-13593-9 ;  PMID:  29116128
• Pseudomonas knackmussii MLR6, a rhizospheric strain isolated from halophyte, enhances salt tolerance in Arabidopsis thaliana.   DOI:  10.1111/jam.14082 ;  PMID:  30142236
• Full-length transcriptome sequences of ephemeral plant Arabidopsis pumila provides insight into gene expression dynamics during continuous salt stress.   DOI:  10.1186/s12864-018-5106-y ;  PMID:  30261913
• K(+) Efflux Antiporters 4, 5, and 6 Mediate pH and K(+) Homeostasis in Endomembrane Compartments.   DOI:  10.1104/pp.18.01053 ;  PMID:  30309966
• The Effect of AtHKT1;1 or AtSOS1 Mutation on the Expressions of Na⁺ or K⁺ Transporter Genes and Ion Homeostasis in Arabidopsis thaliana under Salt Stress.   DOI:  10.3390/ijms20051085 ;  PMID:  30832374
• CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 6: A Key Regulator of Na(+) Homeostasis during Germination.   DOI:  10.1104/pp.19.00119 ;  PMID:  30894419
• PLATZ2 negatively regulates salt tolerance in Arabidopsis seedlings by directly suppressing the expression of the CBL4/SOS3 and CBL10/SCaBP8 genes.   DOI:  10.1093/jxb/eraa259 ;  PMID:  32453821
• Auxin Homeostasis and Distribution of the Auxin Efflux Carrier PIN2 Require Vacuolar NHX-Type Cation/H(+) Antiporter Activity.   DOI:  10.3390/plants9101311 ;  PMID:  33023035
• Induction of Salt Tolerance in Arabidopsis thaliana by Volatiles From Bacillus amyloliquefaciens FZB42 via the Jasmonic Acid Signaling Pathway.   DOI:  10.3389/fmicb.2020.562934 ;  PMID:  33281760
• Identification and Functional Analysis of Two Purple Acid Phosphatases AtPAP17 and AtPAP26 Involved in Salt Tolerance in Arabidopsis thaliana Plant.   DOI:  10.3389/fpls.2020.618716 ;  PMID:  33679819
• The Endophytic Strain ZS-3 Enhances Salt Tolerance in Arabidopsis thaliana by Regulating Photosynthesis, Osmotic Stress, and Ion Homeostasis and Inducing Systemic Tolerance.   DOI:  10.3389/fpls.2022.820837 ;  PMID:  35386673
• Heterologous expression of a Fraxinus velutina SnRK2 gene in Arabidopsis increases salt tolerance by modifying root development and ion homeostasis.   DOI:  10.1007/s00299-022-02899-2 ;  PMID:  35794394
• Karrikin Receptor KAI2 Coordinates Salt Tolerance Mechanisms in Arabidopsis thaliana.   DOI:  10.1093/pcp/pcac121 ;  PMID:  35997763
• RAP2.6 enhanced salt stress tolerance by reducing Na(+) accumulation and stabilizing the electron transport in Arabidopsis thaliana.   DOI:  10.1016/j.plaphy.2023.01.003 ;  PMID:  36634508
• Phylogenetic relationships within cation transporter families of Arabidopsis.   DOI:  10.1104/pp.126.4.1646 ;  PMID:  11500563
• Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry.   DOI:  10.1074/mcp.T300006-MCP200 ;  PMID:  14506206

Sequences: