Gene Details:

• Gene ID: AT5G26030
• Gene Symbol: ATFC-I, FC-I, FC1, FC1
• Gene Name: ferrochelatase 1, FUS3-complementing gene 1
• Description: ferrochelatase 1;(source:Araport11)
• TAIR Accession: locus:2180642
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G26030.1     AT5G26030.2

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)

Gene Ontology:

• GO:0006783  — involved in — heme biosynthetic process
• GO:0004325  — enables — ferrochelatase activity
• GO:0006783  — acts upstream of or within — heme biosynthetic process
• GO:0006979  — acts upstream of or within — response to oxidative stress
• GO:0005739  — located in — mitochondrion
• GO:0033014  — acts upstream of or within — tetrapyrrole biosynthetic process
• GO:0009507  — located in — chloroplast
• GO:0009536  — located in — plastid
• GO:0005739  — is active in — mitochondrion

Germplasm Phenotype:

• atfc1  — no visible phenotype. decreased heme contents in roots

Function-related keywords:

• root

Literature:

• Two different genes encode ferrochelatase in Arabidopsis: mapping, expression and subcellular targeting of the precursor proteins.   DOI:  10.1046/j.1365-313x.1998.00235.x ;  PMID:  9753778
• Arabidopsis thaliana ferrochelatase-I and -II are not imported into Arabidopsis mitochondria.   DOI:  10.1016/s0014-5793(01)02925-8 ;  PMID:  11602264
• Expression analysis of the two ferrochelatase genes in Arabidopsis in different tissues and under stress conditions reveals their different roles in haem biosynthesis.   DOI:  10.1023/a:1019959224271 ;  PMID:  12374307
• Genome organization in Arabidopsis thaliana: a survey for genes involved in isoprenoid and chlorophyll metabolism.   DOI:  10.1023/a:1023005504702 ;  PMID:  12777052
• Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana.   DOI:  10.1074/jbc.M308435200 ;  PMID:  14576160
• Gene expression profiling of the tetrapyrrole metabolic pathway in Arabidopsis with a mini-array system.   DOI:  10.1104/pp.104.042408 ;  PMID:  15326282
• Transcript profiling in Arabidopsis reveals complex responses to global inhibition of DNA methylation and histone deacetylation.   DOI:  10.1074/jbc.M409053200 ;  PMID:  15516340
• Mapping the Arabidopsis organelle proteome.   DOI:  10.1073/pnas.0506958103 ;  PMID:  16618929
• Synteny conservation between the Prunus genome and both the present and ancestral Arabidopsis genomes.   DOI:  10.1186/1471-2164-7-81 ;  PMID:  16615871
• Induction of isoforms of tetrapyrrole biosynthetic enzymes, AtHEMA2 and AtFC1, under stress conditions and their physiological functions in Arabidopsis.   DOI:  10.1104/pp.107.100065 ;  PMID:  17416636
• Integration of Arabidopsis thaliana stress-related transcript profiles, promoter structures, and cell-specific expression.   DOI:  10.1186/gb-2007-8-4-r49 ;  PMID:  17408486
• UV-B signaling pathways with different fluence-rate response profiles are distinguished in mature Arabidopsis leaf tissue by requirement for UVR8, HY5, and HYH.   DOI:  10.1104/pp.107.108456 ;  PMID:  18055587
• PIF1 directly and indirectly regulates chlorophyll biosynthesis to optimize the greening process in Arabidopsis.   DOI:  10.1073/pnas.0803611105 ;  PMID:  18591656
• Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis.   DOI:  10.1104/pp.108.126375 ;  PMID:  18775970
• Light signalling pathways regulating the Mg-chelatase branchpoint of chlorophyll synthesis during de-etiolation in Arabidopsis thaliana.   DOI:  10.1039/b802596g ;  PMID:  18846290
• Heme synthesis by plastid ferrochelatase I regulates nuclear gene expression in plants.   DOI:  10.1016/j.cub.2011.04.004 ;  PMID:  21565502
• Functional characterization of the two ferrochelatases in Arabidopsis thaliana.   DOI:  10.1111/pce.12248 ;  PMID:  24329537
• Endogenous Arabidopsis messenger RNAs transported to distant tissues.   DOI:  10.1038/nplants.2015.25 ;  PMID:  27247031
• Ubiquitin facilitates a quality-control pathway that removes damaged chloroplasts.   DOI:  10.1126/science.aac7444 ;  PMID:  26494759
• Allocation of Heme Is Differentially Regulated by Ferrochelatase Isoforms in Arabidopsis Cells.   DOI:  10.3389/fpls.2016.01326 ;  PMID:  27630653
• Transcriptional Regulation of Tetrapyrrole Biosynthesis in Arabidopsis thaliana.   DOI:  10.3389/fpls.2016.01811 ;  PMID:  27990150
• Salt stress-induced FERROCHELATASE 1 improves resistance to salt stress by limiting sodium accumulation in Arabidopsis thaliana.   DOI:  10.1038/s41598-017-13593-9 ;  PMID:  29116128
• Complementation studies of the Arabidopsis fc1 mutant substantiate essential functions of ferrochelatase 1 during embryogenesis and salt stress.   DOI:  10.1111/pce.13448 ;  PMID:  30242849
• Genome-wide identification of EMBRYO-DEFECTIVE (EMB) genes required for growth and development in Arabidopsis.   DOI:  10.1111/nph.16071 ;  PMID:  31334862
• The retrograde signaling protein GUN1 regulates tetrapyrrole biosynthesis.   DOI:  10.1073/pnas.1911251116 ;  PMID:  31732672
• Arabidopsis thaliana ferrochelatase-I and -II are not imported into Arabidopsis mitochondria.   DOI:  10.1016/s0014-5793(01)02925-8 ;  PMID:  11602264
• Mapping the Arabidopsis organelle proteome.   DOI:  10.1073/pnas.0506958103 ;  PMID:  16618929
• Induction of isoforms of tetrapyrrole biosynthetic enzymes, AtHEMA2 and AtFC1, under stress conditions and their physiological functions in Arabidopsis.   DOI:  10.1104/pp.107.100065 ;  PMID:  17416636

Sequences: